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Human PRAME Protein expressed in Wheat germ - ABIN1316123
Luetkens, Kobold, Cao, Ristic, Schilling, Tams, Bartels, Templin, Bartels, Hildebrandt, Yousef, Marx, Haag, Bokemeyer, Kröger, Atanackovic: Functional autoantibodies against SSX-2 and NY-ESO-1 in multiple myeloma patients after allogeneic stem cell transplantation. in Cancer immunology, immunotherapy : CII 2014
the expansion of the PRAME family occurred in both autosomes and sex chromosomes
In line with its roles in controlling cell growth, RPAME regulates multiple critical cell-growth related genes, including IGF1R (show IGF1R Proteins) oncogene (show RAB1A Proteins). IGF1R (show IGF1R Proteins) up-regulation contributes to increase of cell growth upon the knockdown of PRAME.
This study demonstrates that PRAME functions as a tumor suppressor in breast cancer.
PRAME is an independent prognostic biomarker in Uveal melanoma , which identifies increased metastatic risk in patients with Class 1 or disomy 3 tumors.
Leukemias expressing high levels of PRAME had higher levels of cell death by regulating S100A4 (show S100A4 Proteins)/p53 (show TP53 Proteins) signaling.
Our results suggest that the leukemias expressing high levels of PRAME has favorable prognosis
PRAME expression is considered as a poor prognostic parameter in HL.
PRAME immunoreactivity in myeloid leukemia (show BCL11A Proteins) (ML) of Down syndrome (DS) is largely due to the non-blast components, while PRAME immunoreactivity in blasts of Transient abnormal myelopoiesis (TAM (show CCNA1 Proteins)) is not restricted to cases that progress to ML of DS.
This study shows the prognostic significance of PRAME expression in diffuse large B-cell lymphoma patients treated with R-CHOP (show DDIT3 Proteins) therapy.
results suggested that PRAME was a predictor for better outcome, could be a useful target for immunotherapy, and might represent a candidate marker for the monitoring of minimal residual disease
elevated PRAME expression in head and neck squamous cell carcinoma
This gene encodes an antigen that is predominantly expressed in human melanomas and that is recognized by cytolytic T lymphocytes. It is not expressed in normal tissues, except testis. This expression pattern is similar to that of other CT antigens, such as MAGE, BAGE and GAGE. However, unlike these other CT antigens, this gene is also expressed in acute leukemias. Five alternatively spliced transcript variants encoding the same protein have been observed for this gene.
preferentially expressed antigen in melanoma
, Opa-interacting protein OIP4
, cancer/testis antigen 130
, melanoma antigen preferentially expressed in tumors
, opa-interacting protein 4
, preferentially expressed antigen of melanoma