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|Application / Reactivity||Mouse (Murine)|
|Blocking Antibody (Inhibition)||1 Antibodies|
|Enzyme Immunoassay (EIA)||2 Antibodies|
|Flow Cytometry (FACS)||28 Antibodies|
|Functional Studies (Func)||2 Antibodies|
|Immunocytochemistry (ICC)||5 Antibodies|
|Immunofluorescence (IF)||12 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||22 Antibodies|
|Immunohistochemistry (IHC)||22 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||5 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||12 Antibodies|
|Immunoprecipitation (IP)||9 Antibodies|
|Neutralization (Neut)||2 Antibodies|
|Western Blotting (WB)||71 Antibodies|
|Antigen||Tumor Necrosis Factor (Ligand) Superfamily, Member 11 (TNFSF11) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This TNFSF11 antibody is conjugated to PE Alternatives|
Flow Cytometry (FACS)
|9 references available|
|Supplier||Log in to see|
Product Details anti-TNFSF11 AntibodyTarget Details TNFSF11 Application Details Handling References for anti-TNFSF11 Antibody (ABIN2663224) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with PE under optimal conditions. The solution is free of unconjugated PE and unconjugated antibody.|
Target Details TNFSF11Product Details anti-TNFSF11 Antibody Application Details Handling References for anti-TNFSF11 Antibody (ABIN2663224) Images back to top
|Alternative Name||CD254 (TNFSF11 Antibody Abstract)|
|Background||CD254 is a 19 kD TNF superfamily member also known as TRANCE (TNF-related activation induced cytokine), RANK ligand, RANKL, TNFSF11, OPGL, and ODF. TRANCE is expressed on activated T cells and osteoclasts and has been implicated in the regulation of T cell and dendritic cell interactions as well as osteoclast differentiation.|
Application DetailsProduct Details anti-TNFSF11 Antibody Target Details TNFSF11 Handling References for anti-TNFSF11 Antibody (ABIN2663224) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-TNFSF11 Antibody Target Details TNFSF11 Application Details References for anti-TNFSF11 Antibody (ABIN2663224) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-TNFSF11 Antibody (ABIN2663224)Product Details anti-TNFSF11 Antibody Target Details TNFSF11 Application Details Handling Images back to top
Takeshita, Fumoto, Naoe et al.: "Age-related marrow adipogenesis is linked to increased expression of RANKL." in: The Journal of biological chemistry, Vol. 289, Issue 24, pp. 16699-710, 2014 (PubMed).
Haslam, Drolet, Smith et al.: "Progestin-regulated luminal cell and myoepithelial cell-specific responses in mammary organoid culture." in: Endocrinology, Vol. 149, Issue 5, pp. 2098-107, 2008 (PubMed).
Fionda, Nappi, Piccoli et al.: "15-deoxy-Delta12,14-prostaglandin J2 negatively regulates rankl gene expression in activated T lymphocytes: role of NF-kappaB and early growth response transcription factors." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 178, Issue 7, pp. 4039-50, 2007 (PubMed).
Gao, Grassi, Ryan et al.: "IFN-gamma stimulates osteoclast formation and bone loss in vivo via antigen-driven T cell activation." in: The Journal of clinical investigation, Vol. 117, Issue 1, pp. 122-32, 2007 (PubMed).
Kamijo, Nakajima, Ikeda et al.: "Amelioration of bone loss in collagen-induced arthritis by neutralizing anti-RANKL monoclonal antibody." in: Biochemical and biophysical research communications, Vol. 347, Issue 1, pp. 124-32, 2006 (PubMed).
Miyahira, Akiba, Katae et al.: "Cutting edge: a potent adjuvant effect of ligand to receptor activator of NF-kappa B gene for inducing antigen-specific CD8+ T cell response by DNA and viral vector vaccination." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 171, Issue 12, pp. 6344-8, 2003 (PubMed).
Takayanagi, Ogasawara, Hida et al.: "T-cell-mediated regulation of osteoclastogenesis by signalling cross-talk between RANKL and IFN-gamma." in: Nature, Vol. 408, Issue 6812, pp. 600-5, 2000 (PubMed).
Wong, Besser, Kim et al.: "TRANCE, a TNF family member, activates Akt/PKB through a signaling complex involving TRAF6 and c-Src." in: Molecular cell, Vol. 4, Issue 6, pp. 1041-9, 2000 (PubMed).
Josien, Wong, Li et al.: "TRANCE, a TNF family member, is differentially expressed on T cell subsets and induces cytokine production in dendritic cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 162, Issue 5, pp. 2562-8, 1999 (PubMed).
ImagesProduct Details anti-TNFSF11 Antibody Target Details TNFSF11 Application Details Handling References for anti-TNFSF11 Antibody (ABIN2663224) back to top