Browse our anti-Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) Antibodies

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anti-Gem (Nuclear Organelle) Associated Protein 2 Antibodies (GEMIN2)
On www.antibodies-online.com are 82 Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) Antibodies from 21 different suppliers available. Additionally we are shipping Gem (Nuclear Organelle) Associated Protein 2 Proteins (6) and Gem (Nuclear Organelle) Associated Protein 2 Kits (1) and many more products for this protein. A total of 99 Gem (Nuclear Organelle) Associated Protein 2 products are currently listed.
Synonyms:
1700012N19Rik, HSPC082, SIP-1, Sip1, SIP1-delta, SMADIP1, ZFHX1B
list all antibodies Gene Name GeneID UniProt
GEMIN2 8487 O14893
GEMIN2 66603 Q9CQQ4
GEMIN2 84404 Q9QZP1

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Top referenced anti-Gem (Nuclear Organelle) Associated Protein 2 Antibodies

  1. Mouse (Murine) Monoclonal GEMIN2 Primary Antibody for ICC, FACS - ABIN108541 : Liu, Fischer, Wang, Dreyfuss: The spinal muscular atrophy disease gene product, SMN, and its associated protein SIP1 are in a complex with spliceosomal snRNP proteins. in Cell 1997 (PubMed)
    Show all 8 references for 108541

  2. Human Monoclonal GEMIN2 Primary Antibody for IF, IP - ABIN2668496 : Oztas, Avci, Ozcan, Sayan, Tulchinsky, Yagci: Novel monoclonal antibodies detect Smad-interacting protein 1 (SIP1) in the cytoplasm of human cells from multiple tumor tissue arrays. in Experimental and molecular pathology 2010 (PubMed)
    Show all 2 references for 2668496

  3. Human Monoclonal GEMIN2 Primary Antibody for IF, WB - ABIN968440 : Fischer, Liu, Dreyfuss: The SMN-SIP1 complex has an essential role in spliceosomal snRNP biogenesis. in Cell 1997 (PubMed)
    Show all 2 references for 968440

  4. Cow (Bovine) Polyclonal GEMIN2 Primary Antibody for WB - ABIN2778712 : Gregory, Bert, Paterson, Barry, Tsykin, Farshid, Vadas, Khew-Goodall, Goodall: The miR-200 family and miR-205 regulate epithelial to mesenchymal transition by targeting ZEB1 and SIP1. in Nature cell biology 2008 (PubMed)

More Antibodies against Gem (Nuclear Organelle) Associated Protein 2 Interaction Partners

Human Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) interaction partners

  1. siRNAs targeting Ets1 (show ETS1 Antibodies) repressed expression of ZEB1 (show ZEB1 Antibodies)/ZEB2 (show ZEB2 Antibodies).

  2. overexpression of miR (show MLXIP Antibodies)-218 in H1299 increased chemosensitivity of cells to cisplatin treatment through suppression of Slug (show SNAI2 Antibodies) and ZEB2 (show ZEB2 Antibodies). These findings highlight an important role of miR (show MLXIP Antibodies)-218 in the regulation of EMT (show ITK Antibodies)-related traits and metastasis of lung cancer in part by modulation of Slug (show SNAI2 Antibodies)/ZEB2 (show ZEB2 Antibodies) signaling, and provide a potential therapeutic strategy by targeting miR (show MLXIP Antibodies)-218 in lung cancer.

  3. results revealed the critical regulatory role of miR (show MLXIP Antibodies)-145 in hepatic stellates cells activation and implied miR (show MLXIP Antibodies)-145 as a potential candidate for therapy of hepatic fibrosis by regulation of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) through targeting ZEB2 (show ZEB2 Antibodies)

  4. Specific mutations in the yeast Sm protein ring expose a requirement for assembly factor Brr1, a homolog of human Gemin2.

  5. Results show that inhibition of miR (show MLXIP Antibodies)-141 enhanced colorectal cancer (CRC (show CALR Antibodies)) cell proliferation and migration through significant increase of its target's expression, ZEB2 (show ZEB2 Antibodies) and phosphorylation of HGFR.

