anti-Cholinergic Receptor, Muscarinic 2 (CHRM2) Antibodies

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. Additionally we are shipping Muscarinic Acetylcholine Receptor M2 Kits (64) and Muscarinic Acetylcholine Receptor M2 Proteins (10) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CHRM2 1129 P08172
CHRM2 243764 Q9ERZ4
CHRM2 81645 P10980
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Top anti-Muscarinic Acetylcholine Receptor M2 Antibodies at antibodies-online.com

Showing 10 out of 164 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Mouse Rabbit Un-conjugated WB Western blot analysis of CHRM2 expression in rat brain extract ( Lane 1) and mouse brain extract ( Lane 2). CHRM2 at 52KD was detected using rabbit anti- CHRM2 Antigen Affinity purified polyclonal antibody (Catalog #) at 0.5 µg/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from HeLa/MCF-7 cells, using CHRM2 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of LOVO cells, using CHRM2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB CHRM2 Antibody (Center)  western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CHRM2 antibody detected the CHRM2 protein (arrow). Western blot analysis of CHRM2 (arrow) using rabbit polyclonal CHRM2 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CHRM2 gene. 400 μL Log in to see 10 to 11 Days
$385.00
Details
Mouse Goat Un-conjugated ELISA, WB   100 μg Log in to see 6 to 7 Days
$429.84
Details
Bat Rabbit Un-conjugated IHC, IHC (p) Anti-CHRM2 antibody  ABIN1048439 IHC staining of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-CHRM2 / M2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Cow Rabbit Un-conjugated IHC, IHC (p) Anti-CHRM2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1048441 dilution 10 ug/ml. Anti-CHRM2 antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1048441 dilution 10 ug/ml. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Human Rabbit Un-conjugated IHC, IHC (p) Anti-CHRM2 antibody  ABIN1048438 IHC staining of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-CHRM2 antibody IHC of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Cow Rabbit Un-conjugated IHC, IHC (p) Anti-CHRM2 antibody  ABIN1048440 IHC staining of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Anti-CHRM2 / M2 antibody IHC of human Brain, Glioblastoma. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 11 to 14 Days
$484.00
Details
Cow Goat Un-conjugated ELISA, WB 100 μg Log in to see 11 to 14 Days
$610.50
Details
Rat Rabbit Un-conjugated WB Lane 1: Rat brain tissue Lysate. Lane 2: Rat brain tissue Lysate. Lane 3: Rat medulla tissue Lysate. Lane 4: Rat medulla tissue Lysate. 0.1 mg Log in to see 6 to 8 Days
$456.50
Details

Top referenced anti-Muscarinic Acetylcholine Receptor M2 Antibodies

  1. Rat (Rattus) Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for WB - ABIN965894 : Zhou, Fryer, Jacoby: Structure of the human M(2) muscarinic acetylcholine receptor gene and its promoter. in Gene 2001 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for Func, IA - ABIN2192224 : Elies, Fu, Eftekhari, Wallukat, Schulze, Granier, Hjalmarson, Hoebeke: Immunochemical and functional characterization of an agonist-like monoclonal antibody against the M2 acetylcholine receptor. in European journal of biochemistry / FEBS 1998 (PubMed)
    Show all 2 Pubmed References

  3. Dog (Canine) Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for IF (p), IHC (p) - ABIN668646 : Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. in Basic research in cardiology 2014 (PubMed)

  4. Bat Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for IHC (p) - ABIN270607 : Yankiwski, Noonan, Neff: The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability. in BMC cell biology 2002 (PubMed)

  5. Cow (Bovine) Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for IHC (p) - ABIN4336774 : Strang, Renna, Amthor, Keyser: Muscarinic acetylcholine receptor localization and activation effects on ganglion response properties. in Investigative ophthalmology & visual science 2010 (PubMed)

  6. Mouse (Murine) Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for ELISA, WB - ABIN4336778 : Hendershot, Bryan, Ewing, Claus, Hutchison: Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence. in Journal of abnormal child psychology 2011 (PubMed)

More Antibodies against Muscarinic Acetylcholine Receptor M2 Interaction Partners

Human Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. A key step in CHRM2 activation is the exchange of a Na+ ion from an extracellular binding pocket to the cytoplasm.

  2. Ligation of the identical phosphopeptide onto the beta2AR, the muscarinic acetylcholine receptor 2 and the mu-opioid receptor reveals that the ability of beta-arrestin1 to enhance agonist binding relative to G protein differs substantially among receptors.

  3. Data suggests that RBM24 binds to coding region of CHRM2 to regulate mRNA stability in cardiomyocytes; RBM24appears to drive changes in alternative splicing and in production of alternative transcript isoforms. (RBM24 = RNA binding motif protein-24; CHRM2 = cholinergic receptor muscarinic 2)

  4. T allele carrying status (GT and TT) [rs1824024] of muscarinic cholinergic receptor 2 (CHRM2) may be associated with delirium tremens.

