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Negative regulator of Notch signaling pathway involved furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. Additionally we are shipping CHAC1 Antibodies (56) and and many more products for this protein.
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Study have shown that the 5' UTR of Chac1 plays an important role in expressing the full-length and short form of Chac1, and the expression level of Chac1 protein is predominantly regulated by its ubiquitination.
Chac1 expression is detrimental to arsenite-treated cell survival and TRIB3 is critical for restraining the pro-death potential of Chac1 during arsenite stress.
Data indicate that Chac1 protein expression was only detected in the presence of MG132, a proteasome inhibitor.
The ChaC family is conversed across all phyla and represents a new pathway for glutathione degradation in living cells, and the first cytosolic pathway for glutathione degradation in mammalian cells.
The data revealed that CHAC2 prevented CHAC1-mediated GSH degradation, which suggests that CHAC2 competes with CHAC1 to maintain GSH homeostasis.
Temozolomide (TMZ)-mediated gene expression profiles and networks are involved in inducing glioblastoma cell death. Increased CHAC1 and reduced Notch3 levels are both also significantly involved in TMZ-mediated cytotoxicity. The TMZ-regulated CHAC1 pathway inhibits Notch3 activation, resulting in attenuation of Notch3-mediated signaling pathways.
Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 and ATF3 and a Bipartite ATF/CRE Regulatory Element.
Botch regulates Notch signaling through deglycination and identify a posttranslational modification of Notch that plays an important role in neurogenesis.
nisin exerts these effects on HNSCC, in part, through CHAC1, a proapoptotic cation transport regulator, and through a concomitant CHAC1-independent influx of extracellular calcium
High CHAC1 mRNA expression could be an independent indicator for elevated risk of cancer recurrence in breast and ovarian cancer
Negative regulator of Notch signaling pathway involved furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. May also act as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (By similarity).
cation transport regulator-like protein 1
, ChaC, cation transport regulator-like 1
, ChaC, cation transport regulator homolog 1 (E. coli)
, blocks Notch protein
, cation transport regulator homolog 1
, neuroprotective protein 7