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anti-Human IQGAP1 Antibodies:
anti-Rat (Rattus) IQGAP1 Antibodies:
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Dog (Canine) Monoclonal IQGAP1 Primary Antibody for IF, IP - ABIN968063
Hart, Callow, Souza, Polakis: IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. in The EMBO journal 1996
Show all 5 Pubmed References
Dog (Canine) Monoclonal IQGAP1 Primary Antibody for IF, IP - ABIN968064
Kuroda, Fukata, Kobayashi, Nakafuku, Nomura, Iwamatsu, Kaibuchi: Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1. in The Journal of biological chemistry 1996
Show all 5 Pubmed References
Mouse (Murine) Polyclonal IQGAP1 Primary Antibody for ELISA, WB - ABIN314835
Bi, Mancias, Goldberg: Insights into COPII coat nucleation from the structure of Sec23.Sar1 complexed with the active fragment of Sec31. in Developmental cell 2007
Human Polyclonal IQGAP1 Primary Antibody for ELISA, WB - ABIN4327480
Ren, Li, Sacks: IQGAP1 integrates Ca2+/calmodulin and B-Raf signaling. in The Journal of biological chemistry 2008
Human Polyclonal IQGAP1 Primary Antibody for IF (cc), IF (p) - ABIN737796
Fang, Zhang, Liu, Li, Zhou, Song, Zhao, Feng, Zhang, Li, Wen: PAX6 downregulates miR-124 expression to promote cell migration during embryonic stem cell differentiation. in Stem cells and development 2014
Human Polyclonal IQGAP1 Primary Antibody for ICC, IF - ABIN438475
Sun, Kapuria, Peterson, Fang, Bornmann, Bartholomeusz, Talpaz, Donato: Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis. in Blood 2011
When HEK293T cells were co-transfected with IQGAP1 and VCP (show vcp Antibodies), an immunoprecipitation assay revealed that binding of IQGAP1 with disease-related mutant (R155H or A232E) VCP (show vcp Antibodies) was markedly reduced compared to wild-type VCP (show vcp Antibodies). This suggests that reduction of IQGAP1 and VCP (show vcp Antibodies) interaction may be associated with the pathophysiology of inclusion body myopathy with Paget's disease of bone and frontotemporal dementia (IBMPFD (show vcp Antibodies)).
the results show that IQGAP1 is a novel regulator of type I IFN production, possibly via interacting with NLRC3 (show NLRC3 Antibodies) in human monocytic and epithelial cells
The structural basis for Cdc42 (show CDC42 Antibodies)-induced dimerization of IQGAP1 and IQGAP2 (show IQGAP2 Antibodies) has been uncovered.
The LGR5 primarily functions via the IQGAP1-Rac1 pathway to strengthen cell-cell adhesion in normal adult crypt stem cells and colon cancer cells.
findings suggest a novel role of IQGAP1 in insulin (show INS Antibodies)-regulated interaction between caveolae and cytoskeletal elements of the adipocyte, and that this is quelled in the diabetic state
Alterated IQGAP1/Rho GTPase (show RACGAP1 Antibodies) signaling in myeloproliferative neoplasm erythrocytes is dependent on JAK2 (show JAK2 Antibodies)/CALR (show CALR Antibodies) mutational status.
our data suggest that IQ-domain GTPase-activating protein (show RASA1 Antibodies) 1 may promote the malignant phenotype of invasive ductal carcinoma via canonical Wnt (show WNT2 Antibodies) signaling, and it could be used as a potential prognostic biomarker for breast cancer patients.
IQ domain of IQGAP1 is both necessary and sufficient for binding to ERK1 (show MAPK3 Antibodies) and ERK2 (show MAPK1 Antibodies), as well as to the MAPK (show MAPK1 Antibodies) kinases MEK1 (show MAP2K1 Antibodies) and MEK2 (show MAP2K2 Antibodies).
Data indicate that the IQGAP1 N-terminal fragment spanning residues 1-191 (CHDF) binds to both F-actin and Ca(2 (show CA2 Antibodies)+)/calmodulin (show CALM1 Antibodies).
These data were confirmed by phosphomimetic mutation of serine 1443 to glutamate within RGCT, which led to a significant reduction of IQGAP1 affinity for CDC42 and RAC1, clearly disclosing the critical role of RGCT for these interactions.
Data highlight a unique mechanism of formin (show FMN1 Antibodies) action in which mDia1 and INF2 (show INF2 Antibodies) function in series to stabilize MTs (show NEU2 Antibodies) and point to IQGAP1 as a scaffold that facilitates the activation of one formin (show FMN1 Antibodies) by another.
Hectd1 (show HECTD1 Antibodies) regulates the protein level of IQGAP1 through ubiquitination.
Loss of IQGAP1 results in impaired insulin (show INS Antibodies) signaling and glucose homeostasis in vivo.
These data reveal that IQGAP1 binds to YAP (show YAP1 Antibodies) and modulates its co-transcriptional function, suggesting that IQGAP1 participates in Hippo signaling.
IQGAP1 has a strong signaling relationship with Ras genes in induction of cancer and it is considered as a key gene for induction or suppression of the hepatocellular carcinoma.
IQGAP1 has the potential to modulate airway contraction severity in acute asthma.
we propose that IQGAP1 acts as a small GTPase (show RACGAP1 Antibodies) scaffolding platform within the small GTPase (show RACGAP1 Antibodies) network, and recruits and/or regulates small GTPases, small GTPase (show RACGAP1 Antibodies) regulators and effectors to orchestrate cell behavior
This finding has new implications for involvement of IQGAP1 in cell polarization and migration events and potentially in cell cycle-associated nuclear envelope assembly/disassembly.
IQGAP1 contributes to AngII-induced apoptosis of podocytes by interacting with the ERK1/2 (show MAPK1/3 Antibodies) signaling protein
RSPO (show RSPO1 Antibodies)-LGR4 (show LGR4 Antibodies) not only induces the clearance of RNF43 (show RNF43 Antibodies)/ZNRF3 (show ZNRF3 Antibodies) to increase Wnt receptor levels but also recruits IQGAP1 into the Wnt (show WNT2 Antibodies) signaling complex.
This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.
RasGAP-like with IQ motifs
, ras GTPase-activating-like protein IQGAP1
, Cdc42-Rac1 effector protein