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results demonstrate that Sphingosine 1-phosphate lyase (SPL (show SGPL1 Proteins)) is a host factor that augments type I IFN responses during influenza A virus infection; study delineates the relationship between IKKepsilon and SPL (show SGPL1 Proteins), which provides a mechanistic understanding of the pro-IFN activity of SPL (show SGPL1 Proteins)
Virus-activated kinase IKKepsilon phosphorylated YAP (show YAP1 Proteins) at Ser403 and thereby triggered degradation of YAP (show YAP1 Proteins) in lysosomes and, consequently, relief of YAP (show YAP1 Proteins)-mediated inhibition of the cellular antiviral response.
We then determined that YAP1 (show YAP1 Proteins) negatively regulates miR (show MLXIP Proteins)-let-7b/i by overexpressing and silencing YAP1 (show YAP1 Proteins) expression. In addition, miR (show MLXIP Proteins)-let-7b/i feedback decreases the expression of IKBKE and YAP1 (show YAP1 Proteins) and suppresses the transportation of YAP1 (show YAP1 Proteins) located in the nucleus. Therefore, the regulatory feedback circuit of IKBKE upward arrow-->YAP1 (show YAP1 Proteins) upward arrow-->miR (show MLXIP Proteins)-let-7b/i downward arrow-->IKBKE upward arrow dictates glioblastoma progress...
our findings highlight the functional importance of IKBKE in pancreatic cancer
we define a pathobiologic function for IKKepsilon in reprogramming glucose metabolism and driving progression in pancreatic ductal adenocarcinoma
demonstrate a key role of TBK1 (show TBK1 Proteins)/IKKepsilon in the survival and proliferation of HTLV-1-transformed T cells
Data suggest that changes in inhibitor of nuclear factor kappa B kinase subunit epsilon (IKKepsilon) and TANK-binding kinase 1 (TBK1 (show TBK1 Proteins)) expression may be involved in the development of intestinal-type gastric cancer.
Live NiV infection, but not a recombinant NiV lacking the M protein, reduced the levels of endogenous TRIM6 (show TRIM6 Proteins) protein expression. To our knowledge, matrix proteins of paramyxoviruses have never been reported to be involved in innate immune antagonism. We report here a novel mechanism of viral innate immune evasion by targeting TRIM6 (show TRIM6 Proteins), IKKepsilon and unanchored polyubiquitin (show UBB Proteins) chains.
The adaptor molecule RAIDD (show CRADD Proteins) coordinates IKKepsilon and IRF7 (show IRF7 Proteins) interaction to ensure efficient expression of type I interferon (show IFNA Proteins).
These findings collectively support the conclusion that IKK (show CHUK Proteins) modulates innate immune signaling cascades via phosphorylating the RIG-I (show DDX58 Proteins) cytosolic sensor, providing a feedback regulatory mechanism.
REGgamma-mediated control of IkappaBvarepsilon contributes to NFkappaB activation and promotes bowel inflammation and associated tumour formation in response to chronic injury
Suggest that by reducing production of cAMP in adipocytes, PDE3B, IKKepsilon and TBK1 (show TBK1 Proteins) may contribute to the repression of energy expenditure during obesity.
A role for APPL1 (show APPL1 Proteins) in TLR3 (show TLR3 Proteins)/4-dependent TBK1 (show TBK1 Proteins) and IKKepsilon activation in macrophages.
The results highlight the importance of the C-terminal region in the functional activity of IKKepsilon in innate immune response
tic (show ARNTL Proteins) ablation of IKBKE resulted in enhanced and prolonged priming of the NLRP3 (show NLRP3 Proteins) inflammasome in cultured macrophages, in hypertrophic adipose tissue, and in livers of hypercholesterolemic mice.
novel insight into IKKepsilon, which is involved in adipose tissue inflammation during the development of obesity
miR (show MLXIP Proteins)-339-5p inhibits expression of the pro-inflammatory factors in alcohol-induced brain inflammation through the NF-kappaB (show NFKB1 Proteins) pathway by abolishing IKK-beta (show IKBKB Proteins) and IKK-epsilon activity.
IKKepsilon deficiency inhibits inflammation and induces cardiac protection in high-fat diet-induced obesity in mice.
IKKepsilon is expressed in neurons and is upregulated in the hypothalamus of obese mice, contributing to insulin (show INS Proteins) and leptin (show LEP Proteins) resistance.
IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
, inhibitor of nuclear factor kappa-B kinase subunit epsilon
, inhibitor of nuclear factor kappa-B kinase subunit epsilon-like
, I-kappa-B kinase epsilon
, IKK-related kinase epsilon
, inducible I kappa-B kinase
, inducible IkappaB kinase
, inhibitor of kappaB kinase epsilon
, inducible IKappaB kinase