  5. Two single nucleotide polymorphisms in CHRM2 gene, rs2061174 and rs6948054, showed significant difference in genotype distribution between medical and fine arts students (p<0.05). The rs2061174 showed significant at p = 0.001, OR and 95% CI were 3.78 (2.00-7.14), whereas the rs6948054 was significant at p = 0.012, OR and 95% CI were 2.50 (1.32-4.77).

  6. complex between M2R and holo-Gi1 is an octamer comprising four copies of each, and that activation is accompanied by a decrease in the oligomeric size of Gi1

  7. Graded activation and free energy landscapes of a muscarinic G-protein-coupled M2 receptor has been reported.

  8. With final functional experiments on six selected compounds, we confirmed four of them as new negative allosteric modulators (NAMs) and one as positive allosteric modulator of agonist-mediated response at the M2 mAChR

  9. Results show reduced autonomic nervous system (ANS) activity in association with the CHRM2 rs8191992 polymorphism in patients with schizophrenia on high-dose antipsychotics. CHRM2 polymorphisms may play an important role in ANS activity in patients with schizophrenia.

  10. Data suggest that levels of CHRM2 are lower in Brodmann's area 24 from subjects with mood disorders, and it is possible that signalling by that receptor is also less in this cortical region; increasing levels of CHRM2 may be involved in the mechanisms of action of mood stabilisers and tricyclic antidepressants

  11. These results suggest that the M2 receptors may represent a new interesting therapeutic tool to counteract glioblastoma cancer stem cell growth and survival.

  12. Report a significant association between CHRM2 (rs1824024) polymorphism and disease severity, lower lung function test values, frequent exacerbations, and poor response to anti-cholinergic drugs in COPD patients.

  13. Inactivation of M2 AChR/NF-kappaB signaling axis reverses epithelial-mesenchymal transition and suppresses migration and invasion in non-small cell lung cancer.

  14. CHRM2 gene expression was dysregulated in the anterior cingulate of bipolar patients.

  15. Higher serum anti-M2-R and anti-beta1-R levels are associated with lone paroxysmal atrial fibrillation.

  16. This study demonstrated that CD4+ and CD8+ T cells expressed M2 and M4 muscarinic receptors which density were significantly increased in asthmatic children in comparison with controls.

  17. The expressed the fusion proteins of the muscarinic acetylcholine receptor M2 subtype with a maltose-binding protein and various G protein alpha subunits in Escherichia coli.

  18. CHRM2 but not CHRM1 or CHRM3 polymorphisms are associated with asthma susceptibility in Mexican patients.

  19. High Muscarinic Receptor M2 expression is associated with peripartum cardiomyopathy.

  20. It was the M(2) receptor pharmacology.

Mouse (Murine) Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. The three receptor sets considered (mAChR, AR and TrkB receptors) intervene in modulating the conditions of the competition between nerve endings.

  2. In the present study, the functional coupling of Gi/o protein-coupled receptors to GalR1, and the CB1 receptor subtype for endocannabinoids were analyzed in the 3xTg-AD mice model of Alzheimer's disease in the prodromal and advanced stages. In addition, the activity mediated by Gi/o protein-coupled M2/4 muscarinic receptor subtypes was also analyzed in brain areas involved in anxiety and cognition.

  3. We found that knockout of the M2/3 receptor significantly inhibited ST37 acupuncture-induced enhancement of gastric motility, jejunal motility, and colonic motility.

  4. Muscarinic M2 receptors in the circular muscular layer of mouse ileum exert a previously undocumented function in gut motility via the regulation of gap junctions

  5. IL-17 production in the hearts of M2AChR mice is dependent on P2x7 expression in dilated cardiomyopathy.

  6. Expression of the M2 receptors mediating cholinergic contractile stimuli of the detrusor muscle was dysregulated in both Mras-/- males and females, although only males exhibited a urinary phenotype.

  7. These results demonstrate that M2R are dysfunctional and do not affect ACh levels in PRiMA knockout mice, likely because of down-regulation and/or loss of receptor-effector coupling.

  8. Beta-2-Adrenergic and M2-muscarinic receptors decrease basal t-tubular L-type calcium channel activity and suppress ventricular contractility in heart failure.

  9. Data indicate taht m2R-RGS6-IKACh pathway sets heart rate variability independently from the autonomic input.

  10. the M3 receptor has a pro-inflammatory role in cigarette smoke-induced neutrophilia and cytokine release, yet M1 and M2 receptors have an anti-inflammatory role

  11. M2 receptors play an essential role in the generation of intestinal rhythmic motor activity, and M3 receptors have a modulatory role in controlling the periodicity of the rhythmic activity

  12. These results suggest for the first time a role of M2 in growth-related changes in extracellular matrix genes during myopia development in a mammalian model.

