anti-Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A) Antibodies

Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
Anti-Rat BAZ2A BAZ2A 304601  
BAZ2A 11176 Q9UIF9
Anti-Mouse BAZ2A BAZ2A 116848  
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Top anti-BAZ2A Antibodies at antibodies-online.com

Showing 10 out of 24 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Delivery Price Details
Human Rabbit Un-conjugated ELISA, ICC, IF, WB Western blot analysis of extracts from 293, using BAZ2A Antibody. Lane 1 was treated with the blocking peptide. ABIN6274929 staining  Hela cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25¡ãC. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37¡ãC. An  Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibod 100 μL 11 to 12 Days
$390.77
Details
Human Rabbit Un-conjugated ELISA, WB   100 μg 2 to 3 Days
$302.50
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Human Rabbit Un-conjugated ELISA, WB   100 μL Available
$363.46
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Human Rabbit Un-conjugated ELISA, WB   100 μg 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated ChIP, WB Western Blot analysis of (1) 150 ug nuclear extract of NIH3T3 cells, and (2) 150 ug nuclear extract of HeLa cells. ChIP assays were performed using chromatin from HEK293T and NIH3T3 cells. 100 ug sheared chromatin and either 5 ul of antibody or 5 ul IgG which was used as negative IP control. The figure shows the recovery by the antibody and by IgG, normalised to the input DNA. These results show that, both in HEK293T and in NIH3T3 cells, BAZ2A is associated with the promoter, but not with the coding region of the 28srRNA gene. 100 μL 11 to 12 Days
$637.32
Details
Human Mouse Un-conjugated WB Western Blot analysis of BAZ2A expression in transfected 293T cell line by BAZ2A MaxPab polyclonal antibody.Lane 1: BAZ2A transfected lysate(209.55 KDa).Lane 2: Non-transfected lysate. 50 μg 11 to 12 Days
$440.00
Details
Human Rabbit Biotin ELISA   100 μg 11 to 16 Days
$426.40
Details
Human Rabbit FITC ELISA   100 μg 11 to 16 Days
$426.40
Details
Human Rabbit HRP ELISA   100 μg 11 to 16 Days
$426.40
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Human Rabbit Un-conjugated ELISA, IF/ICC   100 μg 11 to 16 Days
$426.40
Details

More Antibodies against BAZ2A Interaction Partners

Human Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A) interaction partners

  1. the results of the present study demonstrated that TIP5 regulates beta-catenin/TCF7L2 signaling via TIP5 during HCC progression and suggests that TIP5 may be a promising therapeutic target for the treatment of HCC.

  2. Data suggest that binding of helical tail of histone 3 (H3) with PHD ('plant homeodomain') fingers of BAZ2A or BAZ2B (bromodomain adjacent to zinc finger domain 2A or 2B) requires molecular recognition of secondary structure motifs within H3 tail and could represent an additional layer of regulation in epigenetic processes.

  3. Data show that SUMOylated BANP, E5R, and Nac1 (BEN) domain 3 (BEND3) stabilizes NoRC component TTF-1-interacting protein 5 (Tip5)via association with ubiquitin specific protease 21 (USP21) debiquitinase

  4. Crystal structures of PHD zinc finger and bromodomains from human TIP5 and BAZ2B in free form and bound to H3 and/or H4 histones.

  5. The study showed that the NMR structure of the TAM domain of TIP5 resembles the fold of the MBD domain, found in methyl-CpG binding proteins.

  6. association with ribosomal DNA is impaired in embryonic stem cells and occurs upon cell differentiation

  7. BAZ2A is overexpressed in prostate cancer, maintains its cell growth, regulates protein-coding genes, and interacts with EZH2 to silence genes repressed in metastasis. Its overexpression is associated with a CpG island methylator phenotype.

  8. High BAZ2A expression is associated with pancreatic cancer.

  9. Data show that MOF acetylates TIP5, the largest subunit of NoRC, at a single lysine residue, K633, adjacent to the TIP5 RNA-binding domain, and that SIRT1 (removes the acetyl group from K633.

  10. the apparent occurrence of an unusual TG 3' splice site in intron 1 is discussed

Mouse (Murine) Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A) interaction partners

  1. NuRD negatively regulates TIP5 expression, thereby inhibiting ribosomal DNA (rDNA) methylation and maintaining demethylation state of rDNA promoters.

  2. Tip5 not only mediates the establishment of rDNA silencing but also the formation of perinucleolar heterochromatin that contains centric and pericentric repeats.

  3. Overexpression of TIP5, the large subunit of NoRC, mediates deacetylation of nucleosomes near the rDNA promoter. TIP5 associates with HDAC1 in vivo & in vitro. Deletion of the C-terminal PHD finger & bromodomain abolishes the interaction of TIP5 & HDAC1.

  4. The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing.

  5. Mutations that disrupt the stem-loop structure impair binding of TIP5, the large subunit of NoRC, to pRNA and abolish targeting of NoRC to nucleoli.

  6. Data show that MOF acetylates TIP5, the largest subunit of NoRC, at a single lysine residue, K633, adjacent to the TIP5 RNA-binding domain, and that SIRT1 (removes the acetyl group from K633.

BAZ2A Antigen Profile

Protein Summary

Essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys- 16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter\; pRNA- binding is required for heterochromatin formation and rDNA silencing (By similarity).

Gene names and symbols associated with BAZ2A

  • bromodomain adjacent to zinc finger domain, 2A (Baz2a) antibody
  • bromodomain adjacent to zinc finger domain, 2A (baz2a) antibody
  • bromodomain adjacent to zinc finger domain 2A (BAZ2A) antibody
  • bromodomain adjacent to zinc finger domain 2A (baz2a) antibody
  • bromodomain adjacent to zinc finger domain 2A L homeolog (baz2a.L) antibody
  • AA415431 antibody
  • bax2a antibody
  • C030005G16Rik antibody
  • C78388 antibody
  • mKIAA0314 antibody
  • Tip5 antibody
  • Walp3 antibody
  • zgc:101601 antibody

Protein level used designations for BAZ2A

bromodomain adjacent to zinc finger domain protein 2A , bromodomain adjacent to zinc finger domain, 2A , bromodomain adjacent to zinc finger domain protein 2A-like , TTF-I interacting peptide 5 , TTF-I-interacting protein 5 , hWALp3 , transcription termination factor I-interacting protein 5 , Transcription termination factor I-interacting protein 5 , putative chromatin remodelling factor BAZ2A

GENE ID SPECIES
304601 Rattus norvegicus
450079 Danio rerio
452433 Pan troglodytes
481116 Canis lupus familiaris
509799 Bos taurus
713220 Macaca mulatta
100126219 Xenopus (Silurana) tropicalis
100385842 Callithrix jacchus
100457132 Pongo abelii
100473683 Ailuropoda melanoleuca
100582288 Nomascus leucogenys
11176 Homo sapiens
116848 Mus musculus
398712 Xenopus laevis
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