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anti-Human MUSK antibody for Immunocytochemistry

Recommended MUSK Antibody (supplied by: Log in to see )

Antigen
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) Antibodies
  • fj98e12
  • Mdk4
  • Mlk
  • muscle
  • MUSK
  • MuSK
  • musk-A
  • Nsk1
  • Nsk2
  • Nsk3
  • si:busm1-57f23.3
  • si:dz46m7.2
  • si:dz57f23.3
  • unp
  • wu:fj98e12
  • zgc:63467
Epitope
AA 24-209
25
25
14
10
6
5
5
4
3
3
1
1
1
1
1
Reactivity
Human
107
41
29
2
Host
Mouse
92
23
3
Clonality
Monoclonal
Conjugate
This MUSK antibody is un-conjugated
6
6
5
4
4
4
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA
88
68
55
26
19
12
11
4
4
2
2
1
1
Supplier
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Catalog No. ABIN969299
$ 393.80
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.6663565 ABIN1844447 ICC IF IHC ELISA Mouse IgG1 AA 24-209 Log in to see
0.0009962841 ABIN4336818 ELISA ICC IF IHC IHC (fro) IHC (p) Mouse IgG1 Log in to see 10A4

Top referenced anti-MUSK antibody for Immunocytochemistry

Similar anti-MUSK Antibodies

Application / Reactivity Human
ELISA 61 Antibodies
ELISA (Capture) 1 Antibodies
Enzyme Immunoassay (EIA) 4 Antibodies
Flow Cytometry (FACS) 26 Antibodies
Immunocytochemistry (ICC) 3 Antibodies
Immunofluorescence (IF) 11 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies
Immunohistochemistry (IHC) 53 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 16 Antibodies
Western Blotting (WB) 77 Antibodies

General

Antigen Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) Antibodies
Epitope AA 24-209
(25), (25), (14), (10), (6), (5), (5), (4), (3), (3), (1), (1), (1), (1), (1)
Reactivity Human
(107), (41), (29), (2)
Host Mouse
(92), (23), (3)
Clonality (Clone)
Monoclonal   ( )
Conjugate This MUSK antibody is un-conjugated
(6), (6), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunocytochemistry (ICC), Immunohistochemistry (IHC), ELISA
(88), (68), (55), (26), (19), (12), (11), (4), (4), (2), (2), (1), (1)
Pubmed 1 reference available
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Product Details anti-MUSK Antibody

Target Details MUSK Application Details Handling References for anti-MUSK Antibody (ABIN969299) Images
Purification Ascites
Immunogen Purified recombinant extracellular fragment of human MUSK (AA 24-209) fused with hIgGFc tag expressed in HEK293 cell line.
Clone 10A4
Isotype IgG1

Target Details MUSK

Product Details anti-MUSK Antibody Application Details Handling References for anti-MUSK Antibody (ABIN969299) Images back to top
Antigen
Alternative Name MUSK (MUSK Antibody Abstract)
Background MuSK (for Muscle Specific Kinase) is a receptor tyrosine kinase required for the formation of the neuromuscular junction (NMJ). It induces cellular signaling by causing the addition of phosphate molecules to particular tyrosines on itself, and on proteins which bind the cytoplasmic domain of the receptor. It is activated by a nerve-derived proteoglycan called agrin. During development, the growing end of motor neuron axons secrete a protein called agrin.This protein binds to several receptors on the surface of skeletal muscle. The receptor which seems to be required for formation of the neuromuscular junction (NMJ), which comprises the nerve-muscle synapse is called MuSK. MUSK mutations lead to decreased agrin-dependent AchR aggregation, a critical step in the formation of the neuromuscular junction.
Molecular Weight 97 kDa
Gene ID 4593
HGNC 4593
Research Area Extracellular Matrix, Tyrosine Kinases, Kinases/Phosphatases
Pathways RTK Signaling

Application Details

Product Details anti-MUSK Antibody Target Details MUSK Handling References for anti-MUSK Antibody (ABIN969299) Images back to top
Application Notes Recommended Dilution:
ELISA: 1/10000, IHC: 1/200 - 1/1000, ICC: 1/200 - 1/1000
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only

Handling

Product Details anti-MUSK Antibody Target Details MUSK Application Details References for anti-MUSK Antibody (ABIN969299) Images back to top
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.

References for anti-MUSK Antibody (ABIN969299)

Product Details anti-MUSK Antibody Target Details MUSK Application Details Handling Images back to top
Product cited in:

Boneva, Frenkian-Cuvelier, Bidault, Brenner, Berrih-Aknin: "Major pathogenic effects of anti-MuSK antibodies in myasthenia gravis." in: Journal of neuroimmunology, Vol. 177, Issue 1-2, pp. 119-31, 2006

Images

Product Details anti-MUSK Antibody Target Details MUSK Application Details Handling References for anti-MUSK Antibody (ABIN969299) back to top
Supplier Images
Immunocytochemistry (ICC) image for anti-MUSK antibody (Muscle, Skeletal, Receptor Tyrosine Kinase) (AA 24-209) (ABIN969299) Figure 1: Confocal immunofluorescence analysis of HEK293 cells trasfected with extrac...
Immunohistochemistry (IHC) image for anti-MUSK antibody (Muscle, Skeletal, Receptor Tyrosine Kinase) (AA 24-209) (ABIN969299) Figure 2: Immunohistochemical analysis of paraffin-embedded human lung cancer (A), mu...