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Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Additionally we are shipping Desmoglein 3 Antibodies (175) and Desmoglein 3 Kits (17) and many more products for this protein.
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our findings suggest that Dsg3 functions as a key in cell-cell adhesion through at least a mechanism of regulating E-cadherin (show CDH1 Proteins) membrane trafficking
Desmoglein 3 Order and Dynamics in Desmosomes
Data indicate that all 3 monoclonal antibodies (mAbs) targeted the same extracellular cadherin (EC) domain on desmoglein 3 (Dsg3), caused Dsg3 internalization in primary keratinocytes, and caused suprabasal blisters in skin.
DSG3 was a key prognostic factor and predictor for neoadjuvant concurrent chemoradiotherapy response in rectal cancer patients.
Treg cells exert a clear down-regulatory effect on the Dsg3-driven T-cell response and, accordingly, the formation of Dsg3-specific IgG antibodies
Data identify DSG3 as a negative prognostic biomarker in resected pancreatic ductal adenocarcinoma, as high DSG3 expression is associated with poor overall survival and poor tumour-specific survival.
this study directly demonstrates the occurrence of desmoglein 3 molecules outside of desmosomes and reveales that the adhesive properties of these molecules do differ depending on their localization.
DSG2 (show DSG2 Proteins) and DSG3 might be potential diagnostic markers for squamous cell carcinoma of the lung and DSG3 could be a potential differentiation marker for lung cancer.
alterations of their expression suggest a role of Dsg3 and gamma-catenin (show JUP Proteins) (additionally to E-cadherin (show CDH1 Proteins)/beta-catenin (show CTNNB1 Proteins)) as biomarkers of malignant transformation risk of oral dysplasia and the biological behavior (aggressiveness) of oral cancer, respectively
In endometrial luminal epithelium, cadherin 6 (show CDH6 Proteins), desmoglein 2 (show DSG2 Proteins) and plexin b2 (show PLXNB2 Proteins) were surprisingly found in the apical as well as the lateral membrane domain; their knock-down compromised epithelial integrity.
Desmoglein 3 deficiency in mice leads to a phenotype characterized by cyclic alopecia in addition to the dramatic skin and mucocutaneous acantholysis observed in pemphigus patients.
Dsg3, via p38 MAPK (show MAPK14 Proteins), regulates the spatial distribution of the keratin filament network and stabilizes cell adhesion.
Squamous metaplasia after pulmonary epithelial injury may play a crucial role in redirecting the skin-specific autoimmune reaction to the lungs in paraneoplastic pemphigus (PNP (show NP Proteins)).
Dsg3 deficiency results in perturbation of the desmosomal network at the transcriptional, translational, and interaction level, kinase activation, proteinase-mediated degradation, and hyper-adhesion. (Review)
Thus, Dsg3 does not display a clear function as a tumor suppressor in these mouse skin cancer models
IgG and IgM (show CD40LG Proteins) antibodies against desmoglein 3 have a pathogenic role in blister formation in pemphigus vulgaris
the adult passive transfer mouse model is ideally suited for detailed studies of Dsg3 antibody-mediated signaling in adult skin.
These data indicate a contribution of Dsg (show DSG1 Proteins) depletion to pemphigus vulgaris pathogenesis dependent on Ca(2 (show CA2 Proteins)+)-induced differentiation.
Transgenic expression of Dsg1 (show DSG1 Proteins) rescued the severe B6-Dsg3(-/-) phenotype and provided a syngeneic mouse model of pemphigus vulgaris.
Aire (show AIRE Proteins) has an important role in Dsg3 expression as well as in selection of T cells that help B cells to produce anti-Dsg3 IgG in thymus.
Desmosomes are cell-cell junctions between epithelial, myocardial, and certain other cell types. Desmoglein 3 is a calcium-binding transmembrane glycoprotein component of desmosomes in vertebrate epithelial cells. Currently, three desmoglein subfamily members have been identified and all are members of the cadherin cell adhesion molecule superfamily. These desmoglein gene family members are located in a cluster on chromosome 18. This protein has been identified as the autoantigen of the autoimmune skin blistering disease pemphigus vulgaris.
desmoglein 3 (pemphigus vulgaris antigen)
, desmoglein 3
, 130 kDa pemphigus vulgaris antigen
, 130-kD pemphigus vulgaris antigen
, cadherin family member 6
, pemphigus vulgaris antigen
, 130 kDa pemphigus vulgaris antigen homolog
, desmoglein 3 preprotein