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The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors.
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Rat (Rattus) Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for WB - ABIN965894
Zhou, Fryer, Jacoby: Structure of the human M(2) muscarinic acetylcholine receptor gene and its promoter. in Gene 2001
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Human Monoclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for IHC, IHC (fro) - ABIN4336776
Levey, Edmunds, Hersch, Wiley, Heilman: Light and electron microscopic study of m2 muscarinic acetylcholine receptor in the basal forebrain of the rat. in The Journal of comparative neurology 1995
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Human Monoclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for Func, IA - ABIN2192224
Elies, Fu, Eftekhari, Wallukat, Schulze, Granier, Hjalmarson, Hoebeke: Immunochemical and functional characterization of an agonist-like monoclonal antibody against the M2 acetylcholine receptor. in European journal of biochemistry / FEBS 1998
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Dog (Canine) Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for IF (p), IHC (p) - ABIN668646
Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. in Basic research in cardiology 2014
Cow (Bovine) Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for IHC (p) - ABIN4336774
Strang, Renna, Amthor, Keyser: Muscarinic acetylcholine receptor localization and activation effects on ganglion response properties. in Investigative ophthalmology & visual science 2010
Mouse (Murine) Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for ELISA, WB - ABIN4336778
Hendershot, Bryan, Ewing, Claus, Hutchison: Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence. in Journal of abnormal child psychology 2011
Bat Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for IHC (p) - ABIN270607
Yankiwski, Noonan, Neff: The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability. in BMC cell biology 2002
Two single nucleotide polymorphisms in CHRM2 gene, rs2061174 and rs6948054, showed significant difference in genotype distribution between medical and fine arts students (p<0.05). The rs2061174 showed significant at p = 0.001, OR and 95% CI were 3.78 (2.00-7.14), whereas the rs6948054 was significant at p = 0.012, OR and 95% CI were 2.50 (1.32-4.77).
Graded activation and free energy landscapes of a muscarinic G-protein-coupled M2 receptor has been reported.
With final functional experiments on six selected compounds, we confirmed four of them as new negative allosteric modulators (NAMs) and one as positive allosteric modulator of agonist-mediated response at the M2 mAChR (show CHRM3 Antibodies)
Results show reduced autonomic nervous system (ANS) activity in association with the CHRM2 rs8191992 polymorphism in patients with schizophrenia on high-dose antipsychotics. CHRM2 polymorphisms may play an important role in ANS activity in patients with schizophrenia.
Data suggest that levels of CHRM2 are lower in Brodmann's area 24 from subjects with mood disorders, and it is possible that signalling by that receptor is also less in this cortical region; increasing levels of CHRM2 may be involved in the mechanisms of action of mood stabilisers and tricyclic antidepressants
Report a significant association between CHRM2 (rs1824024) polymorphism and disease severity, lower lung function test values, frequent exacerbations, and poor response to anti-cholinergic drugs in COPD (show ARCN1 Antibodies) patients.
Inactivation of M2 AChR/NF-kappaB (show NFKB1 Antibodies) signaling axis reverses epithelial-mesenchymal transition and suppresses migration and invasion in non-small cell lung cancer.
CHRM2 gene expression was dysregulated in the anterior cingulate of bipolar patients.
This study demonstrated that CD4 (show CD4 Antibodies)+ and CD8 (show CD8A Antibodies)+ T cells expressed M2 and M4 muscarinic receptors which density were significantly increased in asthmatic children in comparison with controls.
The expressed the fusion proteins of the muscarinic acetylcholine receptor M2 subtype with a maltose-binding protein and various G protein alpha (show GNAO1 Antibodies) subunits in Escherichia coli.
The three receptor sets considered (mAChR (show CHRM3 Antibodies), AR and TrkB (show NTRK2 Antibodies) receptors) intervene in modulating the conditions of the competition between nerve endings.
