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CGGBP1 influences expression of the FMR1 gene (MIM 309550), which is associated with the fragile X mental retardation syndrome (MIM 300624), by specifically interacting with the 5-prime (CGG)n-3-prime repeat in its 5-prime UTR.[supplied by OMIM, Mar 2008]..
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Human Polyclonal CGGBP1 Primary Antibody for ICC, IF - ABIN4297803
Stadler, Rexhepaj, Singan, Murphy, Pepperkok, Uhlén, Simpson, Lundberg: Immunofluorescence and fluorescent-protein tagging show high correlation for protein localization in mammalian cells. in Nature methods 2013
By studying global gene expression patterns and genome-wide DNA-binding patterns of CGGBP1, it has been shown that a possible mechanism through which it affects the expression of RNA Pol II (show 0 Antibodies)-transcribed genes in trans depends on Alu RNA.
CGGBP1 has no direct effect on FMR1 (show FMR1 Antibodies) transcription and CGG repeat stability.
CGGBP1 protein play an important cytoprotective role in patients with cancer.
CGGBP1 is a possible bidirectional regulator of CpG methylation at Alus, and acts as a repressor of methylation at L1 retrotransposons.
Our results suggest that CGGBP1 phosphorylation at S164 (show RBM25 Antibodies) is a novel telomere protection signal, which can affect telomere-protective function of the shelterin complex
Over-expression of miR-7 (show LILRB1 Antibodies) could significantly inhibit the growth of human lung cancer cells in vivo and in vitro, which might be related to the down-regulated expression of tumor growth-associated protein CGGBP1
CGGBP1 depletion by RNA interference in tumor-derived cells caused an increase in the cell population at G0/G1 phase and reduced the number of cells in the S phase.
CGGBP-20 downregulates the activity of 5'-region of FMR1 (show FMR1 Antibodies) gene in the presence of GCC (show GUCY2C Antibodies)-triplets only.
CGGBP1 was mapped to chromosome 3p and a sequence of 235 nucleotides 5' upstream of CGGBP1 is essential for promoter activity.
Cggbp1 mRNAs of 1.2 and 4.5 kb are transcribed at varying ratios in embryonic, fetal tissues.
CGGBP1 influences expression of the FMR1 gene (MIM 309550), which is associated with the fragile X mental retardation syndrome (MIM 300624), by specifically interacting with the 5-prime (CGG)n-3-prime repeat in its 5-prime UTR.
20 kDa CGG-binding protein
, CGG triplet repeat-binding protein 1
, CGG-binding protein 1
, p20-CGG binding protein
, p20-CGGBP DNA-binding protein
, CGG triplet repeat binding protein 1