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Browse our Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon Proteins (IKBKE)

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Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon Proteins (IKBKE)
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Synonyms:
AW558201, IKBKE, IKK-E, IKK-i, IKKE, IKKepsilon, Ikki, MGC130907, zgc:100844
list all proteins Gene Name GeneID UniProt
IKBKE 9641 Q14164
Rat IKBKE IKBKE 363984  
IKBKE 56489 Q9R0T8

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More Proteins for Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon Interaction Partners

Human Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) interaction partners

  1. These findings collectively support the conclusion that IKK (show CHUK Proteins) modulates innate immune signaling cascades via phosphorylating the RIG-I (show DDX58 Proteins) cytosolic sensor, providing a feedback regulatory mechanism.

  2. Blunting of NOX2 (show CYBB Proteins)-dependent IKKepsilon oncogenic kinase expression reduces proliferation and viability of human breast cancer cells.

  3. The P proteins from the rabies virus street strains 1088 and HCM-9 significantly inhibited I-kappa B kinase (IKK (show CHUK Proteins))-inducible IRF-3 (show IRF3 Proteins)-dependent IFN-beta (show IFNB1 Proteins) promoter activity.

  4. IKBKE Upregulation is Positively Associated with Squamous Cell Carcinoma of the Lung In Vivo and Malignant Transformation of Human Bronchial Epithelial Cells In Vitro.

  5. DC-SIGN (show CD209 Proteins) directs adaptive T helper cell type-2immunity to fucose-expressing pathogens via an IKKepsilon-CYLD (show CYLD Proteins)-dependent signalling pathway leading to Bcl3 (show BCL3 Proteins) activation.

  6. these findings reveal that IKBKE-associated cytokine signaling promotes tumorigenicity of immune-driven TNBC and identify a potential therapeutic strategy using clinically available compounds.

  7. A role for APPL1 (show APPL1 Proteins) in TLR3 (show TLR3 Proteins)/4-dependent TBK1 (show TBK1 Proteins) and IKKepsilon activation in macrophages.

  8. The results highlight the importance of the C-terminal region in the functional activity of IKKepsilon in innate immune response.Interestingly, corresponding region and residues are not required for activation of downstream signaling by TBK1.

  9. The above-mentioned data suggest that let-7b/i inhibit the invasive ability of glioma cells by directly downregulating IKBKE and indirectly upregulating E-cadherin (show CDH1 Proteins).

  10. IKB (show ARNTL Proteins)KE is a novel regulator that limits chronic inflammation during metabolic (show NLRP3 Proteins)disease and atherosclerosis. The pathogenic relevance of IKBKE was indicated by the colocalization with macrophages in tissues and in atherosclerotic plaques.

Mouse (Murine) Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) interaction partners

  1. REGgamma-mediated control of IkappaBvarepsilon contributes to NFkappaB activation and promotes bowel inflammation and associated tumour formation in response to chronic injury

  2. Suggest that by reducing production of cAMP in adipocytes, PDE3B, IKKepsilon and TBK1 (show TBK1 Proteins) may contribute to the repression of energy expenditure during obesity.

  3. A role for APPL1 (show APPL1 Proteins) in TLR3 (show TLR3 Proteins)/4-dependent TBK1 (show TBK1 Proteins) and IKKepsilon activation in macrophages.

  4. The results highlight the importance of the C-terminal region in the functional activity of IKKepsilon in innate immune response

  5. tic (show ARNTL Proteins) ablation of IKBKE resulted in enhanced and prolonged priming of the NLRP3 (show NLRP3 Proteins) inflammasome in cultured macrophages, in hypertrophic adipose tissue, and in livers of hypercholesterolemic mice.

  6. novel insight into IKKepsilon, which is involved in adipose tissue inflammation during the development of obesity

  7. miR (show MLXIP Proteins)-339-5p inhibits expression of the pro-inflammatory factors in alcohol-induced brain inflammation through the NF-kappaB (show NFKB1 Proteins) pathway by abolishing IKK-beta (show IKBKB Proteins) and IKK-epsilon activity.

  8. IKKepsilon deficiency inhibits inflammation and induces cardiac protection in high-fat diet-induced obesity in mice.

  9. IKKepsilon is expressed in neurons and is upregulated in the hypothalamus of obese mice, contributing to insulin (show INS Proteins) and leptin (show LEP Proteins) resistance.

  10. Data indicate the role for immune-response functions of IkappaBepsilon in B cells; it regulates proliferative capacity via at least two mechanisms involving cRel- and RelA (show NFkBP65 Proteins)-containing NF-kappaB (show NFKB1 Proteins) dimers.

Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE) Protein Profile

Protein Summary

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009

Alternative names and synonyms associated with Inhibitor of kappa Light Polypeptide Gene Enhancer in B-Cells, Kinase epsilon (IKBKE)

  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (IKBKE)
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (ikbke)
  • inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon (Ikbke)
  • inhibitor of kappaB kinase epsilon (Ikbke)
  • AW558201 protein
  • IKBKE protein
  • IKK-E protein
  • IKK-i protein
  • IKKE protein
  • IKKepsilon protein
  • Ikki protein
  • MGC130907 protein
  • zgc:100844 protein

Protein level used designations for IKBKE

inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon , IKKe , inhibitor of nuclear factor kappa-B kinase subunit epsilon , inhibitor of nuclear factor kappa-B kinase subunit epsilon-like , I-kappa-B kinase epsilon , IKK-epsilon , IKK-related kinase epsilon , inducible I kappa-B kinase , inducible IkappaB kinase , inhibitor of kappaB kinase epsilon , IKK-E , inducible IKappaB kinase

GENE ID SPECIES
430480 Gallus gallus
437024 Danio rerio
478950 Canis lupus familiaris
695607 Macaca mulatta
734896 Xenopus laevis
742813 Pan troglodytes
100019578 Monodelphis domestica
100055384 Equus caballus
100077063 Ornithorhynchus anatinus
100448480 Pongo abelii
100519508 Sus scrofa
100548215 Meleagris gallopavo
100562496 Anolis carolinensis
9641 Homo sapiens
533216 Bos taurus
363984 Rattus norvegicus
56489 Mus musculus
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