  6. This Gene-based tests suggest evidence of association with related genes, ZEB2 (show ZEB2 Antibodies), RND3 (show RND3 Antibodies), MCTP1, CTBP2 (show CTBP2 Antibodies), and beta EEG.

  7. Collectively, the results demonstrate that Zeb2 (show ZEB2 Antibodies) controls adult hematopoietic differentiation and lineage fidelity through widespread modulation of dominant signaling pathways that may contribute to blood disorders.

  8. ZEB2 (show ZEB2 Antibodies) transcriptionally represses genes that regulate myeloid differentiation, including genes involved in cell adhesion and migration; epigenetic silencing of the miR (show MLXIP Antibodies)-200 family microRNAs affects ZEB2 (show ZEB2 Antibodies) expression.

  9. This study identified the lysine-specific demethylase (show MBD2 Antibodies) KDM1A (show KDM1A Antibodies) as a novel interaction partner of ZEB2 (show ZEB2 Antibodies) and demonstrated that mouse and human T-cell acute lymphoblastic leukemia cells with increased ZEB2 (show ZEB2 Antibodies) levels critically depend on KDM1A (show KDM1A Antibodies) activity for survival.

  10. e revealed there was a reciprocal repression between MALAT1 and miR-204. ZEB2 was identified as a downstream target of miR-204 and MALAT1 exerted its function mainly through the miR-204/ZEB2 axis. Our findings suggested that MALAT1 may serve as a new diagnostic biomarker and therapy target for breast cancer.

Mouse (Murine) Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) interaction partners

  1. utilised a targeted screen to identify mRNA associated with SMN (show STMN1 Antibodies), Gemin2 and Gemin3 (show DDX20 Antibodies) in the cytoplasm of a human neuroblastoma (show ARHGEF16 Antibodies) cell line, SHSY5Y

  2. Gene targeting in mice reveals a correlation between defects in the biogenesis of U snRNPs and motoneuron cell death (gemin2; SMN interacting protein 1)

Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2) Antigen Profile

Antigen Summary

The protein encoded by this gene is a member of the Zfh1 family of 2-handed zinc finger/homeodomain proteins. It is located in the nucleus and functions as a DNA-binding transcriptional repressor that interacts with activated SMADs. Mutations in this gene are associated with Hirschsprung disease/Mowat-Wilson syndrome. Alternatively spliced transcript variants have been found for this gene.

Alternative names and synonyms associated with Gem (Nuclear Organelle) Associated Protein 2 (GEMIN2)

  • gem (nuclear organelle) associated protein 2 (gemin2) antibody
  • gem (nuclear organelle) associated protein 2 (GEMIN2) antibody
  • gem (nuclear organelle) associated protein 2 (Gemin2) antibody
  • zinc finger E-box binding homeobox 2 (ZEB2) antibody
  • 1700012N19Rik antibody
  • HSPC082 antibody
  • SIP-1 antibody
  • Sip1 antibody
  • SIP1-delta antibody
  • SMADIP1 antibody
  • ZFHX1B antibody

Protein level used designations for GEMIN2

SMN-interacting protein 1 , Survival of motor neuron protein-interacting protein 1 , component of gems 2 , gem-associated protein 2 , gemin-2 , survival of motor neuron protein interacting protein 1 , SMN interacting protein 1-delta , survival of motor neuron protein-interacting protein 1 , survivor of motor neuron protein interacting protein 1 , SMN interacting protein-1 , SMAD interacting protein 1 , Smad-interacting protein 1 , zinc finger E-box-binding homeobox 2 , zinc finger homeobox 1b

GENE ID SPECIES
494588 Xenopus laevis
8487 Homo sapiens
510259 Bos taurus
66603 Mus musculus
84404 Rattus norvegicus
423336 Gallus gallus
610087 Canis lupus familiaris
9839 Homo sapiens
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