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PCSK2 gene polymorphisms are associated with pleiotropic effects on various traits of glucose homeostasis and incident diabetes.
FAM20C (show FAM20C ELISA Kits) plays a role in 7B2 (show SCG5 ELISA Kits)-mediated proPC2 activation by phosphorylating residue Thr111; and that 7B2 (show SCG5 ELISA Kits) function is regulated by alternative splicing.
in the processing of hypothalamic neuropeptides in huntington disease (show HTT ELISA Kits) may partially arise from decreased PC1/3 (show PCSK1 ELISA Kits) and PC2 (show KRT6B ELISA Kits) expressions.
variant of the PCSK2 gene was associated with reduced glucose-stimulated insulin (show INS ELISA Kits) secretion, but also with lower glucagon (show GCG ELISA Kits) levels, which could potentially counteract the effects of decreased insulin (show INS ELISA Kits) secretion on the risk of type 2 diabetes
The association of risk allele rs2021785 at PCSK2 with type 2 diabetes exists in a Han Chinese population
differential gene expression profiles revealed more abundant mRNA expression in ectopic ACTH (show POMC ELISA Kits) syndrome than in Cushing disease of proprotein convertase-2
PC1/3 (show PCSK1 ELISA Kits) governs the endocrine, and PC2 (show KRT6B ELISA Kits) the neuronal processing, of proCCK, whereas PC5 (show PCSK5 ELISA Kits)/6 contributes only to a modest endocrine synthesis of CCK-22 (show CCK ELISA Kits).
SEMA3F (show SEMA3F ELISA Kits), CLEC16A (show CLEC16A ELISA Kits), LAMA3 (show LAMA3 ELISA Kits), and PCSK2 variants have roles in myocardial infarction in Japanese individuals
The presence of PC and GOAT in the cells, as well as n-octanoic acid in the culture medium, was necessary to produce n-octanoyl ghrelin (show GHRL ELISA Kits).
prominently expressed in PTHrP (show PTHLH ELISA Kits)-expressing human cancer cell lines originating from tumors of the breast, lung, prostate, as well as lymphoma
Study reports that PC2 null mice had increased number of mu opioid receptors in different brain areas. These mice also exhibited enhanced morphine-induced antinociception but reduced tolerance to and dependence on morphine.
PC1 (show PCSK1 ELISA Kits) and PC2 are involved in the C-terminal processing of protachykinin peptides and suggest a major role in the maturation of the protachykinin-1 (show TAC1 ELISA Kits) protein
activation of the hypothalamic GPR40 (show FFAR1 ELISA Kits)/FFA1 signaling pathway may regulate beta-endorphin (show POMC ELISA Kits) release via PC2, and regulate the endogenous pain control system
Pkd2 (show PKD2 ELISA Kits)(-/-) mice with homozygous PKD2 (show PKD2 ELISA Kits)(tg)-transgene alleles (Pkd2 (show PKD2 ELISA Kits)(-/-);PKD2 (show PKD2 ELISA Kits)(tg/tg (show CACNA1A ELISA Kits))) showed significant further amelioration of the cystic severity compared to that in Pkd2 (show PKD2 ELISA Kits)(-/-) mice
Pkd1 (show PKD1 ELISA Kits) and Pkd2 (show PKD2 ELISA Kits) have coordinate effects on osteoblast differentiation and opposite effects on adipogenesis, suggesting that Pkd1 (show PKD1 ELISA Kits) and Pkd2 (show PKD2 ELISA Kits) signaling pathways can have independent effects on mesenchymal lineage commitment in bone
novel protein complex composed of Rabep1 (show RABEP1 ELISA Kits), GGA1 (show GGA1 ELISA Kits) and Arl3 is responsible for the sorting and targeting of the polycystin 1 (show PKD1 ELISA Kits) andpolycystin 2 to the cilium.
Verified the roles of proprotein convertase subtilisin/kexin type 2 in regulating IGF1 (show IGF1 ELISA Kits) and female sexual maturation, it also might be involved in the regulation of aging.
PKD2 (show PKD2 ELISA Kits) regulates directly and indirectly about 5% of the cytotoxic T-cell phosphoproteome.
The results of this study demonstrate that PC1 (show PCSK1 ELISA Kits) trafficking and expression require GPS (show NBEAL2 ELISA Kits) cleavage and PC2 interaction, respectively, and provide a framework for functional assays to categorize the effects of missense mutations in polycystins.
In inner medullary collecting duct, flow, via polycystin-2 (show PKD2 ELISA Kits) and P2 receptors, engages Ca(2 (show CA2 ELISA Kits)+)-dependent signaling pathways that stimulate ET-1 (show EDN1 ELISA Kits) synthesis.
Prohormone convertase PC2 expression is up-regulated in a cell-specific manner in bovine neuroendocrine ocular ciliary epithelium.
Pcsk2 has been sequenced and characterized.
This gene encodes a member of the subtilisin-like proprotein convertase family. These enzymes process latent precursor proteins into their biologically active products. The encoded protein plays a critical role in hormone biosynthesis by processing a variety of prohormones including proinsulin, proopiomelanocortin and proluteinizing-hormone-releasing hormone. Single nucleotide polymorphisms in this gene may increase susceptibility to myocardial infarction and type 2 diabetes. This gene may also play a role in tumor development and progression. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
KEX2-like endoprotease 2
, neuroendocrine convertase 2
, prohormone convertase 2
, polycystic kidney disease 2 protein homolog
, polycystin 2
, NEC 2
, proprotein convertase 2
, proprotein convertase subtilisin/kexin type 2
, proprotein convertase type 2
, convertase PC2
, proprotein convertase subtilisin/kexin type 2 L homeolog
, prohormone convertase2