  13. M2-mediated contractions in the M3KO and WT strains were decreased by the Rho kinase (ROCK) inhibitor Y27632 as well as the ROCK, PKA and PKG inhibitor H89.

  14. M2 receptor is co-localized with VGLUT2 on intraganglionic laminar endings of esophagus.

  15. The m2 receptor is concentrated at cholinergic synapses located on the perikarya and most proximal dendrites, and enriched at glutamatergic synapses both in perikarya and dendrites.

  16. Presence of M2 mAChR is sufficient and necessary to mediate the carbachol-induced membrane hyperpolarization and inhibition of SpECTs in laterodorsal tegmental nucleus neurons.

  17. In muscararinic M2 receptor knockout mice, although the main cardioinhibitory receptors are not present in the heart, the function is not much affected

  18. This study demonstrated that cholinergic projections recruit M(2) receptors to redistribute the gain of LTP in CA3 pyramidal cells in an input-specific manner

  19. The function of M2 MR is substituted by beta3-AR and that these effects are mediated via adenylyl cyclase rather than NOS.

  20. The results suggested that myocarditis and dilated cardiomyopathy associated with the presence of autoantibodies aginst M2 muscarinic acetylcholine receptors are autoimmune diseases.

Zebrafish Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. cloning, characterization and expression patterns; results suggest that the M2 mAChR inhibits basal heart rate in zebrafish embryo and mediates carbachol-induced bradycardia

  2. The M(2) muscarinic receptor plays a specific role in the initiation of hypoxic bradycardia in fish.

Pig (Porcine) Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. Data suggest that both M(2) and M(3) muscarinic receptors mediate the contraction in both pig clasp and sling fibers similar to human clasp and sling fibers.

  2. Expression and function of M2 and M3 receptors are similar in the detrusor of juvenile and mature pigs.

  3. M2 and M3 receptors are upregulated in a time-dependent and pressure-dependent fashion after as little as a 24 h exposure to increased hydrostatic pressure in bladder

Cow (Bovine) Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. The original finding was the identification and purification of a vinpocetine and muscarinic antagonist-inhibited and CaM-activated plasma membrane-bound PDE1A, linked to M(2)AChR.

  2. airway M(2)Rs inhibit BK channels by a dual, Gbetagamma-mediated mechanism, a direct membrane-delimited interaction, and the activation of the phospholipase C/protein kinase C pathway

Rabbit Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. The effect of ACh on Src activity, sGC phosphorylation, and on GSNO-stimulated sGC activity and cGMP formation were blocked by the m2 receptor antagonist

  2. Data suggest that autoantibodies to beta-1 adrenergic receptor (ADRB1) and muscarinic receptor M2 (CHRM2), along with elevated thyroxine (T4) levels, contribute to atrial tachyarrhythmia in Graves disease (GD); here, a rabbit model of GD is studied.

Muscarinic Acetylcholine Receptor M2 (CHRM2) Antigen Profile

Protein Summary

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.

Gene names and symbols associated with CHRM2

  • cholinergic receptor muscarinic 2 (CHRM2) antibody
  • cholinergic receptor, muscarinic 2, cardiac (Chrm2) antibody
  • cholinergic receptor, muscarinic 2a (chrm2a) antibody
  • cholinergic receptor, muscarinic 2 (Chrm2) antibody
  • cholinergic receptor muscarinic 2 (Chrm2) antibody
  • AChR-M2 antibody
  • Acm2 antibody
  • Chrm-2 antibody
  • chrm2 antibody
  • GPM2 antibody
  • HM2 antibody
  • M2 antibody

Protein level used designations for CHRM2

7TM receptor , acetylcholine receptor, muscarinic 2 , muscarinic M2 receptor , muscarinic acetylcholine receptor M2 , AChR M2 , muscarinic acetylcholine receptor 2 , cholinergic receptor, muscarinic 2 , cardiac muscarinic acetylcholine receptor , muscarinic acetylcholine receptor m2 , m2 muscarinic acetylcholine receptor , Muscarinic acetylcholine receptor M2 , cholinergic receptor muscarinic 2 , muscarinic acetylcholine receptor M2-like , M2 muscarinic acetylcholine receptor , cholinergic receptor, muscarinic 2, cardiac , muscarinic receptor m2 , muscarinic receptor 2

GENE ID SPECIES
1129 Homo sapiens
243764 Mus musculus
352938 Danio rerio
397498 Sus scrofa
403858 Canis lupus familiaris
418126 Gallus gallus
463758 Pan troglodytes
522170 Bos taurus
100231098 Taeniopygia guttata
100342878 Oryctolagus cuniculus
100411083 Callithrix jacchus
100450243 Pongo abelii
100593190 Nomascus leucogenys
81645 Rattus norvegicus
100715343 Cavia porcellus
101102897 Ovis aries
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