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CRCP encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Additionally we are shipping CGRP Receptor Component Antibodies (19) and CGRP Receptor Component Kits (9) and many more products for this protein.
Showing 7 out of 10 products:
CGRP can inhibit microglia activation in vivo in EAE. CGRP and its receptor may represent novel protective factors in EAE.
CGRP-receptor component protein has been found to interact only with calcitonin-like receptor and represents a novel neuroendocrine regulatory step in calcitonin gene-related peptide signaling.
The mouse cDNA for calcitonin receptor-like receptor (CRLR) was cloned. The signal transduction mechanism through the CGRP receptor was studied. mCRLR is a 462-amino acid G-protein-coupled heptahelical receptor.
data reinforce and clarify our understanding of CGRP receptor localization, and provide evidence that antagonist antibodies bind to target sites in the trigeminovascular system of primates that are involved in the pathology of migraine
CGRP family of receptors displays both ligand- and RAMP-dependent signaling bias among the Galphas, Galphai, and Galphaq/11 pathways.
In this review, the influence of the CGRP family peptides in reproduction and pregnancy is explored and discussed.
This study demonstrates the detailed expression of CGRP and its receptor components within spinal trigeminal nucleus in the brainstem and in the spinal cord at C1-level
The extracellular protein domains corresponding to residues 23-133 of calcitonin receptor-like receptor and residues 26-117 of receptor activity-modifying protein 1 (RAMP1) are shown to be sufficient for formation of a stable, folded monodisperse complex.
Data describe the role of residues 23-60 of the calcitonin receptor-like receptor in binding with interaction sites within the N-terminus of the calcitonin gene-related peptide receptor.
Expression of CGRP-RCP was detected in CD34+ cells and also in some mature granulocyte samples, providing evidence that CGRP-RCP may be regulated independently of RAMP1 and CRLR in hematopoietic cells.
human CGRP-RCP is the genuine orthologue of C17. CGRP-RCP was found to functionally replace C17 in Deltarpc17 yeast cells; CGRP-RCP was identified in a purified human Pol III preparation.
inhibition of ACE seems to augment CGRP catabolism.
Increased mRNA expression CGRP-RCP in gravid myometrium supports the possibility of involvement of CGRP in the control of myometrial contractility.
A peptide mimetic demonstrates that 12 residues of family B member CGRP receptor proximal C-terminus are required for this receptor's expression and localization at the cell membrane.
analysis of the effects of antagonists to the CGRP receptor
This gene encodes a membrane protein that functions as part of a receptor complex for a small neuropeptide that increases intracellular cAMP levels. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
calcitonin gene-related peptide-receptor component protein
, DNA-directed RNA polymerase III subunit RPC9
, CGRP-receptor component protein
, RNA polymerase III subunit C9