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Three different forms of human pancreatic procarboxypeptidase A have been isolated. Additionally we are shipping Carboxypeptidase A1 (Pancreatic) Antibodies (109) and Carboxypeptidase A1 (Pancreatic) Kits (10) and many more products for this protein.
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study indicates ER stress-inducing variants in CPB1 (show CPB1 Proteins) and CPA1 are associated with pancreatic cancer susceptibility and implicate ER stress in pancreatic acinar cells in pancreatic cancer development.
Data found no significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort
Gene mutations were present in PRSS1 (show PRSS1 Proteins) in 26 patients with acute recurrent and chronic pancreatitis, SPINK1 (show SPINK1 Proteins) in 23, CTRC in 3, and CPA1 in 5. In the 31 patients with mutations in SPINK1 (show SPINK1 Proteins), CTRC, or CPA1, 16 (51.6%) had homozygous or heterozygous mutations with other mutations.
mechanism by which CPA1 variants confer increased pancreatitis risk may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity
Serum pro-CPA and CPA levels were increased in either pancreatitis or pancreatic malignancy
Data indicate that AAV-mediated latexin (show LXN Proteins) transduction or administration of a small molecule carboxypeptidase A inhibitor significantly reduced acetone-evoked nociceptive behavior after SNI.
Three different forms of human pancreatic procarboxypeptidase A have been isolated. This gene encodes a monomeric pancreatic exopeptidase involved in zymogen inhibition.
, Carboxypeptidase A1
, carboxypeptidase A1 (pancreatic)
, carboxypeptidase a1
, pancreatic procarboxypeptidase A
, pancreatic carboxypeptidase A