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|Application / Reactivity||Rat (Rattus)||Human|
|ELISA||8 Antibodies||55 Antibodies|
|Enzyme Immunoassay (EIA)||4 Antibodies||13 Antibodies|
|Flow Cytometry (FACS)||2 Antibodies||39 Antibodies|
|Functional Studies (Func)||3 Antibodies||18 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||5 Antibodies|
|Immunofluorescence (IF)||10 Antibodies|
|Immunohistochemistry (IHC)||6 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||1 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||8 Antibodies|
|Immunoprecipitation (IP)||9 Antibodies|
|Western Blotting (WB)||26 Antibodies|
|Agonist (Agon)||1 Antibodies|
|Blocking Antibody (Inhibition)||2 Antibodies|
|Cell Culture (CC)||2 Antibodies|
|Antigen||Tumor Necrosis Factor Receptor Superfamily, Member 1B (TNFRSF1B) Antibodies|
|Reactivity||Human, Rat (Rattus) Alternatives|
|Conjugate||This TNFRSF1B antibody is conjugated to FITC Alternatives|
Functional Studies (Func), Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunoprecipitation (IP)
|5 references available|
|Supplier||Log in to see|
Product Details anti-TNFRSF1B AntibodyTarget Details TNFRSF1B Application Details Handling References for anti-TNFRSF1B Antibody (ABIN1105817) Images
|Cross-Reactivity (Details)||Species reactivity (tested):Human|
Target Details TNFRSF1BProduct Details anti-TNFRSF1B Antibody Application Details Handling References for anti-TNFRSF1B Antibody (ABIN1105817) Images back to top
|Alternative Name||CD120b / TNFR2 (TNFRSF1B Antibody Abstract)|
|Background||TNF-alpha is an important signaling protein in the immune system which can activate inflammatory responses, induce apoptosis, regulate cellular proliferation, and may even promote cancer progression. TNF-alpha can bind to two structurally distinct membrane receptors, TNF-RI and TNF-RII, which have both distinct and overlapping downstream signaling cascades. TNFRI is believed to be expressed on nearly all cell types, whereas TNFRII exhibits more restricted expression, being found on certain subpopulations of immune cells and several other cell types. A dominant role of TNF-RII has been shown in thymocyte activation by TNF-alpha, whereas induction of cytotoxicity and other functions are mediated largely by TNF-RI. TNF-RI is equally well activated by both the 17 kDa soluble and 26 kDa membrane-bound form, whereas TNF-RII is activated only by the membrane bound form of TNF-alpha.Synonyms: TNF-R2, TNFBR, TNFRSF1B, Tumor necrosis factor receptor 2, Tumor necrosis factor receptor superfamily member 1B, Tumor necrosis factor receptor type II, p80 TNF-alpha receptor|
|Research Area||CD Antigens, Surface Receptors of Immune Cells|
|Pathways||NF-kappaB Signaling, Apoptosis|
Application DetailsProduct Details anti-TNFRSF1B Antibody Target Details TNFRSF1B Handling References for anti-TNFRSF1B Antibody (ABIN1105817) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFRSF1B Antibody Target Details TNFRSF1B Application Details References for anti-TNFRSF1B Antibody (ABIN1105817) Images back to top
|Buffer||PBS, 1 % bovine serum|
|Storage Comment||Store at 2 - 8 °C.|
References for anti-TNFRSF1B Antibody (ABIN1105817)Product Details anti-TNFRSF1B Antibody Target Details TNFRSF1B Application Details Handling Images back to top
|Product cited in:||
Krippner-Heidenreich, Grunwald, Zimmermann et al.: "Single-chain TNF, a TNF derivative with enhanced stability and antitumoral activity." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 180, Issue 12, pp. 8176-83, 2008 (PubMed).
Leccardi, Decarli, Lorenzelli et al.: "Long-term outdoor reliability assessment of a wireless unit for air-quality monitoring based on nanostructured films integrated on micromachined platforms." in: Sensors (Basel, Switzerland), Vol. 12, Issue 6, pp. 8176-92, 2012 (PubMed).
Fairfax, Davenport, Makino et al.: "A common haplotype of the TNF receptor 2 gene modulates endotoxin tolerance." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 5, pp. 3058-65, 2011 (PubMed).
Till, Rosenstiel, Krippner-Heidenreich et al.: "The Met-196 -> Arg variation of human tumor necrosis factor receptor 2 (TNFR2) affects TNF-alpha-induced apoptosis by impaired NF-kappaB signaling and target gene expression." in: The Journal of biological chemistry, Vol. 280, Issue 7, pp. 5994-6004, 2005 (PubMed).
Grell, Douni, Wajant et al.: "The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor." in: Cell, Vol. 83, Issue 5, pp. 793-802, 1996 (PubMed).