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anti-Mouse (Murine) MUSK antibody for Immunofluorescence (Paraffin-embedded Sections)

Recommended MUSK Antibody (supplied by: Log in to see )

Antigen
Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) Antibodies
  • fj98e12
  • Mdk4
  • Mlk
  • muscle
  • MUSK
  • MuSK
  • musk-A
  • Nsk1
  • Nsk2
  • Nsk3
  • si:busm1-57f23.3
  • si:dz46m7.2
  • si:dz57f23.3
  • unp
  • wu:fj98e12
  • zgc:63467
Reactivity
Human, Mouse (Murine), Rat (Rattus)
107
39
27
1
Host
Rabbit
90
24
3
Clonality
Polyclonal
Conjugate
This MUSK antibody is un-conjugated
6
6
5
4
4
4
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
86
69
56
26
17
11
10
4
4
2
1
1
1
Supplier
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Catalog No. ABIN1386240
$ 269.50
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
0.00088487717 ABIN1397491 IF (p) Alexa Fluor 555 Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN1397492 IF (p) Alexa Fluor 647 Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN1397489 IF (p) Alexa Fluor 350 Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN1397494 IF (p) FITC Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN1397490 IF (p) Alexa Fluor 488 Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN1415362 IF (p) Cy3 Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN1415363 IF (p) Cy5 Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN1415365 IF (p) Cy7 Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN1415364 IF (p) Cy5.5 Rabbit IgG Log in to see Polyclonal
0.00088487717 ABIN2804392 IF (p) Alexa Fluor 594 Rabbit IgG AA 260-310 Log in to see Polyclonal

Similar anti-MUSK Antibodies

Application / Reactivity Rat (Rattus) Mouse (Murine) Human
ELISA 7 Antibodies 14 Antibodies 61 Antibodies
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antibodies 11 Antibodies
Immunohistochemistry (IHC) 9 Antibodies 11 Antibodies
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 3 Antibodies 6 Antibodies
Immunoprecipitation (IP) 1 Antibodies 1 Antibodies
Western Blotting (WB) 13 Antibodies 23 Antibodies
Flow Cytometry (FACS) 3 Antibodies
Immunochromatography (IC) 1 Antibodies
Immunocytochemistry (ICC) 1 Antibodies
Immunofluorescence (IF) 2 Antibodies
Immunohistochemistry (Frozen Sections) (IHC (fro)) 1 Antibodies

General

Antigen Muscle, Skeletal, Receptor Tyrosine Kinase (MUSK) Antibodies
Reactivity Human, Mouse (Murine), Rat (Rattus)
(107), (39), (27), (1)
Host Rabbit
(90), (24), (3)
Clonality
Polyclonal
Conjugate This MUSK antibody is un-conjugated
(6), (6), (5), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(86), (69), (56), (26), (17), (11), (10), (4), (4), (2), (1), (1), (1)
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Product Details anti-MUSK Antibody

Target Details MUSK Application Details Handling Images
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human MUSK
Isotype IgG

Target Details MUSK

Product Details anti-MUSK Antibody Application Details Handling Images back to top
Antigen
Alternative Name Musk (MUSK Antibody Abstract)
Background

Receptor tyrosine kinase which plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ), the synapse between the motor neuron and the skeletal muscle (PubMed:25537362). Recruitment of AGRIN by LRP4 to the MUSK signaling complex induces phosphorylation and activation of MUSK, the kinase of the complex. The activation of MUSK in myotubes regulates the formation of NMJs through the regulation of different processes including the specific expression of genes in subsynaptic nuclei, the reorganization of the actin cytoskeleton and the clustering of the acetylcholine receptors (AChR) in the postsynaptic membrane. May regulate AChR phosphorylation and clustering through activation of ABL1 and Src family kinases which in turn regulate MUSK. DVL1 and PAK1 that form a ternary complex with MUSK are also important for MUSK-dependent regulation of AChR clustering. May positively regulate Rho family GTPases through FNTA. Mediates the phosphorylation of FNTA which promotes prenylation, recruitment to membranes and activation of RAC1 a regulator of the actin cytoskeleton and of gene expression. Other effectors of the MUSK signaling include DNAJA3 which functions downstream of MUSK. May also play a role within the central nervous system by mediating cholinergic responses, synaptic plasticity and memory formation (By similarity).

Subcellular location: Extracellular


Synonyms: CMS9, FADS, Muscle, skeletal receptor tyrosine-protein kinase, Muscle-specific tyrosine-protein kinase receptor, MuSK, Muscle-specific kinase receptor
Gene ID 4593
HGNC 0
UniProt O15146
Research Area Extracellular Matrix, Tyrosine Kinases, Kinases/Phosphatases
Pathways RTK Signaling

Application Details

Product Details anti-MUSK Antibody Target Details MUSK Handling Images back to top
Application Notes WB(1:100-1000), IHC-P(1:100-500), IF(IHC-P)(1:50-200)
Restrictions For Research Use only

Handling

Product Details anti-MUSK Antibody Target Details MUSK Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-MUSK Antibody Target Details MUSK Application Details Handling back to top
Supplier Images
Immunohistochemistry (IHC) image for anti-MUSK antibody (Muscle, Skeletal, Receptor Tyrosine Kinase) (ABIN1386240) Formalin-fixed and paraffin embedded mouse embryonic muscle labeled with Anti-MUSK Po...