Activin Receptor Type I Proteins (ACRV1)

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Additionally we are shipping Activin Receptor Type I Antibodies (179) and Activin Receptor Type I Kits (16) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
ACRV1 90 Q04771
ACRV1 79558 P80201
ACRV1 11477 P37172
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Top Activin Receptor Type I Proteins at antibodies-online.com

Showing 10 out of 35 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Human Cells Human Fc Tag,His tag 100 μg Log in to see 14 to 16 Days
$250.80
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Human Cells Mouse Fc Tag,His tag 100 μg Log in to see 14 to 16 Days
$250.80
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Baculovirus infected Insect Cells Human His tag 100 μg Log in to see 14 to 16 Days
$272.80
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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
$5,355.45
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
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Human Cells Dog His tag 100 μg Log in to see 14 to 16 Days
$250.80
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Human Cells Rat Fc Tag 100 μg Log in to see 14 to 16 Days
$250.80
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Human Cells Cynomolgus Fc Tag 100 μg Log in to see 14 to 16 Days
$250.80
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Escherichia coli (E. coli) Human His tag,GST tag 100 μg Log in to see 15 to 18 Days
$608.00
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HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$814.00
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ACRV1 Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , , , ,
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Rat (Rattus) ,
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Mouse (Murine) , ,
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More Proteins for Activin Receptor Type I (ACRV1) Interaction Partners

Human Activin Receptor Type I (ACRV1) interaction partners

  1. Results showed that ACVR1 was a direct target of miR (show MLXIP Proteins)-384 and was involved in the inhibitory effects of miR (show MLXIP Proteins)-384 on breast cancer progression. Furthermore, the study indicated that ACVR1 activated the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) signaling pathway in breast cancer.

  2. Study emphasizes about the role of ACVR1 which encoding a receptor for BMP proteins in fibrodysplasia ossificans progressiva (FOP). Most FOP patients carry the recurrent R206H substitution in the GS domain, whereas a few other mutations are responsible for limited cases. Mutations cause a dysregulation of the downstream BMP-dependent pathway making mutated ACVR1 responsive to a non-canonical ligand, Activin A (show INHBA Proteins). [review]

  3. The role of an ALK2 mutation (R258S) in IRIDA (show TMPRSS6 Proteins) development in a patient also bearing compound heterozygous mutations in TMPRSS6 (show TMPRSS6 Proteins) was demonstrated by reconstructing in vitro the proband's genotype, expressing mutants TMPRSS6 (show TMPRSS6 Proteins) and ACVR1 in the presence of hemojuvelin (show HFE2 Proteins) and assessing hepcidin (show HAMP Proteins) activation. ALK2(R258S) maintained high hepcidin (show HAMP Proteins) expression in the presence of MT2 (show MT2 Proteins)(I212T).

  4. activation of AMPK (show PRKAA1 Proteins) upregulated Smad6 (show SMAD6 Proteins) and Smurf1 (show SMURF1 Proteins) and thereby enhanced their interactions, resulting in its proteosome-dependent degradation of ALK2.

  5. the Fibrodysplasia Ossificans Progressiva mutation ACVR1(R206H) is more sensitive to a number of natural ligands.

  6. both bone morphogenetic protein 2 (BMP2 (show BMP2 Proteins)) and BMP6 (show BMP6 Proteins) are proangiogenic in vitro and ex vivo and that the BMP type I receptors, activin receptor-like kinase 3 (ALK3 (show BMPR1A Proteins)) and ALK2, play crucial and distinct roles in this process.

  7. Fibrodysplasia ossificans progressiva (FOP) syndrome is caused by mutation of the gene ACVR1. Developed is a simplified one-step procedure by simultaneously introducing reprogramming and gene-editing components into human fibroblasts derived from patient with FOP. The one-step-mediated ALK2 gene-corrected induced pluripotent stem cells restored global gene expression pattern.

  8. The ACVR1 R206H mutation may not directly increase the formation of mature chondrogenic or osteogenic cells.

  9. Authors demonstrated that the BMP type I receptor ALK-2 (encoded by the ACVR1 gene) has crucial roles in apoptosis induction of patient-derived glioma-initiating cells (GICs), TGS (show LIN9 Proteins)-01 and TGS (show LIN9 Proteins)-04.

