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Browse our PRAME Proteins (PRAME)

Full name:
Preferentially Expressed Antigen in Melanoma Proteins (PRAME)
On are 12 Preferentially Expressed Antigen in Melanoma (PRAME) Proteins from 7 different suppliers available. Additionally we are shipping PRAME Antibodies (57) and PRAME Kits (5) and many more products for this protein. A total of 86 PRAME products are currently listed.
4930534P07Rik, CT130, MAPE, OIP-4, OIP4, PRAME
list all proteins Gene Name GeneID UniProt
PRAME 23532 P78395
Mouse PRAME PRAME 75829  
Rat PRAME PRAME 680000  

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PRAME Proteins (PRAME) by Origin

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Top referenced PRAME Proteins

  1. Human PRAME Protein expressed in Wheat germ - ABIN1316123 : Luetkens, Kobold, Cao, Ristic, Schilling, Tams, Bartels, Templin, Bartels, Hildebrandt, Yousef, Marx, Haag, Bokemeyer, Kröger, Atanackovic: Functional autoantibodies against SSX-2 and NY-ESO-1 in multiple myeloma patients after allogeneic stem cell transplantation. in Cancer immunology, immunotherapy : CII 2014 (PubMed)

More Proteins for PRAME Interaction Partners

Cow (Bovine) Preferentially Expressed Antigen in Melanoma (PRAME) interaction partners

  1. the expansion of the PRAME family occurred in both autosomes and sex chromosomes

Human Preferentially Expressed Antigen in Melanoma (PRAME) interaction partners

  1. PRAME expression is considered as a poor prognostic parameter in HL.

  2. PRAME immunoreactivity in myeloid leukemia (show BCL11A Proteins) (ML) of Down syndrome (DS) is largely due to the non-blast components, while PRAME immunoreactivity in blasts of Transient abnormal myelopoiesis (TAM (show CCNA1 Proteins)) is not restricted to cases that progress to ML of DS.

  3. This study shows the prognostic significance of PRAME expression in diffuse large B-cell lymphoma patients treated with R-CHOP (show DDIT3 Proteins) therapy.

  4. results suggested that PRAME was a predictor for better outcome, could be a useful target for immunotherapy, and might represent a candidate marker for the monitoring of minimal residual disease

  5. elevated PRAME expression in head and neck squamous cell carcinoma

  6. PRAME and WT1 (show WT1 Proteins) transcripts constitute a good molecular marker combination for monitoring minimal residual disease in MDS (show PAFAH1B1 Proteins).

  7. PRAME impairs differentiation and increases proliferation likely via blocking retinoic acid receptor (show RARA Proteins) signaling.

  8. PRAME expression in leukaemic cell lines is upregulated by IFN gamma (show IFNG Proteins) and LPS (show IRF6 Proteins), suggesting a possible role in immune responses. PRAME associates with Elongin BC complexes by binding Elongin C (show TCEB1 Proteins), and co-localises to the Golgi network. Nuclear PRAME interacts with Histone H3 (show HIST3H3 Proteins). The results suggest that PRAME has dual roles in gene regulation in the nucleus and protein turnover trafficking in the Golgi

  9. The complex PRAME/EZH2 (show EZH2 Proteins) is able to repress TRAIL expression, in a cancer-specific manner; inhibition of PRAME/EZH2 (show EZH2 Proteins) releases apoptosis-mediating TRAIL. (Review)

  10. Knock-down of PRAME increases retinoic acid signaling and cytotoxic drug sensitivity of Hodgkin lymphoma cells.

PRAME Protein Profile

Protein Summary

This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.

Alternative names and synonyms associated with PRAME

  • preferentially expressed antigen in melanoma (PRAME)
  • preferentially expressed antigen in melanoma (Prame)
  • 4930534P07Rik protein
  • CT130 protein
  • MAPE protein
  • OIP-4 protein
  • OIP4 protein
  • PRAME protein

Protein level used designations for PRAME

preferentially expressed antigen in melanoma , Opa-interacting protein OIP4 , cancer/testis antigen 130 , melanoma antigen preferentially expressed in tumors , opa-interacting protein 4 , preferentially expressed antigen of melanoma

528601 Bos taurus
23532 Homo sapiens
785023 Bos taurus
75829 Mus musculus
680000 Rattus norvegicus
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