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|Application / Reactivity||Human|
|Blocking Antibody (Inhibition)||4 Antibodies|
|ELISA (Detection)||1 Antibodies|
|Enzyme Immunoassay (EIA)||10 Antibodies|
|Flow Cytometry (FACS)||18 Antibodies|
|Functional Studies (Func)||3 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||9 Antibodies|
|Immunofluorescence (IF)||21 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||22 Antibodies|
|Immunohistochemistry (IHC)||28 Antibodies|
|Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))||1 Antibodies|
|Immunohistochemistry (Formalin-fixed Sections) (IHC (f))||1 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||2 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||23 Antibodies|
|Immunoprecipitation (IP)||2 Antibodies|
|Neutralization (Neut)||1 Antibodies|
|Antigen||Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) Antibodies|
|Conjugate||This TNFSF11 antibody is conjugated to Biotin Alternatives|
Flow Cytometry (FACS)
|5 references available|
|Supplier||Log in to see|
Product Details anti-TNFSF11 AntibodyTarget Details TNFSF11 Application Details Handling References for anti-TNFSF11 Antibody (ABIN2660831) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with biotin under optimal conditions. The solution is free of unconjugated biotin.|
Target Details TNFSF11Product Details anti-TNFSF11 Antibody Application Details Handling References for anti-TNFSF11 Antibody (ABIN2660831) Images back to top
|Alternative Name||CD254 (TNFSF11 Antibody Abstract)|
|Background||Human CD254, also known as RANKL, TRANCE, and OPGL, is a type II transmembrane protein in the TNF superfamily that has two forms: a membrane-anchored protein and a secreted protein. Its extracellular domain is related to TRAIL, FasL, and TNF. CD254 is expressed on osteoclasts and activated T cells. It has been implicated in the regulation of the interactions between T cells and dendritic cells. It plays an important role in osteoclast differentiation and bone resorption. CD254 activates JNK and NF-κB and induces the expression of IL-1, IL-6, IL-12, and IL-15 in dendritic cells.|
Application DetailsProduct Details anti-TNFSF11 Antibody Target Details TNFSF11 Handling References for anti-TNFSF11 Antibody (ABIN2660831) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFSF11 Antibody Target Details TNFSF11 Application Details References for anti-TNFSF11 Antibody (ABIN2660831) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-TNFSF11 Antibody (ABIN2660831)Product Details anti-TNFSF11 Antibody Target Details TNFSF11 Application Details Handling Images back to top
Mueller, Brieske, Schinke et al.: "Plasma cells within granulomatous inflammation display signs pointing to autoreactivity and destruction in granulomatosis with polyangiitis." in: Arthritis research & therapy, Vol. 16, Issue 1, pp. R55, 2014 (PubMed).
Ji, Park-Min, Shen et al.: "Inhibition of RANK expression and osteoclastogenesis by TLRs and IFN-gamma in human osteoclast precursors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 11, pp. 7223-33, 2009 (PubMed).
Page, Miossec: "RANK and RANKL expression as markers of dendritic cell-T cell interactions in paired samples of rheumatoid synovium and lymph nodes." in: Arthritis and rheumatism, Vol. 52, Issue 8, pp. 2307-12, 2005 (PubMed).
Kanamaru, Iwai, Ikeda et al.: "Expression of membrane-bound and soluble receptor activator of NF-kappaB ligand (RANKL) in human T cells." in: Immunology letters, Vol. 94, Issue 3, pp. 239-46, 2004 (PubMed).
Wiethe, Dittmar, Doan et al.: "Enhanced effector and memory CTL responses generated by incorporation of receptor activator of NF-kappa B (RANK)/RANK ligand costimulatory molecules into dendritic cell immunogens expressing a human ..." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 8, pp. 4121-30, 2003 (PubMed).
ImagesProduct Details anti-TNFSF11 Antibody Target Details TNFSF11 Application Details Handling References for anti-TNFSF11 Antibody (ABIN2660831) back to top