anti-Cholinergic Receptor, Muscarinic 2 (CHRM2) Antibodies

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. Additionally we are shipping Muscarinic Acetylcholine Receptor M2 Kits (58) and Muscarinic Acetylcholine Receptor M2 Proteins (6) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
CHRM2 1129 P08172
CHRM2 243764 Q9ERZ4
CHRM2 81645 P10980
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Top anti-Muscarinic Acetylcholine Receptor M2 Antibodies at antibodies-online.com

Showing 10 out of 178 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IF, ELISA, WB Western blot analysis of extracts from HeLa/MCF-7 cells, using CHRM2 Antibody. The lane on the right is treated with the synthesized peptide. Immunofluorescence analysis of LOVO cells, using CHRM2 Antibody. The picture on the right is treated with the synthesized peptide. 100 μg Log in to see 2 to 3 Days
$302.50
Details
Human Rabbit Un-conjugated WB CHRM2 Antibody (Center)  western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the CHRM2 antibody detected the CHRM2 protein (arrow). Western blot analysis of CHRM2 (arrow) using rabbit polyclonal CHRM2 Antibody (Center) . 293 cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the CHRM2 gene. 400 μL Log in to see 10 to 11 Days
$324.50
Details
Mouse Goat Un-conjugated ELISA, WB Western Blot: Muscarinic Acetylcholine Receptor M2/CHRM2 Antibody [NBP2-26152] - NBP2-26152 (2ug/ml) staining of Mouse Brain lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Log in to see 7 to 9 Days
$485.88
Details
Cow Rabbit Un-conjugated IHC (p) Immunohistochemistry-Paraffin: Muscarinic Acetylcholine Receptor M2/CHRM2 Antibody [NLS1333] - IHC analysis of brain, neurons and glia using this antibody at 6 ug/ ml. Immunohistochemistry-Paraffin: Muscarinic Acetylcholine Receptor M2/CHRM2 Antibody [NLS1333] - Analysis of anti-CHRM2 / M2 antibody with human brain, glioblastoma. 0.05 mL Log in to see 10 to 13 Days
$514.63
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of rat brain membranes: 1. Anti-M2 Muscarinic Receptor antibody, (1:200). 2. Anti-M2 Muscarinic Receptor antibody, preincubated with the control fusion protein antigen. Expression of M2 Muscarinic Receptor in mouse parieto-temporal cortex sections Immunohistochemical staining of mouse parieto-temporal cortex frozen sections (non-consecutive) using Anti-Kir3.2 (GIRK2) antibody, (1:100) and Anti-M2 Muscarinic Receptor antibody, (1:100). M2 Muscarinic Receptor staining (red) was dense in layer IV, with fibers climbing to layers II-III. Kir3.2 K+ channel staining (green) was dense in layers IV and I. Overlapping expression of Kir3.2 channel and M2 muscarinic Receptor is seen in cortical layers. 50 μL Log in to see 10 to 11 Days
$678.57
Details
Mouse Rabbit Un-conjugated WB   100 μg Log in to see 4 to 6 Days
$240.00
Details
Human Rat Un-conjugated IHC, IHC (fro)   0.1 mg Log in to see 7 to 9 Days
$345.00
Details
Human Rabbit Un-conjugated IHC (p) Anti-CHRM2 antibody  ABIN1048438 IHC staining of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$484.00
Details
Bat Rabbit Un-conjugated IHC (p) Anti-CHRM2 antibody  ABIN1048439 IHC staining of human brain, neurons and glia. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. 50 μg Log in to see 7 to 9 Days
$484.00
Details
Cow Rabbit Un-conjugated IHC (p) Anti-CHRM2 antibody IHC staining of human adrenal. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1048441 dilution 10 ug/ml. Anti-CHRM2 antibody IHC staining of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody  ABIN1048441 dilution 10 ug/ml. 50 μg Log in to see 7 to 9 Days
$484.00
Details

CHRM2 Antibodies by Reactivity, Application, Clonality and Conjugate

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Top referenced anti-Muscarinic Acetylcholine Receptor M2 Antibodies

  1. Rat (Rattus) Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for WB - ABIN965894 : Zhou, Fryer, Jacoby: Structure of the human M(2) muscarinic acetylcholine receptor gene and its promoter. in Gene 2001 (PubMed)
    Show all 5 Pubmed References

  2. Human Monoclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for IHC, IHC (fro) - ABIN4336776 : Levey, Edmunds, Hersch, Wiley, Heilman: Light and electron microscopic study of m2 muscarinic acetylcholine receptor in the basal forebrain of the rat. in The Journal of comparative neurology 1995 (PubMed)
    Show all 3 Pubmed References

  3. Human Monoclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for Func, IA - ABIN2192224 : Elies, Fu, Eftekhari, Wallukat, Schulze, Granier, Hjalmarson, Hoebeke: Immunochemical and functional characterization of an agonist-like monoclonal antibody against the M2 acetylcholine receptor. in European journal of biochemistry / FEBS 1998 (PubMed)
    Show all 2 Pubmed References

