anti-Mouse (Murine) TSC2 antibody for Immunohistochemistry (Paraffin-embedded Sections)

Recommended TSC2 Antibody (supplied by: Log in to see )

Antigen
Tuberous Sclerosis 2 (TSC2) Antibodies
  • TSC2
  • fc16b02
  • tuberin
  • wu:fc16b02
  • LAM
  • TSC4
  • Nafld
  • Tcs2
  • Rc
  • tuberous sclerosis 2
  • tuberous sclerosis complex 2 (TSC2)
  • TSC2
  • AaeL_AAEL007712
  • tsc2
  • PGTG_00159
  • Tsc2
Epitope
pSer1798
57
40
40
36
33
29
29
25
23
21
20
20
20
20
20
20
20
20
20
20
18
15
15
15
15
15
13
9
8
8
7
7
6
5
4
4
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
557
412
242
13
9
4
4
3
1
1
1
1
Host
Rabbit
726
26
Clonality
Polyclonal
Conjugate
This TSC2 antibody is un-conjugated
51
51
51
43
42
42
10
10
9
9
9
9
9
9
9
9
9
1
1
1
1
1
1
1
1
1
Application
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
396
287
230
142
118
93
67
23
7
7
5
4
2
1
Options
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Catalog No. ABIN712121
$ 317.90
Plus shipping costs $45.00
Relevance Score ABIN Application Conjugate Host Isotype Epitope Supplier Clonality References Details
11.569717 ABIN498904 IHC (p) Rabbit Log in to see Polyclonal
11.569717 ABIN498905 IHC (p) Rabbit Log in to see Polyclonal
11.569717 ABIN498813 IHC (p) Rabbit pSer939 Log in to see Polyclonal
11.569717 ABIN498814 IHC (p) Rabbit pThr1462 Log in to see Polyclonal
11.569717 ABIN214015 IHC (p) WB Rabbit C-Term Log in to see Polyclonal
11.569717 ABIN746438 IF (p) IHC (p) WB Rabbit IgG pThr927 Log in to see Polyclonal
11.569717 ABIN712151 IF (p) IHC (p) WB Rabbit IgG pSer1418 Log in to see Polyclonal
1 ABIN701200 IF (p) IHC (p) Rabbit IgG AA 1600-1650 Log in to see Polyclonal 1
1 ABIN3043498 IHC (p) WB Rabbit IgG AA 1611-1807 Log in to see Polyclonal
1 ABIN272089 IHC (p) WB Rabbit Log in to see Polyclonal
1 ABIN272090 IHC (p) Rabbit Log in to see Polyclonal
1 ABIN302895 IHC (p) WB Rabbit Log in to see Polyclonal
1 ABIN303312 IF IHC (p) WB Rabbit N-Term Log in to see Polyclonal
1 ABIN701209 IHC (p) HRP Rabbit IgG AA 1600-1650 Log in to see Polyclonal
1 ABIN2888711 IHC (p) ELISA Rabbit IgG AA 1428-1477 Log in to see Polyclonal
1 ABIN2888710 IF IHC (p) ELISA WB Rabbit IgG AA 905-954 Log in to see Polyclonal
1 ABIN214540 ICC IHC (p) WB Rabbit N-Term Log in to see Polyclonal
1 ABIN746657 IHC (p) HRP Rabbit IgG pSer1254 Log in to see Polyclonal
1 ABIN746387 IHC (p) WB HRP Rabbit IgG pSer1387 Log in to see Polyclonal
1 ABIN746447 IHC (p) WB HRP Rabbit IgG pThr927 Log in to see Polyclonal

General

Antigen Tuberous Sclerosis 2 (TSC2) Antibodies
Epitope pSer1798
(57), (40), (40), (36), (33), (29), (29), (25), (23), (21), (20), (20), (20), (20), (20), (20), (20), (20), (20), (20), (18), (15), (15), (15), (15), (15), (13), (9), (8), (8), (7), (7), (6), (5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity Human, Mouse (Murine), Rat (Rattus)
(557), (412), (242), (13), (9), (4), (4), (3), (1), (1), (1), (1)
Host Rabbit
(726), (26)
Clonality
Polyclonal
Conjugate This TSC2 antibody is un-conjugated
(51), (51), (51), (43), (42), (42), (10), (10), (9), (9), (9), (9), (9), (9), (9), (9), (9), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(396), (287), (230), (142), (118), (93), (67), (23), (7), (7), (5), (4), (2), (1)
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Product Details anti-TSC2 Antibody

Target Details TSC2 Application Details Handling Images
Specificity Phosphorylation site corresponds to Ser1805 in mouse and Ser1800 in rat.
Purification Purified by Protein A.
Immunogen KLH conjugated synthetic phosphopeptide derived from human Tuberin around the phosphorylation site of Ser1798
Isotype IgG

Target Details TSC2

Product Details anti-TSC2 Antibody Application Details Handling Images back to top
Antigen
Alternative Name Tsc2 (TSC2 Antibody Abstract)
Background

In complex with TSC1, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling. Stimulates weakly the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 in vitro. Mutations in TSC2 lead to constitutive activation of RAP1A in tumors.

Subcellular location: Cytoplasm, Cell membrane

Synonyms: LAM, TSC4, PPP1R160, Tuberin, Tuberous sclerosis 2 protein, TSC2

Gene ID 7249
UniProt P49815
Pathways RTK Signaling, AMPK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Regulation of Cell Size, Tube Formation, Protein targeting to Nucleus

Application Details

Product Details anti-TSC2 Antibody Target Details TSC2 Handling Images back to top
Application Notes WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Restrictions For Research Use only

Handling

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details Images back to top
Format Liquid
Concentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Storage -20 °C
Storage Comment Store at -20°C
Expiry Date 12 months

Images

Product Details anti-TSC2 Antibody Target Details TSC2 Application Details Handling back to top
Supplier Images
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Tuberous Sclerosis 2 (TSC2) (pSer1798) antibody (ABIN712121) Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti-TSC2(Ser1798)...