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Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Additionally we are shipping CD33 Antibodies (683) and CD33 Kits (44) and many more products for this protein.
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Human CD33 Protein expressed in HEK-293 Cells - ABIN2713661
Vyas, Schneider, Shatnyeva, Reiners, Tawadros, Kloess, Köhl, Hallek, Hansen, Pogge von Strandmann: Mono- and dual-targeting triplebodies activate natural killer cells and have anti-tumor activity in vitro and in vivo against chronic lymphocytic leukemia. in Oncoimmunology 2016
Human CD33 Protein expressed in HEK-293 Cells - ABIN2713662
Son, Diamond, Volpe, Aranow, Mackay, Santiago-Schwarz: Evidence for C1q-mediated crosslinking of CD33/LAIR-1 inhibitory immunoreceptors and biological control of CD33/LAIR-1 expression. in Scientific reports 2017
These findings demonstrate that C1q and it's globular region interact with CD33 to activate its inhibitory motifs, while the collagen-like region does not. Whole C1q is required to crosslink CD33 and LAIR-1 (show LAIR1 Proteins) and concurrently activate CD33/LAIR-1 (show LAIR1 Proteins) inhibitory motifs.
rs3865444 CD33 acts as a protective factor against late-onset Alzheimer's disease.
Genetic variations in CD33 influence atrophy of specific Alzheimer's Disease-related brain structures; specifically the hippocampus and parahippocampal gyrus.
The mean percentage of CD33-positivity of the myeloblast population was 80.5% in acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)), 81.8% in chronic myelomonocytic leukemia (CMML) and 75% in myelodysplastic syndromes (MDS (show PAFAH1B1 Proteins)).
The 161533 TriKE induced superior NK cell cytotoxicity, degranulation, and cytokine production against CD33(+) HL-60 targets and increased NK survival and proliferation.
High efficacy of CD33/CD3 (show CD3 Proteins) TandAbs in various preclinical models of human AML (show RUNX1 Proteins).
The use of CD33(+)CD11b (show ITGAM Proteins)(+)HLA-DR(-) cells as a predictive and prognostic biomarker.
Data suggest that two SNPs in CD33 (rs3865444A, rs12459419T) that are protective of Alzheimer disease result in splice variants (CD33M, CD33m); CD33M localizes predominantly at cell surface in macrophage cell line; CD33m is primary intracellular form in neutrophils and a microglia cell line; intracellular CD33m accumulates in peroxisomes; activation of macrophages/neutrophils does not mobilize CD33m to cell surface.
In cutaneous diffuse large b-cell lymphoma, a considerable proportion of CD33(+) myeloid-derived suppressor cells (MDSCs) with PD-L1 (show CD274 Proteins) coexpression was admixed. Tumor cells expressed CD33 to variable degrees (2% to 60%). We propose that PD-L1 (show CD274 Proteins)(+) tumor cells and PD-L1 (show CD274 Proteins)(+) MDSCs shield the tumor against PD-1 (show PDCD1 Proteins)(+) tumor-infiltrating lymphocytes, consequently leading to inhibition and diminution of tumor-infiltrating lymphocytes.
CD33-expressing microglia play a central role in the development of leukoencephalopathy in Nasu-Hakola disease brains
Lectin galactoside-binding soluble 3 binding protein (LGALS3BP (show LGALS3BP Proteins)) is a tumor-associated immunomodulatory ligand for CD33-related Siglecs.
CD33-related Siglec-E recognizes the intact neuron and has neuroprotective function by preventing phagocytosis.
SOCS3 (show SOCS3 Proteins) inhibited the CD33-induced block on cytokine-induced proliferation. SOCS3 (show SOCS3 Proteins) and its target protein CD33 are degraded concomitantly concomitantly.
Putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules. Induces apoptosis in acute myeloid leukemia (in vitro).
CD33 antigen (gp67)
, myeloid cell surface antigen CD33
, sialic acid binding Ig-like lectin 3
, sialic acid-binding Ig-like lectin 3