  4. Dog (Canine) Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for IF (p), IHC (p) - ABIN668646 : Zhao, Xu, Yun, Zhao, Li, Gong, Yuan, Yan, Zhang, Ding, Wang, Zhang, Dong, Xiu, Yang, Liu, Xue, Li: Chronic obstructive sleep apnea causes atrial remodeling in canines: mechanisms and implications. in Basic research in cardiology 2014 (PubMed)

  5. Bat Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for IHC (p) - ABIN270607 : Yankiwski, Noonan, Neff: The C-terminal domain of the Bloom syndrome DNA helicase is essential for genomic stability. in BMC cell biology 2002 (PubMed)

  6. Cow (Bovine) Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for IHC (p) - ABIN4336774 : Strang, Renna, Amthor, Keyser: Muscarinic acetylcholine receptor localization and activation effects on ganglion response properties. in Investigative ophthalmology & visual science 2010 (PubMed)

  7. Mouse (Murine) Polyclonal Muscarinic Acetylcholine Receptor M2 Primary Antibody for ELISA, WB - ABIN4336778 : Hendershot, Bryan, Ewing, Claus, Hutchison: Preliminary evidence for associations of CHRM2 with substance use and disinhibition in adolescence. in Journal of abnormal child psychology 2011 (PubMed)

More Antibodies against Muscarinic Acetylcholine Receptor M2 Interaction Partners

Human Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. Graded activation and free energy landscapes of a muscarinic G-protein-coupled M2 receptor has been reported.

  2. With final functional experiments on six selected compounds, we confirmed four of them as new negative allosteric modulators (NAMs) and one as positive allosteric modulator of agonist-mediated response at the M2 mAChR (show CHRM3 Antibodies)

  3. Results show reduced autonomic nervous system (ANS) activity in association with the CHRM2 rs8191992 polymorphism in patients with schizophrenia on high-dose antipsychotics. CHRM2 polymorphisms may play an important role in ANS activity in patients with schizophrenia.

  4. Data suggest that levels of CHRM2 are lower in Brodmann's area 24 from subjects with mood disorders, and it is possible that signalling by that receptor is also less in this cortical region; increasing levels of CHRM2 may be involved in the mechanisms of action of mood stabilisers and tricyclic antidepressants

  5. Report a significant association between CHRM2 (rs1824024) polymorphism and disease severity, lower lung function test values, frequent exacerbations, and poor response to anti-cholinergic drugs in COPD (show ARCN1 Antibodies) patients.

  6. Inactivation of M2 AChR/NF-kappaB (show NFKB1 Antibodies) signaling axis reverses epithelial-mesenchymal transition and suppresses migration and invasion in non-small cell lung cancer.

  7. CHRM2 gene expression was dysregulated in the anterior cingulate of bipolar patients.

  8. This study demonstrated that CD4 (show CD4 Antibodies)+ and CD8 (show CD8A Antibodies)+ T cells expressed M2 and M4 muscarinic receptors which density were significantly increased in asthmatic children in comparison with controls.

  9. The expressed the fusion proteins of the muscarinic acetylcholine receptor M2 subtype with a maltose-binding protein and various G protein alpha (show GNAO1 Antibodies) subunits in Escherichia coli.

  10. CHRM2 but not CHRM1 (show CHRM1 Antibodies) or CHRM3 (show CHRM3 Antibodies) polymorphisms are associated with asthma susceptibility in Mexican patients.

Mouse (Murine) Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. The three receptor sets considered (mAChR (show CHRM3 Antibodies), AR and TrkB (show NTRK2 Antibodies) receptors) intervene in modulating the conditions of the competition between nerve endings.

  2. In the present study, the functional coupling of Gi/o protein-coupled receptors to GalR1 (show GALR1 Antibodies), and the CB1 (show CNR1 Antibodies) receptor subtype for endocannabinoids were analyzed in the 3xTg-AD mice model of Alzheimer's disease in the prodromal and advanced stages. In addition, the activity mediated by Gi/o protein-coupled M2/4 (show GSDMD Antibodies) muscarinic receptor (show CHRM5 Antibodies) subtypes was also analyzed in brain areas involved in anxiety and cognition.

  3. Muscarinic M2 receptors in the circular muscular layer of mouse ileum exert a previously undocumented function in gut (show GUSB Antibodies) motility via the regulation of gap junctions

  4. IL-17 (show IL17A Antibodies) production in the hearts of M2AChR mice is dependent on P2x7 (show P2RX7 Antibodies) expression in dilated cardiomyopathy.

  5. Expression of the M2 receptors mediating cholinergic contractile stimuli of the detrusor muscle was dysregulated in both Mras (show MRAS Antibodies)-/- males and females, although only males exhibited a urinary phenotype.

