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CXCR3 encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Additionally we are shipping CXCR3 Antibodies (339) and CXCR3 Kits (53) and many more products for this protein.
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CD4(+)CXCR3(+) T cells are h (show LY75 Proteins)ighly enriched in the inflamed mucosa (show IL10 Proteins) of intestinal bowel disease patients.
CCL27 (show CCL27 Proteins) drives baseline recruitment of Herpes simplex virus-specific CD8 (show CD8A Proteins) T cells expressing CCR10 (show CCR10 Proteins), while interferon (show IFNA Proteins)-responsive CXCR3 ligands recruit additional cells in response to virus-driven inflammation.
Up-regulation of CXCR3 chemokine (show CCL1 Proteins) and its ligands in bronchoalveolar lavage fluid during organizing pneumonia increases the risk of chronic lung allograft dysfunction after lung transplantation.
These data suggest that elevated IP-10 (show CXCL10 Proteins) levels may impair NK cell function during HIV infection and that IP-10 (show CXCL10 Proteins)/CXCR3 blocking may be a novel therapeutic strategy in the control and functional cure of HIV.
Our result showed that CXCR2 (show CXCR2 Proteins) expression was correlated with high grade (P = 0.024), advanced stage (P = 0.029) and metastasis (P = 0.018). The log-rank test revealed that high CXCR2 (show CXCR2 Proteins) and CXCR3 expressions are related to poorer overall survival (P < 0.001; P < 0.001).
The percentage of CXCR3(+) CD4 (show CD4 Proteins)(+) TEM (show CYLD Proteins) cells negatively correlated with the severity of the cutaneous disease in psoriasis patients. Importantly CLA (show SELPLG Proteins)(+) CD4 (show CD4 Proteins)(+) TCM cells expressing CCR6 (show CCR6 Proteins)(+) or CCR4 (show CCR4 Proteins)(+)CXCR3(+) negatively correlated with psoriasis severity suggesting recruitment to the skin compartment.
Our studies suggest that CXCR3 is a key contributor to the pathogenesis of Alopecia areata by mediating the infiltration of autoreactive CD8 (show CD8A Proteins)+NKG2D (show KLRK1 Proteins)+ T cells into the skin
TNF-alpha (show TNF Proteins) augments CXCR2 (show CXCR2 Proteins) and CXCR3 to promote the progression of renal cell carcinoma (show MOK Proteins) leading to a poor prognosis.
TLR9 (show TLR9 Proteins) ligands may contribute to the immunopathogenesis of sarcoidosis via induction of CXCL10 (show CXCL10 Proteins) release in the alveolar macrophages.
The CXCL10 (show CXCL10 Proteins)/CXCR3 axis mediates T-cell recruitment into the skin in progressive vitiligo (show MITF Proteins). Blocking this chemotactic mechanism may present a new form of therapy.
Data suggest that the CXCL9 (show CXCL9 Proteins)-CXCR3 axis plays a pivotal role in the liver-specific distribution of TRAIL+ NK cells in mice.
ATF3 (show ATF3 Proteins)-KO mice escape from PE-dependent maladaptive cardiac remodeling by suppressing the IFNgamma-CXCL10 (show CXCL10 Proteins)-CXCR3 axis at multiple levels.
study thus shows that lung mucosal-resident memory T cells are not generated following systemic TB immunization and that local inflammation is required for systemically activated T cells to home to lung mucosa, which is mediated by interaction between CXCR3 upregulated in these cells and its ligands IP-10 (show CXCL10 Proteins) and MIG (show CXCL9 Proteins)
Antigen targeting to DEC-205 (show LY75 Proteins) on dendritic cells leads to an IL-10 (show IL10 Proteins)-dependent downregulation of CXCR3 expression on differentiated antigen-specific Th1 (show HAND1 Proteins) cells in vivo. This downregulation interferes with the migration of Th1 (show HAND1 Proteins) cells into the gut (show GUSB Proteins) and protects mice against severe acute and relapsing intestinal inflammation.
this study shows that neutrophils and NK cells act as important disease-promoting immune cells in experimental osteoarthritis and their functional interaction is promoted by the CXCL10 (show CXCL10 Proteins)/CXCR3 axis
These results demonstrate a critical role for both BLT1 and CXCR3 in cytotoxic T lymphocyte (CTL) migration to tumors and thus may be targeted to enhance efficacy of CTL-based immunotherapies.
Cxcr3 is up-regulated by DNA demethylation and interaction with C/EBPalpha (show CEBPA Proteins) which contributes to neuropathic pain.
These findings demonstrate that the CXCL10 (show CXCL10 Proteins)/CXCR3 chemokine (show CCL1 Proteins) pathway is critical in shaping CD8 (show CD8A Proteins)(+) T cell immunity, locally within latently infected tissues, which protects against recurrent herpesvirus infection and disease.
this study shows that although T cell-specific expression of CXCR3 promotes the accumulation of CXCR3-expressing T cells during Leishmania donovani infection, this does not enhance resistance to visceral leishmaniasis; hepatic granuloma formation is impaired in CXCR3 transgenic mice
Transcript analysis showed that antigen stimulation of WC1(+)gammadelta T cells substantially increased CXCR3 expression
This gene encodes a G protein-coupled receptor with selectivity for three chemokines, termed CXCL9/Mig (monokine induced by interferon-g), CXCL10/IP10 (interferon-g-inducible 10 kDa protein) and CXCL11/I-TAC (interferon-inducible T cell a-chemoattractant). Binding of chemokines to this protein induces cellular responses that are involved in leukocyte traffic, most notably integrin activation, cytoskeletal changes and chemotactic migration. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. One of the isoforms (CXCR3-B) shows high affinity binding to chemokine, CXCL4/PF4 (PMID:12782716).
chemokine (C-X-C motif) receptor 3
, C-X-C chemokine receptor type 3
, G protein-coupled receptor 9
, IP-10 receptor
, IP10 receptor
, Mig receptor
, chemokine (C-X-C) receptor 3
, interferon-inducible protein 10 receptor
, CXC chemokine receptor 3
, Interferon-inducible protein 10 receptor