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Human PRAME Protein expressed in Wheat germ - ABIN1316123
Luetkens, Kobold, Cao, Ristic, Schilling, Tams, Bartels, Templin, Bartels, Hildebrandt, Yousef, Marx, Haag, Bokemeyer, Kröger, Atanackovic: Functional autoantibodies against SSX-2 and NY-ESO-1 in multiple myeloma patients after allogeneic stem cell transplantation. in Cancer immunology, immunotherapy : CII 2014
the expansion of the PRAME family occurred in both autosomes and sex chromosomes
To investigate the impact of gene copy number variation on PRAME expression, plasma cells were sorted from 50 newly diagnosed multiple myeloma patients and 8 healthy volunteers to measure PRAME transcript levels and gene copy numbers by real-time quantitative polymerase chain reaction.
Tumor antigen PRAME is up-regulated by MZF1 (show ZFP42 Proteins) in cooperation with DNA hypomethylation in melanoma cells.
Results support the potential utility of NY-ESO-1 (show CTAG1B Proteins), PRAME, and MAGEA4 (show MAGEA4 Proteins) as targets for immunotherapy and as ancillary prognostic parameters in synovial sarcomas.
PRAME plays a role in preventing the invasion and metastasis of lung adenocarcinoma
PRAME is expressed in many primary and metastatic UMs (show TBX3 Proteins), and about half of the metastatic UMs (show TBX3 Proteins) coexpress PRAME and HLA class I (show MICA Proteins).
PRAME is a downstream factor of SOX17 (show SOX17 Proteins) and LIN28 (show LIN28A Proteins) in regulating pluripotency and suppressing somatic/germ cell differentiation in primordial germ cells, germ cell neoplasia in situ, and seminomas.
In line with its roles in controlling cell growth, RPAME regulates multiple critical cell-growth related genes, including IGF1R (show IGF1R Proteins) oncogene (show RAB1A Proteins). IGF1R (show IGF1R Proteins) up-regulation contributes to increase of cell growth upon the knockdown of PRAME.
This study demonstrates that PRAME functions as a tumor suppressor in breast cancer.
PRAME is an independent prognostic biomarker in Uveal melanoma , which identifies increased metastatic risk in patients with Class 1 or disomy 3 tumors.
Leukemias expressing high levels of PRAME had higher levels of cell death by regulating S100A4 (show S100A4 Proteins)/p53 (show TP53 Proteins) signaling.
This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.
preferentially expressed antigen in melanoma
, Opa-interacting protein OIP4
, cancer/testis antigen 130
, melanoma antigen preferentially expressed in tumors
, opa-interacting protein 4
, preferentially expressed antigen of melanoma