In the present study, the functional coupling of Gi/o protein-coupled receptors to GalR1 (show GALR1 Antibodies), and the CB1 (show CNR1 Antibodies) receptor subtype for endocannabinoids were analyzed in the 3xTg-AD mice model of Alzheimer's disease in the prodromal and advanced stages. In addition, the activity mediated by Gi/o protein-coupled M2/4 (show GSDMD Antibodies) muscarinic receptor (show CHRM5 Antibodies) subtypes was also analyzed in brain areas involved in anxiety and cognition.
Muscarinic M2 receptors in the circular muscular layer of mouse ileum exert a previously undocumented function in gut (show GUSB Antibodies) motility via the regulation of gap junctions
IL-17 (show IL17A Antibodies) production in the hearts of M2AChR mice is dependent on P2x7 (show P2RX7 Antibodies) expression in dilated cardiomyopathy.
Expression of the M2 receptors mediating cholinergic contractile stimuli of the detrusor muscle was dysregulated in both Mras (show MRAS Antibodies)-/- males and females, although only males exhibited a urinary phenotype.
These results demonstrate that M2R are dysfunctional and do not affect ACh levels in PRiMA knockout mice, likely because of down-regulation and/or loss of receptor-effector coupling.
Data indicate taht m2R-RGS6 (show RGS6 Antibodies)-IKACh pathway sets heart rate variability independently from the autonomic input.
M2-mediated contractions in the M3KO and WT strains were decreased by the Rho kinase (show ROCK2 Antibodies) (ROCK) inhibitor Y27632 as well as the ROCK, PKA and PKG (show PRKG1 Antibodies) inhibitor H89.
M2 receptor is co-localized with VGLUT2 on intraganglionic laminar endings of esophagus.
Presence of M2 mAChR (show CHRM3 Antibodies) is sufficient and necessary to mediate the carbachol-induced membrane hyperpolarization and inhibition of SpECTs in laterodorsal tegmental nucleus neurons.
cloning, characterization and expression patterns; results suggest that the M2 mAChR (show CHRM3 Antibodies) inhibits basal heart rate in zebrafish embryo and mediates carbachol-induced bradycardia
The M(2) muscarinic receptor (show CHRM5 Antibodies) plays a specific role in the initiation of hypoxic bradycardia in fish.
Data suggest that both M(2) and M(3) muscarinic receptors mediate the contraction in both pig clasp (show CLASRP Antibodies) and sling fibers similar to human clasp (show CLASRP Antibodies) and sling fibers.
The original finding was the identification and purification of a vinpocetine and muscarinic antagonist-inhibited and CaM (show KRIT1 Antibodies)-activated plasma membrane-bound PDE1A (show PDE1A Antibodies), linked to M(2)AChR.
airway M(2)Rs inhibit BK channels by a dual, Gbetagamma-mediated mechanism, a direct membrane-delimited interaction, and the activation of the phospholipase C (show PLC Antibodies)/protein kinase C (show PKC Antibodies) pathway
Data suggest that autoantibodies to beta-1 adrenergic receptor (ADRB1 (show ADRB1 Antibodies)) and muscarinic receptor M2 (CHRM2), along with elevated thyroxine (T4) levels, contribute to atrial tachyarrhythmia in Graves disease (GD); here, a rabbit model of GD is studied.
The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.
, acetylcholine receptor, muscarinic 2
, muscarinic M2 receptor
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, AChR M2
, muscarinic acetylcholine receptor 2
, cholinergic receptor, muscarinic 2
, cardiac muscarinic acetylcholine receptor
, muscarinic acetylcholine receptor m2
, m2 muscarinic acetylcholine receptor
, Muscarinic acetylcholine receptor M2
, cholinergic receptor muscarinic 2
, muscarinic acetylcholine receptor M2-like
, M2 muscarinic acetylcholine receptor
, cholinergic receptor, muscarinic 2, cardiac
, muscarinic receptor m2
, muscarinic receptor 2