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anti-Human FZD2 Antibodies:
anti-Rat (Rattus) FZD2 Antibodies:
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Human Polyclonal FZD2 Primary Antibody for IHC (p), IHC - ABIN451680
Oishi, Kawakami, Raya, Callol-Massot, Izpisúa Belmonte: Regulation of primary cilia formation and left-right patterning in zebrafish by a noncanonical Wnt signaling mediator, duboraya. in Nature genetics 2006
Show all 2 Pubmed References
Human Polyclonal FZD2 Primary Antibody for IHC, ELISA - ABIN302136
Hirano, Yonezawa, Yunoue, Habu, Uchida, Yoshioka, Kishida, Kishida, Oyoshi, Fujio, Sugata, Yamahata, Hanaya, Arita: Immunoreactivity of Wnt5a, Fzd2, Fzd6, and Ryk in glioblastoma: evaluative methodology for DAB chromogenic immunostaining. in Brain tumor pathology 2014
Cow (Bovine) Polyclonal FZD2 Primary Antibody for WB - ABIN2776701
Li, Chen, Hu, Xing, Sasaki, Villosis, Li, Nishita, Minami, Minoo: Ror2 modulates the canonical Wnt signaling in lung epithelial cells through cooperation with Fzd2. in BMC molecular biology 2008
Maturation of a central brain flight circuit in Drosophila requires Fz2 and Ca2 (show CA2 Antibodies)+ signaling.
The heterotrimeric G protein Go functions as a transducer of Wingless-Frizzled 2 signaling in the synapse and Ankyrin 2 (show ANK2 Antibodies) as a target of Go signaling required for neuromuscular junction formation
Study finds that C-terminal fragments of the Wg receptor DFz2 accumulate in nuclear foci in association with large RNA granules localizing to the space between the inner & and outer nuclear membranes; granules are found at of inner membrane invaginations, are bounded by LamC, and can be seen leaving the nucleus.
Knockdown of Tc-fz1 (show FZD4 Antibodies) alone interfered with the formation of the proximo-distal and the dorso-ventral axes during leg development, whereas no effect was observed with single Tc-fz2 or Tc-fz4 (show FZD4 Antibodies) RNAi knockdowns.
Wnt-activated growth of the postsynaptic membrane is mediated by the synapse-to-nucleus translocation and active nuclear import of Fz2-C via a selective Importin-beta11/alpha2 pathway.
subcellular Fz localization, through the association with other membrane proteins, is a critical aspect in regulating the signaling specificity within the Wnt (show WNT4 Antibodies)/Fz signaling pathways
Frizzled2 achieves ligand capture and internalization, whereas Arrow, and perhaps downstream signalling, are essential for lysosomal targeting.
concluded that, at synapses, Wingless signal transduction occurs through the nuclear localization of DFrizzled2-C for potential transcriptional regulation of synapse development
DFz2 functions as an endocytic receptor for Wingless in the Drosophila wing
Data show that GRIP is necessary for the trafficking of Frizzled-2 to the nucleus.
fzd2 are broadly expressed throughout the head, during zebrafish craniofacial development
frizzled 8c is a receptor for wnt8 (show WNT8A Antibodies)
conserved role of a Wnt5 (show WNT5A Antibodies)/Fz2 signaling pathway in islet formation during pancreatic development.
Treatment of the cell lines with Fzd2 siRNA resulted in significantly reduced migration and invasiveness but did not affect proliferation.Patients with high Fzd2 expression had significantly poorer recurrencefree survival than those with low expression
Fzd2 did not influence the proliferation of EC cells.
FZD2 was downregulated in an adenoid cystic carcinoma cell line with high metastatic potential, vs another with low potential. Knockdown of FZD2 downregulated the expression of PAI-1 (show SERPINE1 Antibodies).
Sonazoid enhanced sonoporation of the cells with the diagnostic US device and the suppression of proliferation of both HCC (show FAM126A Antibodies) cell lines by shRNA-Fz2.
the present study demonstrated that Fzd2 contributes to the migration and invasion of OSCC cells, at least partly through regulation of the STAT3 (show STAT3 Antibodies) pathway
CD82 (show CD82 Antibodies) enhanced the expression of miR (show MLXIP Antibodies)-203 and directly downregulated FZD2 expression, suppressing cancer metastasis/cell migration by inhibiting the Wnt (show WNT2 Antibodies) signaling pathway.
the FRIZZLED2 mutation is a de novo, novel cause for autosomal dominant omodysplasia.
Fz2 was positive in both the cell membrane and cytoplasm of gastric cancer tissues of moderately differentiated and poorly differentiated adenocarcinoma.Fz2 expression pattern in normal stomach tissues.
Pharmacologic and genetic perturbations reveal that Fzd2 drives epithelial-mesenchymal transition and cell migration through a previously unrecognized, noncanonical pathway that includes Fyn (show FYN Antibodies) and Stat3 (show STAT3 Antibodies).
Data suggest that an anti-Wnt5a antibody was capable of suppressing Wnt5a-dependent internalization of Fz2 receptor, resulting in the prevention of metastasis of gastric cancer cells by inhibiting the activation of Rac1 and the expression of laminin gamma2.
the Wnt5a (show WNT5A Antibodies)/Frizzled-2 axis suppresses beta-catenin (show CTNNB1 Antibodies) signaling in hepatocytes in an autocrine manner, thereby contributing to timely conclusion of the liver regeneration process
Fzd2 promotes changes in epithelial cell length and shape. These changes in cell morphology deform the developing lung epithelial tube to generate and maintain new domain branches.
Results provide further insight into the role of Wnt5a (show WNT5A Antibodies) and Fzd2 in the pathogenesis of adult amyotrophic lateral sclerosis transgenic mice.
observed genetic interactions between Fz2 and Fz7 (show FZD7 Antibodies) and five canonical and/or non-canonical signaling molecules: Dvl3 (show DVL3 Antibodies), Wnt3a (show WNT3A Antibodies), Wnt11 (show WNT11 Antibodies), Vangl2 (show VANGL2 Antibodies), and Wnt5a (show WNT5A Antibodies).
Frizzled signaling is involved in diverse tissue closure processes, defects in which account for some of the most common congenital anomalies.
Indicate that myofibroblast migration and differentiation are modulated via Wnt (show WNT2 Antibodies)/Fzd signalling.
Protein kinase (show CDK7 Antibodies) G is a critical downstream effector of the noncanonical Wnt (show WNT2 Antibodies)-Frizzled-2/cGMP/Ca2 (show CA2 Antibodies)+ pathway
Preferential expression of Frizzled2 gene is detected in fetal liver kinase (Flk)1 (show KDR Antibodies)-negative and Flk1 (show KDR Antibodies)-positive cells under different culture conditions.
This intronless gene is a member of the frizzled gene family. Members of this family encode seven-transmembrane domain proteins that are receptors for the wingless type MMTV integration site family of signaling proteins. This gene encodes a protein that is coupled to the beta-catenin canonical signaling pathway. Competition between the wingless-type MMTV integration site family, member 3A and wingless-type MMTV integration site family, member 5A gene products for binding of this protein is thought to regulate the beta-catenin-dependent and -independent pathways.
, drosophila frizzled 2
, frizzled homolog 8
, frizzled homolog 2 (Drosophila)
, frizzled 2
, frizzled 2, seven transmembrane spanning receptor
, frizzled homolog 2
, Drosophila polarity gene (frizzled) homologue
, Drosophila polarity gene homolog 2