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The protein encoded by AFF4 belongs to the AF4 family of transcription factors involved in leukemia.
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The TAR (show RBM8A Proteins) central loop contacts the CycT1 (show CCNT1 Proteins) Tat (show TAT Proteins)-TAR (show RBM8A Proteins) recognition motif (TRM) and the second Tat (show TAT Proteins) Zn(2+)-binding loop. Hydrogen-deuterium exchange (HDX) shows that AFF4 helix 2 is stabilized in the TAR (show RBM8A Proteins) complex despite not touching the RNA, explaining how it enhances TAR (show RBM8A Proteins) binding to the SEC 50-fold.
AFF4 is positioned to make unexpected direct contacts with HIV Tat (show TAT Proteins), and Tat (show TAT Proteins) enhances P-TEFb (show CCNT1 Proteins)/CCNT1 (show CCNT1 Proteins) affinity for AFF4.
missense mutations in AFF4 in three unrelated probands with a new syndrome that phenotypically overlaps Cornelia de Lange syndrome (CdLS (show NIPBL Proteins)) that was named CHOPS syndrome (C for cognitive impairment and coarse facies, H for heart defects, O for obesity, P for pulmonary involvement and S for short stature and skeletal dysplasia)
HIV-1 Tat (show TAT Proteins) recruits transcription elongation factors dispersed along a flexible AFF4 scaffold.
overexpression of AFF2 (show AFF2 Proteins)/3/4 interferes with the organization and/or biogenesis of nuclear speckles.
Through the bridging functions of Tat (show TAT Proteins) and AFF4, P-TEFb (show CCNT1 Proteins) and ELL2 (show ELL2 Proteins) combine to form a bifunctional elongation complex that greatly activates HIV-1 transcription.
AFF4 is required for super elongation complex stability and proper transcription by poised RNA polymerase II.
MCEF has 21 exons & 7 nuclear localization sequence. 3 protein sequences, coded by 3 exons, mediate nuclear localization. Ectopic expression of MCEF repressed HIV-1 LTR-directed RNA polymerase II transcription, at the level of Tat (show TAT Proteins)-transactivation.
Data describe the cloning and expression of MCEF, a member of the AF4 family of transcription factors involved in acute lymphoblastic leukemia. [MCEF]
define a specific pairing of two amino acids that creates a salt bridge between MLLT1 (show MLLT1 Proteins)/3 and AFF proteins that is critically important for MLL (show MLL Proteins)-mediated transformation of HPCs
AFF4 may therefore help to maintain activation of AMPK (show PRKAA1 Proteins) downstream signaling under conditions of prolonged stimulation with ghrelin (show GHRL Proteins), such as during fasting.
AF5q31 (Aff4) is a transcriptional regulator in testicular somatic cells and is essential for male germ cell differentiation and survival.
Af4 functions as a positive regulator of Pol II transcription elongation factor b (P-TEFb) kinase and, in complex with MLL fusion partners Af9, Enl and Af10, as a mediator of histone H3-K79 methylation by recruiting Dot1 to elongating Pol II
In the absence of Runx1 (show RUNX1 Proteins) on the silencer, P-TEFb (show CCNT1 Proteins) interacts with the transcription complex, forming a different chromatin loop between the enhancer and the promoter, which leads to the expression of the CD4 (show CD4 Proteins) gene
The protein encoded by this gene belongs to the AF4 family of transcription factors involved in leukemia. It is a component of the positive transcription elongation factor b (P-TEFb) complex. A chromosomal translocation involving this gene and MLL gene on chromosome 11 is found in infant acute lymphoblastic leukemia with ins(5\;11)(q31\;q31q23).
AF4/FMR2 family, member 4
, ALL1 fused gene from 5q31
, AF4/FMR2 family member 4-like
, AF4/FMR2 family member 4
, ALL1-fused gene from chromosome 5q31 protein
, major CDK9 elongation factor-associated protein