Core 1 Synthase, Glycoprotein-N-Acetylgalactosamine 3-beta-Galactosyltransferase, 1 Proteins (C1GALT1)

The protein encoded by C1GALT1 generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R.

list all proteins Gene Name GeneID UniProt
Human C1GALT1 C1GALT1 56913 Q9NS00
Mouse C1GALT1 C1GALT1 94192 Q9JJ06
Rat C1GALT1 C1GALT1 65044 Q9JJ05
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Top Core 1 Synthase, Glycoprotein-N-Acetylgalactosamine 3-beta-Galactosyltransferase, 1 Proteins at antibodies-online.com

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Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg Log in to see 50 to 55 Days
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Insect Cells Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Log in to see 50 Days
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Wheat germ Human GST tag 10 μg Log in to see 11 to 12 Days
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Yeast Xenopus laevis His tag   1 mg Log in to see 60 to 71 Days
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Escherichia coli (E. coli) Human His tag   50 μg Log in to see 13 to 16 Days
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More Proteins for Core 1 Synthase, Glycoprotein-N-Acetylgalactosamine 3-beta-Galactosyltransferase, 1 (C1GALT1) Interaction Partners

Human Core 1 Synthase, Glycoprotein-N-Acetylgalactosamine 3-beta-Galactosyltransferase, 1 (C1GALT1) interaction partners

  1. There was no relationship between rs1047763 and rs1008898 C1GALT1 polymorphisms and susceptibility to IgA nephropathy. (Meta-analysis)

  2. C1GALT1 modifies O-glycan expression and enhances malignant behaviors in ovarian cancer cells, suggesting that C1GALT1 plays a role in the pathogenesis of ovarian cancer.

  3. These findings demonstrate that common variation at C1GALT1 influences Gd-IgA1 level in the population, which independently associates with risk of progressive IgA nephropathy, and that the pathogenic importance of changes in IgA1 O-glycosylation may vary between white and Chinese patients with IgA nephropathy

  4. Polymorphisms near C1galt1 (rs10486157) and its molecular chaperone, Cosmc (rs4825729), were associated with altered composition of (show SLC13A2 Proteins) the colonic mucosal microbiota in Crohn's disease patients.

  5. Data indicate that mRNA levels of both core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase (show GGTA1 Proteins), 1 (C1GALT1) and C1GALT1-specific chaperone 1 (show C1GALT1C1 Proteins) protein (C1GALT1C1 (show C1GALT1C1 Proteins)) determine the rate of secretion of galactose-deficient IgA1 (Gd-IgA1) in IgA1-producing cells.

  6. The terminal glycosylation of secreted IgA1 was altered in response to TGFbeta1 (show TGFB1 Proteins). TGFbeta1 (show TGFB1 Proteins) stimulation significantly decreased the mRNA levels of C1GalT1 and Cosmc (show C1GALT1C1 Proteins). TGFbeta1 (show TGFB1 Proteins) may be key in controlling the glycosylation of IgA1, in part via the downregulation of C1GalT1 and Cosmc (show C1GALT1C1 Proteins).

  7. There was no statistically significant difference between the two groups (P > 0.05). The rs1047763 SNP of the C1GALT1 gene probably has no correlation with genetic susceptibility to IgAN in Xinjiang Uyghur people.

  8. Polymorphisms in the C1GALT1 gene were associated with genetic susceptibility to Uyghur Immunoglobulin A (IgA) nephropathy.

  9. Overexpression of C1GALT1 enhanced breast cancer cell growth, migration, and invasion in vitro as well as tumor growth in vivo.

  10. C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin beta1 glycosylation and activity.

Mouse (Murine) Core 1 Synthase, Glycoprotein-N-Acetylgalactosamine 3-beta-Galactosyltransferase, 1 (C1GALT1) interaction partners

  1. hepatic asialoglycoprotein receptor promotes preferential adherence to and phagocytosis of desialylated and/or HC C1galt1(-/-) platelets by the Kupffer cell through its C-type lectin receptor (show CLEC4D Proteins) CLEC4F (show CLEC4F Proteins). These findings provide insights into an essential role for core 1 O-glycosylation of platelets in their clearance in the liver.

  2. Deletion of C1galt1 in mice develop spontaneous microbiota-dependent colitis with a remitting/relapsing course due to loss of mucin (show SLC13A2 Proteins) core-1 derived O-glycans.

  3. C1GALT1 promotes invasive phenotypes of hepatocellular carcinoma cells by modulating integrin beta1 glycosylation and activity.

  4. O-glycan is required for terminal megakaryocyte differentiation and platelet production and the decrease in GPIbalpha (show GP1BA Proteins) in cells lacking O-glycan might be caused by increased proteolysis.

  5. Data from transgenic mice suggest that a lack of complex N- and O-glycans impairs early embryo development and viability in vivo leading to delayed implantation and embryo loss; C1galt1 and MGAT1 (show MGAT1 Proteins) are required for embryo development and implantation.

  6. disease in plt1/plt1 mice suggests that, in addition to immune-mediated effects, intrinsic C1Gal-T1 deficiency in megakaryocytes and the kidney may contribute to pathology

  7. Transgenic mice were generated lacking T-synthase (C1galt1).

Core 1 Synthase, Glycoprotein-N-Acetylgalactosamine 3-beta-Galactosyltransferase, 1 (C1GALT1) Protein Profile

Protein Summary

The protein encoded by this gene generates the common core 1 O-glycan structure, Gal-beta-1-3GalNAc-R, by the transfer of Gal from UDP-Gal to GalNAc-alpha-1-R. Core 1 is a precursor for many extended mucin-type O-glycans on cell surface and secreted glycoproteins. Studies in mice suggest that this gene plays a key role in thrombopoiesis and kidney homeostasis.

Gene names and symbols associated with C1GALT1

  • core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 (C1GALT1)
  • core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1b (c1galt1b)
  • core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 (C1galt1)
  • glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 L homeolog (LOC100496837.L)
  • 2210410E06Rik protein
  • AV284120 protein
  • C1GALT protein
  • C1GALT1 protein
  • fa98f05 protein
  • T-synthase protein
  • wu:fa98f05 protein
  • zgc:66485 protein

Protein level used designations for C1GALT1

C1GalT1-B , core 1 O-glycan T-synthase B , core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1-B , core 1 beta1,3-galactosyltransferase 1-B , core 1 beta3-Gal-T-B , core 1 beta3-Gal-T1-B , core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase, 1 , core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1-B , glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-B , glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1-like , B3Gal-T8 , core 1 O-glycan T-synthase , core 1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1 , core 1 beta3-Gal-T1 , glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1 , T-syn , core 1 beta1,3-galactosyltransferase 1 , core 1 beta3-Gal-T , core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase 1 , core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galactosyltransferase (C1galt1) , core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 13-galactosyltransferase (C1galt1) , core1 UDP-galactose:N-acetylgalactosamine-alpha-R beta 1,3-galac

GENE ID SPECIES
482314 Canis lupus familiaris
337131 Danio rerio
472288 Pan troglodytes
100406487 Callithrix jacchus
100483848 Ailuropoda melanoleuca
56913 Homo sapiens
94192 Mus musculus
65044 Rattus norvegicus
539417 Bos taurus
420575 Gallus gallus
444326 Xenopus laevis
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