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DGAT2 encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs.
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Human Polyclonal DGAT2 Primary Antibody for EIA, IHC (p) - ABIN252916
Beaudoin, Snook, Arkell, Stefanson, Wan, Simpson, Holloway, Wright: Novel effects of rosiglitazone on SMAD2 and SMAD3 signaling in white adipose tissue of diabetic rats. in Obesity (Silver Spring, Md.) 2014
Show all 2 Pubmed References
Human Polyclonal DGAT2 Primary Antibody for WB - ABIN4305106
Paland, Gamliel-Lazarovich, Coleman, Fuhrman: Urokinase-type plasminogen activator (uPA) stimulates triglyceride synthesis in Huh7 hepatoma cells via p38-dependent upregulation of DGAT2. in Atherosclerosis 2014
Show all 2 Pubmed References
Human Polyclonal DGAT2 Primary Antibody for ICC, IF - ABIN443031
Oh, Oh, Choi, Jokiaho, Donovan, Choi, Kang, Youn: Continuous 24-h nicotinic acid infusion in rats causes FFA rebound and insulin resistance by altering gene expression and basal lipolysis in adipose tissue. in American journal of physiology. Endocrinology and metabolism 2011
We first report loss-of-function mutations in DGAT2 and FAAH (show FAAH Antibodies) in one obese subject, which may interact with each other to affect the adiposity penetrance, providing a model of genetic interaction associated with human obesity.
The findings indicate the functionality of the prostate cancer death-predisposing SNPs rs143975731, rs12277366, rs2155225, and rs2155222 as DGAT2 regulators in prostate tumors.
Diacylglycerol acyltransferase-2 (show AWAT1 Antibodies) and monoacylglycerol acyltransferase-2 are ubiquitinated proteins that are degraded by the 26S proteasome (show Psmd4 Antibodies)
Results identified a novel de novo p.Y223H mutation in the DGAT2 from an autosomal-dominant Korean Charcot-Marie-Tooth (CMT) family suggesting this mutation a novel underlying cause of an autosomal-dominant CMT2 phenotype.
uPA (show PRAP1 Antibodies)/uPAR (show PLAUR Antibodies) stimulates triglyceride synthesis in Huh7 hepatoma cells via p38 (show CRK Antibodies)-dependent upregulation of DGAT2
DGAT2 is regulated by gp78 (show AMFR Antibodies)-associated endoplasmic-reticulum-associated degradation at the post-translational level.
Hepatic triacylglycerol synthesis and secretion: DGAT2 as the link between glycaemia and triglyceridaemia.
describe distinct but synergistic roles of the two DGATs in an integrated pathway of TAG synthesis and secretion, with DGAT2 acting upstream of DGAT1 (show DGAT1 Antibodies)
Niacin treatment may reduce liver fat content in Chinese patients with dyslipidemia and the mechanism may involve inhibition of DGAT2.
DGAT2 expression is decreased in psoriatic skin.
Data showed the associations between SNPs in intron 6 and intron 7 of the bovine diacylglycerolacyltransferase (show DGAT1 Antibodies) (DGAT2) gene and growth traits in purebred Nanyang cattle.
Study on the polymorphisms of DGAT2 gene in 92 Jiaxian red cattle show that genotype AB may have positive effect on body weight.
These results suggest that the 13bp indel polymorphism in the 3'-UTR (show UTS2R Antibodies) of porcine DGAT2 most likely affects fat deposition by altering its expression in pigs.
The porcine CTNNBL1 (show CTNNBL1 Antibodies) and DGAT2 genes affect porcine fat deposition and further investigation will be necessary to illustrate the underlying mechanisms.
DGAT1 (show DGAT1 Antibodies) does not contribute to this pathway, but uses exogenous FA and glycerol to synthesize a functionally distinct pool of TAG to which DGAT2 also contributes...in b3-agonist activated brown adipocytes, DGAT2 specifically enables channelling of de novo synthesized FA into a rapidly mobilized pool of TAG, which is simultaneously hydrolyzed to provide substrates for mitochondrial fatty acid oxidation.
these results support a model where Dgat1 (show DGAT1 Antibodies) and Dgat2 function coordinately to regulate the process of dietary fat absorption by preferentially synthesizing TAG for incorporation into distinct subcellular TAG pools in enterocytes.
when intestinal DGAT2 is present in excess (show RCC1 Antibodies), mRNA levels of genes involved in fatty acid oxidation were reduced. This result suggests that reduced fatty acid oxidation may contribute to increased TG secretion by overexpression of DGAT2 in intestine
role of Mtp (show LAPTM4A Antibodies) and DGAT2 in hepatic steatosis
DGAT2 is capable of catalyzing TG synthesis and promote its storage in cytosolic lipid droplets independent of its localization in the ER.
DAG-induced PKCepsilon (show PRKCE Antibodies) activation plays a major role in nonalcoholic fatty liver disease (NAFLD (show TSC2 Antibodies))-associated hepatic insulin (show INS Antibodies) resistance.
Findings show that DGAT1 and DGAT2 account for the vast majority of TG synthesis in mice, and DGAT function is required for LDs in adipocytes, but not in all cell types.
upregulation of DGAT2 plays an important role in the pathogenesis of alcoholic fatty liver disease
the increased rate of hepatic TAG secretion and intracellular accumulation in ob/ob mice is accompanied by parallel increases in the activities of both DGAT I and DGAT II
DGAT2 expression is increased in diabetic mice.
expression of a codon-optimized version of the DGAT2 gene is able to restore neutral lipid accumulation in the Saccharomyces cerevisiae mutant strain
Using immunogold technique, DGAT2 found in lipid bodies associated with microtubules; microtubules may participate in lipid biosynthesis as indicated by the presence of DGAT2. [DGAT2]
This gene encodes one of two enzymes which catalyzes the final reaction in the synthesis of triglycerides in which diacylglycerol is covalently bound to long chain fatty acyl-CoAs. The encoded protein catalyzes this reaction at low concentrations of magnesium chloride while the other enzyme has high activity at high concentrations of magnesium chloride. Multiple transcript variants encoding different isoforms have been found for this gene.
acyl-CoA retinol O-fatty-acyltransferase
, diacylglycerol O-acyltransferase homolog 2
, diacylglycerol O-acyltransferase-like protein 2
, diglyceride acyltransferase 2
, retinol O-fatty-acyltransferase
, putative diacylglycerol O-acyltransferase
, diacylglycerol acytransferase 2
, diacylglycerol acyltransferase 2
, diacylglycerol O-acyltransferase 2