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DPH5 encodes a component of the diphthamide synthesis pathway. Additionally we are shipping DPH5 Antibodies (6) and many more products for this protein.
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This gene encodes a component of the diphthamide synthesis pathway. Diphthamide is a post-translationally modified histidine residue found only on translation elongation factor 2. It is conserved from archaebacteria to humans, and is targeted by diphtheria toxin and Pseudomonas exotoxin A to halt cellular protein synthesis. The yeast and Chinese hamster homologs of this protein catalyze the trimethylation of the histidine residue on elongation factor 2, resulting in a diphthine moiety that is subsequently amidated to yield diphthamide. Multiple transcript variants encoding different isoforms have been found for this gene.
, diphthamide biosynthesis methyltransferase
, diphthine synthase
, protein x 0011