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CFHR1 encodes a secreted protein belonging to the complement factor H protein family. Additionally we are shipping CFHR1 Antibodies (45) and CFHR1 Kits (14) and many more products for this protein.
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To our knowledge, this is the first evaluation of the involvement of the CFHR3/CFHR1 deletion and age-related macular degeneration in CFH (show CFH Proteins) Y402H polymorphism Brazilian patients.
These results identify C-reactive protein (show CRP Proteins) as a ligand for FHR-1 and suggest that FHR-1 enhances, rather than inhibits, complement activation, which may explain the protective effect of FHR-1 deficiency in age-related macular degeneration.
The CFHR1 level in plasma of T2DM patients were significantly higher than that of the healthy controls.
CFHL-1 is a CFH (show CFH Proteins) gene splice variant.
We investigated whether the causal sequence variant resides in the CFH (show CFH Proteins) gene or the neighboring complement factor H-related 1 (CFHR1) gene, and fine mapping Implicates a deletion of CFHR1 in protection from IgA nephropathy in Han Chinese
Next-generation sequencing of the CFH (show CFH Proteins) region identified putatively functional variants (missense, splice site and indel) on the four common haplotypes. We found no expression of any of the five CFH (show CFH Proteins)-related genes in the retina or RPE (show RPE Proteins)/Choroid/Sclera, in contrast to the liver, which is the main source of the circulating proteins. [CFHR1]
Studies indicate that complement factor H (show CFH Proteins)-related proteins (FHR1-5) may enhance complement activation, with important implications for the role of these proteins in disease.
These results suggest that the combination of quantitative and qualitative variations in the complement proteins encoded by CFH (show CFH Proteins), CFHR3 and CFHR1 genes is key for the association of these haplotypes with disease.
Genetic variants in CFH, CFHR3, and CFHR1 affect complement activation and thereby predispose patients to develop IgA nephropathy.
An average of 15.2% of factor H (show CFH Proteins)-autoantibody positive individuals with rheumatic diseases or hemolytic uremic syndrome had homozygous deficiency of CFHR1.
This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome.
complement component factor h-like 1
, complement factor H-related protein
, complement factor H-related protein 1
, complement factor H-related 1
, H factor (complement)-like 1
, H factor (complement)-like 2
, H-factor-like 1
, complement factor H-related 1 pseudogene
, h factor-like protein 1