anti-Human TNFRSF1B antibody for Immunoassay

Recommended TNFRSF1B Antibody (supplied by: Log in to see )

Antigen
Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) Antibodies
  • MGC83471
  • LOC100218184
  • TRAF2
  • TANK
  • TNF-RII/TNFRSF1B
  • TNFRSF1B
  • CD120b
  • TBPII
  • TNF-R-II
  • TNF-R75
  • TNFBR
  • TNFR1B
  • TNFR2
  • TNFR80
  • p75
  • p75TNFR
  • TNF-R2
  • TNF-alphaR2
  • TNFRII
  • TNFalpha-R2
  • Tnfr-1
  • Tnfr2
  • TNFR-II
  • TNF receptor-associated factor 2
  • TNF receptor-associated factor 6, E3 ubiquitin protein ligase
  • TNF receptor-associated factor 3
  • TRAF family member-associated NFKB activator
  • tumor necrosis factor receptor superfamily, member 1B
  • tumor necrosis factor receptor superfamily, member 1b
  • TRAF2
  • traf2
  • TRAF6
  • LOC100218184
  • LOC100359083
  • TANK
  • TNFRSF1B
  • LOC100222629
  • Tnfrsf1b
Reactivity
Human
189
135
52
6
3
2
2
2
2
2
2
Host
Mouse
128
90
24
20
16
13
1
Clonality
Monoclonal
Conjugate
This TNFRSF1B antibody is conjugated to FITC
29
13
10
6
6
6
5
4
4
4
4
3
3
2
2
2
2
2
2
2
2
2
2
1
1
1
Application
Functional Studies (Func), Immunoassay (IA), Flow Cytometry (FACS)
164
112
95
57
56
43
28
26
19
19
8
8
7
7
6
3
3
2
1
1
1
1
Options
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Catalog No. ABIN2191888
$ 667.76
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN2191889 Func IA FACS Biotin Mouse IgG1 Log in to see 80M2 3
1 ABIN2191871 CC IA IHC (fro) FACS WB Biotin Mouse Log in to see MR2-1 2
1 ABIN2191887 Func IA FACS Mouse IgG1 Log in to see 80M2 3
1 ABIN2192216 Func IA FACS IP WB FITC Mouse Log in to see MR2-1 1

General

Antigen Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) Antibodies
Reactivity Human
(189), (135), (52), (6), (3), (2), (2), (2), (2), (2), (2)
Host Mouse
(128), (90), (24), (20), (16), (13), (1)
Clonality (Clone)
Monoclonal   ( )
Conjugate This TNFRSF1B antibody is conjugated to FITC
(29), (13), (10), (6), (6), (6), (5), (4), (4), (4), (4), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application Functional Studies (Func), Immunoassay (IA), Flow Cytometry (FACS)
(164), (112), (95), (57), (56), (43), (28), (26), (19), (19), (8), (8), (7), (7), (6), (3), (3), (2), (1), (1), (1), (1)
Pubmed 3 references available
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Product Details anti-TNFRSF1B Antibody

Target Details TNFRSF1B Application Details Handling ProductDetails: References for anti-TNFRSF1B antibody (ABIN2191888) Images
Cross-Reactivity (Details) Cross reactivity: Rat : Yes
Sterility 0.2 μm filtered
Clone 80M2
Isotype IgG1

Target Details TNFRSF1B

Product Details anti-TNFRSF1B Antibody Application Details Handling ProductDetails: References for anti-TNFRSF1B antibody (ABIN2191888) Images back to top
Antigen
Alternative Name Tnf-Rii (TNFRSF1B Antibody Abstract)
Background The monoclonal antibody 80M2 recognizes the extracellular part of membrane-bound TNF-RII as well as the soluble form of TNF-RII which is generated by proteolytic cleavage of the extracellular domain. The soluble form can still bind TNF-alpha with high affinity and functions as a TNF-alpha antagonist. TNF-alpha is an important signaling protein in the immune system which can activate inflammatory responses, induce apoptosis, regulate cellular proliferation, and may even promote cancer progression. TNF-alpha can bind to two structurally distinct membrane receptors, TNF-RI and TNF- RII, which have both distinct and overlapping downstream signaling cascades. TNFRI is believed to be expressed on nearly all cell types, whereas TNFRII exhibits more restricted expression, being found on certain subpopulations of immune cells and several other cell types. A dominant role of TNF- RII has been shown in thymocyte activation by TNF-alpha, whereas induction of cytotoxicity and other functions are mediated largely by TNF-RI. TNF-RI is equally well activated by both the 17 kDa soluble and 26 kDa membrane-bound form, whereas TNF-RII is activated only by the membrane bound form of TNF-alpha. The antibody is a non-agonistic receptor modulating antibody. It enhances in vitro TNF alpha responses by increasing the affinity of the soluble form of TNF-alpha for TNF-RII. Aliases Tumor necrosis factor receptor superfamily member 1B, CD120b, TNF-R2, p75, p80 TNF-alpha receptor
Pathways NF-kappaB Signaling, Apoptosis, Cellular Response to Molecule of Bacterial Origin, Hepatitis C

Application Details

Product Details anti-TNFRSF1B Antibody Target Details TNFRSF1B Handling ProductDetails: References for anti-TNFRSF1B antibody (ABIN2191888) Images back to top
Application Notes For immunofluorescence and flow cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, dilutions have to be optimized in user's experimental setting. 1
Restrictions For Research Use only

Handling

Product Details anti-TNFRSF1B Antibody Target Details TNFRSF1B Application Details ProductDetails: References for anti-TNFRSF1B antibody (ABIN2191888) Images back to top
Buffer PBS, containing 1 % bovine serum. 2 1,2,4,5 2 3
Storage 4 °C
Storage Comment Product should be stored at 4 °C. Under recommended storage conditions, product is stable for at least one year. The exact expiry date is indicated on the label.

ProductDetails: References for anti-TNFRSF1B antibody (ABIN2191888)

Product Details anti-TNFRSF1B Antibody Target Details TNFRSF1B Application Details Handling Images back to top
Background publications

Till, Rosenstiel, Krippner-Heidenreich, Mascheretti-Croucher, Croucher, Schäfer, Scheurich, Seegert, Schreiber: "The Met-196 -> Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-alpha-induced apoptosis by impaired NF-kappaB signaling and target gene expression." in: The Journal of biological chemistry, Vol. 280, Issue 7, pp. 5994-6004, 2005

Grell, Douni, Wajant, Löhden, Clauss, Maxeiner, Georgopoulos, Lesslauer, Kollias, Pfizenmaier, Scheurich: "The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor." in: Cell, Vol. 83, Issue 5, pp. 793-802, 1996

Product cited in:

Scherübl, Schneider-Brachert, Schütze, Hehlgans, Männel: "Colocalization of endogenous TNF with a functional intracellular splice form of human TNF receptor type 2." in: Journal of inflammation (London, England), Vol. 2, pp. 7, 2005