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|Antigen||Programmed Cell Death 6 Interacting Protein (PDCD6IP) Antibodies|
|Reactivity||Human, Mouse (Murine), Rat (Rattus) Alternatives|
|Conjugate||This PDCD6IP antibody is conjugated to Alexa Fluor 488 Alternatives|
Immunofluorescence (Paraffin-embedded Sections) (IF (p))
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Product Details anti-PDCD6IP AntibodyTarget Details PDCD6IP Application Details Handling Images
|Purification||Purified by Protein A.|
|Immunogen||KLH conjugated synthetic peptide derived from human AIP1|
Target Details PDCD6IPProduct Details anti-PDCD6IP Antibody Application Details Handling Images back to top
|Alternative Name||AIP1 (PDCD6IP Antibody Abstract)|
AIP1 (ASK-interacting protein 1), also known as DAB2IP (DAB2 interacting protein), is a 1,189 amino acid protein that localizes to both the membrane and the cytoplasm and contains one Ras-GAP domain, one PH domain and one C2 domain. Expressed at low levels in prostate tissue, AIP1 functions as a Ras GTPase-activating protein that interacts with ASK 1 and, via this interaction, disrupts the association of ASK 1 with an inhibitory 14-3-3 complex, thereby allowing free ASK 1 to function within the cell. AIP1 exists as multiple alternatively spliced isoforms and is down-regulated in prostate cancer tissue, suggesting a role in tumor suppression. Chromosomal aberrations in the gene encoding AIP1 are associated with acute myeloid leukemia (AML), implicating a role for AIP1 fusion proteins in tumorigenesis.
Synonyms: Activin receptor interacting protein 1, Acvri1, Acvrinp1, ACVRIP1, AIP 1, Aip-1, ARIP1, Atrophin 1 interacting protein 1, Atrophin 1 interacting protein A, Atrophin-1-interacting protein 1, Atrophin-1-interacting protein A, MAGI-2, MAGI2, MAGI2_HUMAN, Membrane associated guanylate kinase 2, Membrane associated guanylate kinase inverted 2, Membrane associated guanylate kinase WW and PDZ domain containing 2, Membrane associated guanylate kinase WW and PDZ domain containing protein 2, Membrane-associated guanylate kinase, Membrane-associated guanylate kinase inverted 2, S SCAM, SSCAM, WW and PDZ domain-containing protein 2.
|Pathways||p53 Signaling, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation|
Application DetailsProduct Details anti-PDCD6IP Antibody Target Details PDCD6IP Handling Images back to top
|Application Notes||IF(IHC-P) 1:50-200|
|Restrictions||For Research Use only|
HandlingProduct Details anti-PDCD6IP Antibody Target Details PDCD6IP Application Details Images back to top
|Buffer||Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.|
|Storage Comment||Store at 4°C|
|Expiry Date||12 months|