anti-Cell Division Cycle 20 Homolog (S. Cerevisiae) (CDC20) Antibodies

Human Cell Division Cycle 20 Homolog (S. Cerevisiae) (CDC20) interaction partners

1. we demonstrate that the CDC20-MAD2 (show MAD2L1 Antibodies) complex could also be formed independently of the SAC (show ADCY10 Antibodies). Moreover, in prolonged arrest caused by nocodazole treatment, the overall levels of the CDC20-MAD2 (show MAD2L1 Antibodies) complex are gradually, but significantly, reduced and this is associated with lower levels of cyclin B1 (show CCNB1 Antibodies), which brings a new insight into the mechanism of mitotic "slippage" of the arrested cells.

2. Cdc20 may be a promising molecular target for chemotherapy.

3. Long non-coding RNA SPRY4 (show SPRY4 Antibodies)-IT1 (show HAUS3 Antibodies) promotes cell proliferation and invasion by regulation of Cdc20 in pancreatic cancer cells

4. Cdc20 functions as an important negative regulator of SMAR1 (show BANP Antibodies) in higher grades of cancer

5. Data provide support for the recent structure-based models and functionally dissect three elements of Cdc20 inhibition: sequestration of Cdc20 in the core mitotic checkpoint (show BUB3 Antibodies) complex, sufficient at low Cdc20 concentrations; inhibition of a second Cdc20 through the Mad3 (show SMAD3 Antibodies) C terminus, independent of Mad2 (show MAD2L1 Antibodies) binding to this Cdc20 molecule; and occupancy of the APC (show APC Antibodies)/C with full MCC (show MCC Antibodies), where Mad3 (show SMAD3 Antibodies) and Apc15 (show ANAPC15 Antibodies) are involved.

6. CDC20 gene, related to cell proliferation in protein complex A, might play momentous roles in the initiation and development of consecutive Trauma-Induced Sepsis.

7. A mitotic phosphorylation site on Cdc20, known to be a substrate of PP2A (show PPP2R4 Antibodies)(B56), modulates APC (show APC Antibodies)/C(Cdc20) assembly.

8. c-Myc (show MYC Antibodies) is a driver when combined with kRas/Akt3 (show AKT3 Antibodies) oncogenic signals in gliomagenesis, whereas Cdc20 overexpression is a passenger

9. The ABBA (show MTSS1L Antibodies)-KEN (show PCNT Antibodies)-ABBA (show MTSS1L Antibodies) amino acid motif cassette holds the Mitotic Checkpoint (show BUB3 Antibodies) Complex (MCC (show MCC Antibodies)) onto the Anaphase-Promoting Complex-Cyclosome (APC (show APC Antibodies)/C) by binding the two Cdc20 molecules in the MCC (show MCC Antibodies)-APC (show APC Antibodies)/C complex.

10. It discuses the roles of Cdc20 in SAC (show ADCY10 Antibodies) signalling and mitotic exit, describe how the integration of traditional approaches with emerging technologies has revealed new details of Cdc20 functions, comment about the potential of Cdc20 as a therapeutic target for the treatment of human malignancies.

Xenopus laevis Cell Division Cycle 20 Homolog (S. Cerevisiae) (CDC20) interaction partners

1. Cdc20 auto-ubiquitylation does not play a major role in terminating Cdc20 activation.

2. Dephosphorylation of Cdc20 is required for its loading and activation of the APC/C ubiquitin ligase.

3. A role for the fizzy/cdc20 family of proteins in activation of the APC (show APC Antibodies)/C distinct from substrate recruitment is reported.

Mouse (Murine) Cell Division Cycle 20 Homolog (S. Cerevisiae) (CDC20) interaction partners

1. Cdc20 hypomorphism causes chromatin bridging and chromosome misalignment, revealing a requirement for Cdc20 in efficient sister chromosome separation and chromosome-microtubule attachment.

2. The physiologically effective threshold level of Cdc20 is high for female meiosis I.

3. Results indicate that Cdc20 also contributes to post-anaphase activation of the APC (show APC Antibodies)/C.

4. The seven tandem WD motifs of Cdc20 they are required for speriolin binding and for localization of Cdc20 to the centrosomes and nucleus, suggesting that speriolin might regulate or stabilize the folding of Cdc20 during meiosis in spermatogenic cells

5. Data suggest that Mad2 (show MXI1 Antibodies) and BubR1 (show BUB1B Antibodies) must cooperate to inhibit Cdc20 activity.

6. Cdc20 is degraded through two independent degradation signals (degrons), the KEN (show PCNT Antibodies) box and a newly described CRY (show CRY2 Antibodies) box.

7. Cdc20 and securin (show PTTG1 Antibodies) double mutant embryos could not maintain the metaphase arrest, suggesting a role of securin (show PTTG1 Antibodies) in preventing mitotic exit

8. Expression of the cdc20 gene is down-regulated by zif268 (show EGR1 Antibodies) in neuronal cells; altered expression of proteasome-regulatory genes following zif268 (show EGR1 Antibodies) induction may be a key component of long-lasting CNS plasticity.

9. Cdc20 is required for the anaphase onset of the first meiosis but not the second meiosis in mouse oocytes

10. findings suggest a novel function of HSF1 (show HSF1 Antibodies) frequently overexpressed in cancer cells, to inhibit APC (show APC Antibodies)/C activity by interacting with Cdc20, and to result in aneuploidy development and genomic instability

Pig (Porcine) Cell Division Cycle 20 Homolog (S. Cerevisiae) (CDC20) interaction partners

1. porcine FZR1 (show FZR1 Antibodies) and CDC20 work on the maintenance of meiotic arrest at the first meiotic prophase and on the exit from M1