anti-Mouse (Murine) TSC2 antibody for Enzyme Immunoassay

Recommended TSC2 Antibody (supplied by: Log in to see )

Antigen
Tuberous Sclerosis 2 (TSC2) Antibodies
  • TSC2
  • fc16b02
  • tuberin
  • wu:fc16b02
  • LAM
  • TSC4
  • Nafld
  • Tcs2
  • Rc
  • tuberous sclerosis 2
  • tuberous sclerosis complex 2 (TSC2)
  • TSC2
  • AaeL_AAEL007712
  • tsc2
  • PGTG_00159
  • Tsc2
Epitope
C-Term
57
41
40
36
33
30
29
25
21
20
20
20
20
20
20
20
20
20
20
20
18
15
15
15
15
15
13
8
8
8
7
7
6
5
4
4
3
3
3
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
558
412
243
13
9
4
4
3
1
1
1
1
Host
Rabbit
727
26
Clonality
Polyclonal
Conjugate
This TSC2 antibody is un-conjugated
51
51
51
43
42
42
10
10
9
9
9
9
9
9
9
9
9
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Western Blotting (WB)
396
287
230
143
119
95
68
24
7
6
5
4
2
1
Supplier
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Catalog No. ABIN5555393
$ 375.38
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
1 ABIN5555394 EIA IF WB Rabbit IgG N-Term Log in to see Polyclonal

General

Antigen Tuberous Sclerosis 2 (TSC2) Antibodies
Epitope C-Term
(57), (41), (40), (36), (33), (30), (29), (25), (21), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (18), (15), (15), (15), (15), (15), (13), (8), (8), (8), (7), (7), (6), (5), (4), (4), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine)
(558), (412), (243), (13), (9), (4), (4), (3), (1), (1), (1), (1)
Host Rabbit
(727), (26)
Clonality
Polyclonal
Conjugate This TSC2 antibody is un-conjugated
(51), (51), (51), (43), (42), (42), (10), (10), (9), (9), (9), (9), (9), (9), (9), (9), (9), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Enzyme Immunoassay (EIA), Western Blotting (WB)
(396), (287), (230), (143), (119), (95), (68), (24), (7), (6), (5), (4), (2), (1)
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Product Details anti-TSC2 Antibody

Target Details TSC2 Application Details Handling Images
Specificity This antibody detects Tuberin / TSC2 at C-term.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse
Purification Peptide affinity chromatography
Immunogen TSC2 antibody was raised against a 15 amino acid peptide from near the carboxy-terminus of human TSC2.
Isotype IgG

Target Details TSC2

Product Details anti-TSC2 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Tuberin / TSC2 (TSC2 Antibody Abstract)
Background Tuberous sclerosis complex (TSC) is an autosomal dominant tumor syndrome caused by mutations in either of the TSC1 or TSC2 tumor suppressor genes. The products of these genes form a protein complex that indirectly decreases the signaling of the mammalian Target of Rapamycin (TOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors (reviewed in 1,2). TOR activity is stimulated by Rheb, a member of the Ras superfamily of G-proteins, when the GTP/GDP ratio bound to Rheb is high (3). Immunoprecipitated TSC1/TSC2 has been shown to stimulate Rheb GTPase activity in vitro (4), suggesting that the TSC1/TSC2 complex decreases the ability of Rheb to stimulate TOR activity. This is supported by experiments showing that overexpression of TSC1 and TSC2 results in a significant decrease in the GTP/GDP ratio bound to Rheb and the inhibition of cell growth (4,5). At least three isoforms of TSC2 exist.Synonyms: TSC4, Tuberous sclerosis 2 protein
Gene ID 7249
NCBI Accession NP_000539
Pathways RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus

Application Details

Product Details anti-TSC2 Antibody Target Details TSC2 Handling Images back to top
Application Notes ELISA. Western blot: 1 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions For Research Use only

Handling

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details Images back to top
Buffer PBS containing 0.02 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store at 2 - 8 °C for up to one month or (in aliquots) at -20 °C for longer.