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CCBE1 encodes a protein containing an emilin domain and two collagen stretches.
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these data indicated that CCBE1 may be served as a new predictor of prognosis in post-operative gastrointestinal stromal tumor patients and may play an important role in stimulating tumor progression
We identify CCBE1 as a direct target of miR (show MLXIP Antibodies)-330-3p, and show that knockdown of CCBE1 results in a greater invasive capacity. Accordingly, in breast cancer patients CCBE1 is frequently downregulated, and its loss is associated with reduced distant relapse-free and overall survival.
Collagen domains of CCBE1 are crucial for the activation of VEGFC (show VEGFC Antibodies) in vitro and in vivo. The EGF (show EGF Antibodies) domains of CCBE1 are dispensable for regulation of VEGFC (show VEGFC Antibodies) processing in vitro, however, they are necessary for full lymphangiogenic activity of CCBE1 in vivo.
CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease with thrombospondin motifs-3-mediated vascular endothelial growth factor-C (show VEGFC Antibodies) activation.
Both siblings harbored a homozygous mutation in CCBE1.
The study has shown that CCBE1 mutations are not a major contributor to non-immune hydrops fetalis.
Human CCBE1 strongly enhances vascular endothelial growth factor-C-mediated lymphangiogenesis in a corneal micropocket assay
Loss of CCBE1 expression may promote ovarian carcinogenesis by enhancing migration & cell survival. CCBE1 is a new candidate tumour suppressor in ovarian cancer.
Homozygous cysteine to serine change and SNPS in CCBE1 were identified patients.
Mutations in CCBE1 cause generalized lymph vessel dysplasia in humans
CCBE1 enhances lymphangiogenesis via A disintegrin and metalloprotease (show ADAMTS7 Antibodies) with thrombospondin motifs-3-mediated vascular endothelial growth factor-C (show VEGFC Antibodies) activation.
Ccbe1 has an essential role in lymphangiogenesis [review]
The secreted lymphangiogenic protein CCBE1 is essential for fetal but not postnatal erythropoiesis.
Ccbe1 expression marks the cardiac and lymphatic progenitor lineages during early stages of mouse development
Phenotypic analysis of murine Ccbe1 mutant embryos show a complete lack of definitive lymphatic structures, even though lymphatic endothelial cells are specified within the cardinal (show CARD8 Antibodies) vein
In the embryo, phenotypes driven by increased Vegfc (show VEGFC Antibodies) are suppressed in the absence of Ccbe1, and Vegfc (show VEGFC Antibodies)-driven sprouting is enhanced by local Ccbe1 overexpression. Moreover, Vegfc (show VEGFC Antibodies)- and Vegfr3 (show FLT4 Antibodies)-dependent Erk (show MAPK1 Antibodies) signaling is impaired in the absence of Ccbe1.
This gene is thought to function in extracellular matrix remodeling and migration. It is predominantly expressed in the ovary, but down regulated in ovarian cancer cell lines and primary carcinomas, suggesting its role as a tumour suppressor. Mutations in this gene have been associated with Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymphatic dysplasia in humans.
collagen and calcium-binding EGF domain-containing protein 1
, full of fluid protein homolog
, collagen and calcium binding EGF domains 1
, full of fluid protein
, LOW QUALITY PROTEIN: collagen and calcium-binding EGF domain-containing protein 1