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Three different forms of human pancreatic procarboxypeptidase A have been isolated. Additionally we are shipping Carboxypeptidase A1 (Pancreatic) Antibodies (106) and Carboxypeptidase A1 (Pancreatic) Kits (11) and many more products for this protein.
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study indicates ER stress-inducing variants in CPB1 and CPA1 are associated with pancreatic cancer susceptibility and implicate ER stress in pancreatic acinar cells in pancreatic cancer development.
Data found no significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort
Gene mutations were present in PRSS1 in 26 patients with acute recurrent and chronic pancreatitis, SPINK1 in 23, CTRC in 3, and CPA1 in 5. In the 31 patients with mutations in SPINK1, CTRC, or CPA1, 16 (51.6%) had homozygous or heterozygous mutations with other mutations.
Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.
mechanism by which CPA1 variants confer increased pancreatitis risk may involve misfolding-induced endoplasmic reticulum stress rather than elevated trypsin activity
Serum pro-CPA and CPA levels were increased in either pancreatitis or pancreatic malignancy
A description of the ternary complex hCPA1-Zn2+-poly(acrylic acid) is included as a model of the interaction of mucoadhesive polymers with proteases in the gastrointestinal tract.
We generated a novel CPA1 N256K knock-in mouse strain, which carries the most frequently occurring human CPA1 p.N256K mutation in the mouse Cpa1 gene. The CPA1 N256K mice develop spontaneous and progressive chronic pancreatitis and exhibit signs of endoplasmic reticulum stress in their pancreas.
Data indicate that AAV-mediated latexin transduction or administration of a small molecule carboxypeptidase A inhibitor significantly reduced acetone-evoked nociceptive behavior after SNI.
Three different forms of human pancreatic procarboxypeptidase A have been isolated. This gene encodes a monomeric pancreatic exopeptidase involved in zymogen inhibition.
, Carboxypeptidase A1
, carboxypeptidase A1 (pancreatic)
, carboxypeptidase a1
, pancreatic procarboxypeptidase A
, pancreatic carboxypeptidase A