ChaC, Cation Transport Regulator Homolog 1 (E. Coli) Proteins (CHAC1)

Negative regulator of Notch signaling pathway involved furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. Additionally we are shipping CHAC1 Antibodies (54) and and many more products for this protein.

list all proteins Gene Name GeneID UniProt
CHAC1 69065 Q8R3J5
CHAC1 79094 Q9BUX1
Rat CHAC1 CHAC1 362196 B3STU3
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Top CHAC1 Proteins at antibodies-online.com

Showing 4 out of 5 products:

Catalog No. Origin Source Conjugate Images Quantity Supplier Delivery Price Details
Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
Insect Cells Mouse His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
$6,869.04
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Log in to see Available
$547.80
Details
Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
$328.90
Details

CHAC1 Proteins by Origin and Source

Origin Expressed in Conjugate
Mouse (Murine)

Human , ,
, ,

More Proteins for ChaC, Cation Transport Regulator Homolog 1 (E. Coli) (CHAC1) Interaction Partners

Mouse (Murine) ChaC, Cation Transport Regulator Homolog 1 (E. Coli) (CHAC1) interaction partners

  1. Study have shown that the 5' UTR of Chac1 plays an important role in expressing the full-length and short form of Chac1, and the expression level of Chac1 protein is predominantly regulated by its ubiquitination.

  2. Chac1 expression is detrimental to arsenite-treated cell survival and TRIB3 (show TRIB3 Proteins) is critical for restraining the pro-death potential of Chac1 during arsenite stress.

  3. Data indicate that Chac1 protein expression was only detected in the presence of MG132, a proteasome inhibitor.

  4. The ChaC family is conversed across all phyla and represents a new pathway for glutathione degradation in living cells, and the first cytosolic pathway for glutathione degradation in mammalian cells.

Human ChaC, Cation Transport Regulator Homolog 1 (E. Coli) (CHAC1) interaction partners

  1. The data revealed that CHAC2 prevented CHAC1-mediated GSH degradation, which suggests that CHAC2 competes with CHAC1 to maintain GSH homeostasis.

  2. Temozolomide (TMZ)-mediated gene expression profiles and networks are involved in inducing glioblastoma cell death. Increased CHAC1 and reduced Notch3 (show NOTCH3 Proteins) levels are both also significantly involved in TMZ-mediated cytotoxicity. The TMZ-regulated CHAC1 pathway inhibits Notch3 (show NOTCH3 Proteins) activation, resulting in attenuation of Notch3 (show NOTCH3 Proteins)-mediated signaling pathways.

  3. Human CHAC1 Protein Degrades Glutathione, and mRNA Induction Is Regulated by the Transcription Factors ATF4 (show ATF4 Proteins) and ATF3 (show ATF3 Proteins) and a Bipartite ATF/CRE Regulatory Element.

  4. Botch regulates Notch (show NOTCH1 Proteins) signaling through deglycination and identify a posttranslational modification of Notch (show NOTCH1 Proteins) that plays an important role in neurogenesis.

  5. nisin exerts these effects on HNSCC, in part, through CHAC1, a proapoptotic cation transport regulator, and through a concomitant CHAC1-independent influx of extracellular calcium

  6. High CHAC1 mRNA expression could be an independent indicator for elevated risk of cancer recurrence in breast and ovarian cancer

CHAC1 Protein Profile

Protein Summary

Negative regulator of Notch signaling pathway involved furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos. May also act as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (By similarity).

Gene names and symbols associated with CHAC1

  • ChaC glutathione specific gamma-glutamylcyclotransferase 1 (CHAC1)
  • ChaC, cation transport regulator 1 (Chac1)
  • ChaC glutathione-specific gamma-glutamylcyclotransferase 1 (Chac1)
  • 1810008K03Rik protein
  • RGD1307153 protein

Protein level used designations for CHAC1

cation transport regulator-like protein 1 , ChaC, cation transport regulator-like 1 , ChaC, cation transport regulator homolog 1 (E. coli) , blocks Notch protein , botch , cation transport regulator homolog 1 , neuroprotective protein 7

GENE ID SPECIES
423209 Gallus gallus
467659 Pan troglodytes
705007 Macaca mulatta
100219118 Taeniopygia guttata
69065 Mus musculus
79094 Homo sapiens
487504 Canis lupus familiaris
505991 Bos taurus
362196 Rattus norvegicus
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