Leptin (LEP) (AA 29-164), (partial) protein (GST tag)

Details for Product No. ABIN1047336
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Protein Name
Synonyms ob, obese, LEPD, OB, OBS
Protein Characteristics
AA 29-164, partial
Origin
Human
(139), (44), (43), (23), (14), (13), (12), (10), (9), (9), (7), (7), (4), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Source
Escherichia coli (E. coli)
(223), (20), (3), (2), (2), (2), (1)
Protein Type Recombinant
Purification tag / Conjugate
This Leptin protein is labelled with GST tag.
Application
ELISA
Pubmed 4 references available
Quantity 50 μg
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Sequence DDTKTLIKTI VTRINDISHT QSVSSKQKVT GLDFIPGLHP ILTLSKMDQT LAVYQQILTS MPSRNVIQIS NDLENLRDLL HVLAFSKSCH LPWASGLETL DSLGGVLEAS GYSTEVVALS RLQGSLQDML WQLDLS
Characteristics Please inquire if you are interested in this recombinant protein expressed in E. coli, mammalien cells or by baculovirus infection. Be aware about differences in price and lead time.
Purity 90 %
Alternative Name Leptin protein
Background May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
Molecular Weight 42.4 kD
UniProt P41159
Comment

The yeast protein expression system is the most economical and efficient eukaryotic system for secretion and intracellular expression. A protein expressed by the mammalian cell system is of very high-quality and close to the natural protein. But the low expression level, the high cost of medium and the culture conditions restrict the promotion of mammalian cell expression systems. The yeast protein expression system serve as a eukaryotic system integrate the advantages of the mammalian cell expression system. A protein expressed by yeast system could be modificated such as glycosylation, acylation, phosphorylation and so on to ensure the native protein conformation. It can be used to produce protein material with high added value that is very close to the natural protein. Our proteins produced by yeast expression system has been used as raw materials for downstream preparation of monoclonal antibodies.

Restrictions For Research Use only
Format Lyophilized
Concentration 0.2-2 mg/mL
Buffer Tris-based buffer, 50 % glycerol
Handling Advice Repeated freezing and thawing is not recommended. Store working aliquots at 4 °C for up to one week
Storage -20 °C
Storage Comment Store at -20 °C for extended storage, conserve at -20 °C or -80 °C
Supplier Images
Leptin (LEP) (AA 29-164), (partial) protein (GST tag) Leptin (LEP) (AA 29-164), (partial) protein (GST tag)
Background publications Schubring, Prohaska, Prohaska et al.: "Leptin concentrations in maternal serum and amniotic fluid during the second trimenon: differential relation to fetal gender and maternal morphometry." in: European journal of obstetrics, gynecology, and reproductive biology, Vol. 86, Issue 2, pp. 151-7, 1999 (PubMed).

Gong, Bi, Pratley et al.: "Genomic structure and promoter analysis of the human obese gene." in: The Journal of biological chemistry, Vol. 271, Issue 8, pp. 3971-4, 1996 (PubMed).

Zhang, Proenca, Maffei et al.: "Positional cloning of the mouse obese gene and its human homologue." in: Nature, Vol. 372, Issue 6505, pp. 425-32, 1994 (PubMed).

Masuzaki, Ogawa, Isse et al.: "Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue." in: Diabetes, Vol. 44, Issue 7, pp. 855-8, 1995 (PubMed).

Validation Images
Catalog No. ABIN1047336
217.80 $
Plus shipping costs $45.00
Quantity
Price
50 μg
217.80 $
Plus shipping costs $45.00

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