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anti-Human CDC42 Antibodies:
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CDC42 loss suppresses acute myeloid leukemia (show BCL11A Antibodies) cell polarity and division asymmetry.
CDC42 is involved in the trafficking of FGF receptors to the cell membrane to regulate epicardium formation.
LRCH1 (show LRCH1 Antibodies) as a novel effector to restrain PKCalpha (show PKCa Antibodies)-DOCK8 (show DOCK8 Antibodies)-Cdc42 module-induced T cell migration and ameliorate experimental autoimmune encephalomyelitis (EAE).
analysis of phenotypes of Cdc42 and Myo10 (show MYO10 Antibodies) deletion that show multiple roles of filopodial dynamics
Finally, we demonstrate that Cdc42 is involved in neuroligin-dependent presynaptic differentiation of proprioceptive sensory neurons in vitro These data suggest that Cdc42 in presynaptic sensory neurons is essential for proper synapse formation in the development of monosynaptic sensory-motor circuits.
found that DOCK8 associated with LRAP35a, an adaptor molecule that binds to the Cdc42 effector myotonic dystrophy kinase-related Cdc42-binding kinase, and facilitated its activity to phosphorylate myosin II regulatory light chain
These results indicate that HuR (show ELAVL1 Antibodies) promotes early intestinal mucosal repair after injury by increasing Cdc42 translation.
Lrrk1 deficiency in osteoclasts resulted in reduced phosphorylation and activation of RAC1/Cdc42
Akt3 (show AKT3 Antibodies) constitutively suppresses macropinocytosis in macrophages through a novel WNK1 (show WNK1 Antibodies)/SGK1 (show SGK1 Antibodies)/Cdc42 pathway.
Cdc42 is essential for cardiomyocyte proliferation, sarcomere organization and cell-cell adhesion during heart development.
Study Cdc42 regulates Cdc42EP3 (show CDC42EP3 Antibodies) function in cancer-associated fibroblasts.
The structural basis for Cdc42-induced dimerization of IQGAP1 (show IQGAP1 Antibodies) and IQGAP2 (show IQGAP2 Antibodies) has been uncovered.
Polarity signaling via CDC42/atypical protein kinase C (show PRKCZ Antibodies) can affect the dynamic turnover of the intermediate filament network to promote the polarization of the network itself.
Circular RNA ccHIAT1 functions as a metastatic inhibitor to suppress AR-enhanced ccRCC cell migration and invasion via miR (show MLXIP Antibodies)-195-5p/29a-3p/29c-3p/CDC42 signaling pathway.
CDC42 plays an important role in promoting pancreatic cancer development and might serve as a prognostic indicator of pancreatic cancer.
These findings suggest that ACK adopts a dock and coalesce binding mechanism with Cdc42. In contrast to other CRIB-family effectors and indeed other intrinsically disordered proteins, hydrophobic residues likely drive Cdc42-ACK binding.
rapamycin inhibits the RhoA (show RHOA Antibodies), Rac1, and Cdc42 activated by high glucose(HG). Thus, rapamycin shows an obvious protective effect on HG-induced Epithelial-mesenchymal transition, by inhibiting the activation of Rho GTPases (RhoA (show RHOA Antibodies), Rac1, and Cdc42).
These data were confirmed by phosphomimetic mutation of serine 1443 to glutamate within RGCT, which led to a significant reduction of IQGAP1 affinity for CDC42 and RAC1, clearly disclosing the critical role of RGCT for these interactions.
The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20.
cell division cycle 42
, Rho family small GTP binding protein cdc42
, G25K GTP-binding protein
, cell division control protein 42 homolog
, cell division cycle 42 homolog
, GTP binding protein, 25kDa
, GTP-binding protein, 25kD
, dJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))
, dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))
, growth-regulating protein
, small GTP binding protein CDC42