  10. Data suggest BMP9/GDF2 (show GDF2 Proteins) and BMP10 (show BMP10 Proteins) synergize with TNFA (show TNF Proteins) to increase monocyte recruitment to vascular endothelial cells; process appears to be mediated mainly via ALK2/ACVR1 (which exhibits protein kinase (show CDK7 Proteins) activity). These studies used in vitro flow monocyte adhesion assay. (BMP9 (show GDF2 Proteins) = growth differentiation factor 2 (show GDF2 Proteins); BMP10 (show BMP10 Proteins) = bone morphogenetic protein 10 (show BMP10 Proteins); TNFA (show TNF Proteins) = tumor necrosis factor alpha (show TNF Proteins); ALK2/ACVR1 = activin A receptor type 1)

Mouse (Murine) Activin Receptor Type I (ACRV1) interaction partners

  1. findings demonstrate that hair follicle specific ALK2 is intricately involved in maintenance of the stem cell niche and wound healing

  2. NODAL/Activin signaling induces dramatic chromatin landscape changes, and a dynamic transcriptional network regulated by SMAD2 (show SMAD2 Proteins), acting via multiple mechanisms.

  3. Acute tacrolimus treatment transiently increases hepcidin (show HAMP Proteins) in wild-type mice. FKBP12 (show FKBP1A Proteins) preferentially targets the BMP receptor (show BMPR1A Proteins) ALK2. ALK2 mutants defective in binding FKBP12 (show FKBP1A Proteins) increase hepcidin (show HAMP Proteins) expression in a ligand-independent manner, through BMP-SMAD (show SMAD1 Proteins) signaling.

  4. The authors demonstrated that ubiquitin-specific protease (USP) 4 (show USP4 Proteins) strongly induces activin/BMP signaling by removing the inhibitory monoubiquitination from SMAD4 (show SMAD4 Proteins).

  5. Enhanced SMAD (show SMAD1 Proteins)-dependent BMP signaling through constitutively active ACVR1 in palatal epithelium causes submucous cleft palate in mice, via medial-edge-epithelium persistence presumably due to the up regulation of DeltaNp63 andresultingreductionofcaspase-3 activation. 2.

  6. BMP signaling mediated by coordination of ALK2/ACVR1, ALK3/BMPR1A (show BMPR1A Proteins), and BMPR2 (show BMPR2 Proteins) is an essential proangiogenic cue for retinal vessels.

  7. This study showed that Gja1 (show GJA1 Proteins) may act downstream of cAMP-PKA signal to mediate the effects of Acvr1 on the differentiation of uterine stromal cells through targeting Hand2 (show HAND2 Proteins).

  8. Results showed activin-C and follistatin are differentially expressed during prostate development and suggested that the antagonistic property of follistatin is secondary to the action of activin-C. Study provides evidence to support a role of activin-C in prostate development and provides new insights in the spatiotemporal localization of activins and their antagonists during mouse prostate development.

  9. BMPR1B plays distinct roles from BMPR1A and ACVR1 in maintaining bone mass and transducing BMP signaling

  10. Suggest that BMP signaling upregulates the calcineurin/nuclear factor of activated T cell (show NFATC3 Proteins) pathway via BMP type I receptor ALK2, contributing to cardiac hypertrophy and fibrosis.

Horse (Equine) Activin Receptor Type I (ACRV1) interaction partners

  1. Data suggest that ACVR1 mRNA and protein are present in granulosa cells of ovarian follicles at mid-estrous and pre-ovulatory stages; ACVR1 mRNA and protein are also present in exosomes isolated from mid-estrous and preovulatory follicles.

Activin Receptor Type I (ACRV1) Protein Profile

Protein Summary

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling\; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.

Gene names and symbols associated with ACRV1

  • activin A receptor type 1 (ACVR1)
  • activin A receptor type 1 (Acvr1)
  • activin A receptor, type 1 (Acvr1)
  • activin A receptor type 1 S homeolog (acvr1.S)
  • ActR-I protein
  • ActR-IA protein
  • actri protein
  • ActRIA protein
  • Acvr protein
  • acvr1 protein
  • acvr1-a protein
  • acvr1-b protein
  • acvr1a protein
  • acvrlk2 protein
  • alk-2 protein
  • alk2 protein
  • alk8 protein
  • D330013D15Rik protein
  • fop protein
  • sax protein
  • skr1 protein
  • Tsk7L protein
  • tsri protein
  • xALK-2 protein

Protein level used designations for ACRV1

TGF-B superfamily receptor type I , activin A receptor, type II-like kinase 2 , activin receptor type I , activin receptor type-1 , activin receptor-like kinase 2 , hydroxyalkyl-protein kinase , serine/threonine-protein kinase receptor R1 , ACTR-I , SKR1 , TSR-I , activin A receptor, type 1 , activin type I receptor , type I TGF B receptor , activin A receptor, type I , activin receptor type IA , TSK-7L , activin A receptor type 1 S homeolog , activin A receptor type I S homeolog , activin receptor like kinase-2

GENE ID SPECIES
90 Homo sapiens
79558 Rattus norvegicus
338068 Bos taurus
395246 Gallus gallus
443161 Ovis aries
11477 Mus musculus
478757 Canis lupus familiaris
100724428 Cavia porcellus
399083 Xenopus laevis
100050899 Equus caballus
697935 Macaca mulatta
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