  6. These results demonstrate that M2R are dysfunctional and do not affect ACh levels in PRiMA knockout mice, likely because of down-regulation and/or loss of receptor-effector coupling.

  7. Data indicate taht m2R-RGS6 (show RGS6 Antibodies)-IKACh pathway sets heart rate variability independently from the autonomic input.

  8. M2-mediated contractions in the M3KO and WT strains were decreased by the Rho kinase (show ROCK2 Antibodies) (ROCK) inhibitor Y27632 as well as the ROCK, PKA and PKG (show PRKG1 Antibodies) inhibitor H89.

  9. M2 receptor is co-localized with VGLUT2 on intraganglionic laminar endings of esophagus.

  10. Presence of M2 mAChR (show CHRM3 Antibodies) is sufficient and necessary to mediate the carbachol-induced membrane hyperpolarization and inhibition of SpECTs in laterodorsal tegmental nucleus neurons.

Zebrafish Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. cloning, characterization and expression patterns; results suggest that the M2 mAChR (show CHRM3 Antibodies) inhibits basal heart rate in zebrafish embryo and mediates carbachol-induced bradycardia

  2. The M(2) muscarinic receptor (show CHRM5 Antibodies) plays a specific role in the initiation of hypoxic bradycardia in fish.

Pig (Porcine) Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. Data suggest that both M(2) and M(3) muscarinic receptors mediate the contraction in both pig clasp (show CLASRP Antibodies) and sling fibers similar to human clasp (show CLASRP Antibodies) and sling fibers.

Cow (Bovine) Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. The original finding was the identification and purification of a vinpocetine and muscarinic antagonist-inhibited and CaM (show KRIT1 Antibodies)-activated plasma membrane-bound PDE1A (show PDE1A Antibodies), linked to M(2)AChR.

  2. airway M(2)Rs inhibit BK channels by a dual, Gbetagamma-mediated mechanism, a direct membrane-delimited interaction, and the activation of the phospholipase C (show PLC Antibodies)/protein kinase C (show PKC Antibodies) pathway

Rabbit Cholinergic Receptor, Muscarinic 2 (CHRM2) interaction partners

  1. Data suggest that autoantibodies to beta-1 adrenergic receptor (ADRB1 (show ADRB1 Antibodies)) and muscarinic receptor M2 (CHRM2), along with elevated thyroxine (T4) levels, contribute to atrial tachyarrhythmia in Graves disease (GD); here, a rabbit model of GD is studied.

Muscarinic Acetylcholine Receptor M2 (CHRM2) Antigen Profile

Protein Summary

The muscarinic cholinergic receptors belong to a larger family of G protein-coupled receptors. The functional diversity of these receptors is defined by the binding of acetylcholine to these receptors and includes cellular responses such as adenylate cyclase inhibition, phosphoinositide degeneration, and potassium channel mediation. Muscarinic receptors influence many effects of acetylcholine in the central and peripheral nervous system. The muscarinic cholinergic receptor 2 is involved in mediation of bradycardia and a decrease in cardiac contractility. Multiple alternatively spliced transcript variants have been described for this gene.

Gene names and symbols associated with CHRM2

  • cholinergic receptor muscarinic 2 (CHRM2) antibody
  • cholinergic receptor, muscarinic 2, cardiac (Chrm2) antibody
  • cholinergic receptor, muscarinic 2a (chrm2a) antibody
  • cholinergic receptor, muscarinic 2 (Chrm2) antibody
  • cholinergic receptor muscarinic 2 (Chrm2) antibody
  • AChR-M2 antibody
  • Acm2 antibody
  • Chrm-2 antibody
  • chrm2 antibody
  • GPM2 antibody
  • HM2 antibody
  • M2 antibody

Protein level used designations for CHRM2

7TM receptor , acetylcholine receptor, muscarinic 2 , muscarinic M2 receptor , muscarinic acetylcholine receptor M2 , AChR M2 , muscarinic acetylcholine receptor 2 , cholinergic receptor, muscarinic 2 , cardiac muscarinic acetylcholine receptor , muscarinic acetylcholine receptor m2 , m2 muscarinic acetylcholine receptor , Muscarinic acetylcholine receptor M2 , cholinergic receptor muscarinic 2 , muscarinic acetylcholine receptor M2-like , M2 muscarinic acetylcholine receptor , cholinergic receptor, muscarinic 2, cardiac , muscarinic receptor m2 , muscarinic receptor 2

GENE ID SPECIES
1129 Homo sapiens
243764 Mus musculus
352938 Danio rerio
397498 Sus scrofa
403858 Canis lupus familiaris
418126 Gallus gallus
463758 Pan troglodytes
522170 Bos taurus
100231098 Taeniopygia guttata
100342878 Oryctolagus cuniculus
100411083 Callithrix jacchus
100450243 Pongo abelii
100593190 Nomascus leucogenys
81645 Rattus norvegicus
100715343 Cavia porcellus
101102897 Ovis aries
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