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DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA.
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Different charge distributions along the DNA binding groove may account for the drastic difference in processivity and DNA digestion efficiency, including that of damaged substrates, between SNM1A and SNM1B.
The SNM1B/APOLLO DNA nuclease (show DCLRE1C Proteins) functions in resolution of replication stress and maintenance of common fragile site stability.
the N-terminal region of Snm1B forms a complex containing PSF2 (show TAP2 Proteins) and Mus81 (show MUS81 Proteins), while the C-terminal region is important for PSF2 (show TAP2 Proteins)-mediated chromatin association.
The nuclease hSNM1B/Apollo is linked to the Fanconi anemia pathway via its interaction with FANCP/SLX4.
differences in the substrate selectivities of SNM1A and SNM1B are likely to be relevant to their in vivo roles
SNM1B functions epistatically to the central Fanconi anemia factor, FANCD2, in cellular survival after interstrand crosslinks damage and homology-directed repair of DNA double-strand breaks
TRF2 (show TERF2 Proteins), which binds preferentially to positively supercoiled DNA substrates, together with Apollo, negatively regulates the amount of TOP1 (show TOP1 Proteins), TOP2alpha, and TOP2beta (show TOP2B Proteins) at telomeres.
siRNA knockdown of hSNM1B rendered cells sensitive to ionizing radiation, suggesting the possibility of hSNM1B involvement in homologous recombination repair of double-strand breaks arising as intermediates of ICL repair
the C terminus of Snm1B was shown to interact with the TRF (show IL5 Proteins) homology domain of TRF2 (show TERF2 Proteins) indicating that Snm1B is likely recruited to the telomere via interaction with the double-stranded telomere-binding protein TRF2 (show TERF2 Proteins)
SNM1B (Apollo) protein exhibits a 5'-to-3' DNA exonuclease (show EXO1 Proteins) activity and functions together with TRF2 (show TERF2 Proteins) to protect telomeres from damage and fusion.
Study documents the combinatorial action of Apollo, POT1b, CST (show CORT Proteins), and the 5' exonuclease (show EXO1 Proteins) Exo1 (show EXO1 Proteins) in postreplicative telomere end processing in mouse cells, clarifying the mechanism by which the telomeric 3' overhang is generated and modulated.
The telomeric protein (show SYCE1 Proteins) SNM1B/Apollo is required for normal cell proliferation and embryonic development
TRF2 (show TERF2 Proteins)-bound Apollo functions at replicating telomeres, promoting the maintenance of the telomeric overhang, repressing S phase-specific ATM (show ATM Proteins) signaling, and protecting leading-end telomeres from fusion.
Apollo null mouse embryo fibroblasts exhibit an increased incidence of G2 chromatid-type fusions involving telomeres created by leading-strand DNA synthesis, reflective of a failure to protect these telomeres after DNA replication.
DNA interstrand cross-links prevent strand separation, thereby physically blocking transcription, replication, and segregation of DNA. DCLRE1B is one of several evolutionarily conserved genes involved in repair of interstrand cross-links (Dronkert et al., 2000
5' exonuclease Apollo
, DNA cross-link repair 1B (PSO2 homolog, S. cerevisiae)
, PSO2 homolog
, SNM1 homolog B
, DNA cross-link repair 1B protein