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|Application / Reactivity||Mouse (Murine)|
|Enzyme Immunoassay (EIA)||2 Antibodies|
|Flow Cytometry (FACS)||26 Antibodies|
|Functional Studies (Func)||2 Antibodies|
|Immunochromatography (IC)||1 Antibodies|
|Immunocytochemistry (ICC)||6 Antibodies|
|Immunofluorescence (IF)||14 Antibodies|
|Immunofluorescence (Paraffin-embedded Sections) (IF (p))||59 Antibodies|
|Immunohistochemistry (IHC)||41 Antibodies|
|Immunohistochemistry (Formalin-fixed Sections) (IHC (f))||1 Antibodies|
|Immunohistochemistry (Frozen Sections) (IHC (fro))||4 Antibodies|
|Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))||27 Antibodies|
|Immunoprecipitation (IP)||2 Antibodies|
|Western Blotting (WB)||95 Antibodies|
|Antigen||Platelet-Derived Growth Factor Receptor, alpha Polypeptide (PDGFRA) Antibodies|
|Reactivity||Mouse (Murine) Alternatives|
|Conjugate||This PDGFRA antibody is conjugated to APC Alternatives|
Immunocytochemistry (ICC), Flow Cytometry (FACS), Western Blotting (WB)
|6 references available|
|Supplier||Log in to see|
Product Details anti-PDGFRA AntibodyTarget Details PDGFRA Application Details Handling References for anti-PDGFRA Antibody (ABIN2658489) Images
|Purification||The antibody was purified by affinity chromatography, and conjugated with APC under optimal conditions. The solution is free of unconjugated APC and unconjugated antibody.|
Target Details PDGFRAProduct Details anti-PDGFRA Antibody Application Details Handling References for anti-PDGFRA Antibody (ABIN2658489) Images back to top
|Alternative Name||CD140a (PDGFRA Antibody Abstract)|
|Background||Platelet-derived growth factor receptor-α (PDGFR-α), CD140a, is one of two receptors for platelet-derived growth factors (PDGFs) and binds to all isoforms of PDGFs: PDGF-AA, PDGF-AB, and PDGF-BB. PDGFRa is a receptor tyrosine kinase that forms homodimers or heterodimers on the surface upon ligand binding and phosphorylates substrates. PDGFRs consist of either homodimers of α/α, β/β, or heterodimers of α/β. PDGF receptors, α and β, are single glycoproteins with intracellular tyrosine kinase domain. Their ligand, PDGF, is a mitogen for connective tissue and glial cells. CD140a is expressed on embryonic tissues and mesenchymal-derived cells of adult mice. PDGF plays a role in wound healing and acts as a chemoattractant for fibroblasts, smooth muscle cells, glial cells, monocytes, and neutrophils.|
|Research Area||CD Antigens, Surface Receptors of Immune Cells|
|Pathways||RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway|
Application DetailsProduct Details anti-PDGFRA Antibody Target Details PDGFRA Handling References for anti-PDGFRA Antibody (ABIN2658489) Images back to top
|Application Notes||Optimal working dilution should be determined by the investigator.|
|Restrictions||For Research Use only|
HandlingProduct Details anti-PDGFRA Antibody Target Details PDGFRA Application Details References for anti-PDGFRA Antibody (ABIN2658489) Images back to top
|Buffer||Phosphate-buffered solution, pH 7.2, containing 0.09 % sodium azide.|
|Precaution of Use||This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.|
|Handling Advice||Protect from prolonged exposure to light. Do not freeze.|
|Storage Comment||The antibody solution should be stored undiluted between 2°C and 8°C.|
References for anti-PDGFRA Antibody (ABIN2658489)Product Details anti-PDGFRA Antibody Target Details PDGFRA Application Details Handling Images back to top
Wang, Kissig, Rajakumari et al.: "Ebf2 is a selective marker of brown and beige adipogenic precursor cells." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 111, Issue 40, pp. 14466-71, 2014 (PubMed).
Liao, Akazawa, Tamagawa et al.: "Cardiac mast cells cause atrial fibrillation through PDGF-A-mediated fibrosis in pressure-overloaded mouse hearts." in: The Journal of clinical investigation, Vol. 120, Issue 1, pp. 242-53, 2010 (PubMed).
Mukouyama, Deneen, Lukaszewicz et al.: "Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 103, Issue 5, pp. 1551-6, 2006 (PubMed).
Miyawaki, Uemura, Dezawa et al.: "Tlx, an orphan nuclear receptor, regulates cell numbers and astrocyte development in the developing retina." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 24, Issue 37, pp. 8124-34, 2004 (PubMed).
Takakura, Yoshida, Ogura et al.: "PDGFR alpha expression during mouse embryogenesis: immunolocalization analyzed by whole-mount immunohistostaining using the monoclonal anti-mouse PDGFR alpha antibody APA5." in: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 45, Issue 6, pp. 883-93, 1997 (PubMed).
Takakura, Yoshida, Kunisada et al.: "Involvement of platelet-derived growth factor receptor-alpha in hair canal formation." in: The Journal of investigative dermatology, Vol. 107, Issue 5, pp. 770-7, 1996 (PubMed).
ImagesProduct Details anti-PDGFRA Antibody Target Details PDGFRA Application Details Handling References for anti-PDGFRA Antibody (ABIN2658489) back to top