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binds neuronal cell guanylate kinase PSD-95/SAP90\; may play a role in post synaptic density structure and synaptic function [RGD, Feb 2006].. Additionally we are shipping and and many more products for this protein.
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Human Polyclonal DLGAP3 Primary Antibody for IHC, ELISA - ABIN1003105
Takeuchi, Hata, Hirao, Toyoda, Irie, Takai: SAPAPs. A family of PSD-95/SAP90-associated proteins localized at postsynaptic density. in The Journal of biological chemistry 1997
Show all 4 Pubmed References
several rare variants of the DLGAP3 gene were found in this study which may be associated with schizophrenia.
This study provides suggestive evidence that DLGAP3 and its interactive effect with SLC1A1 (show SLC1A1 Antibodies) might be involved in susceptibility to developing OC symptoms in schizophrenia patients receiving AAP (show APEH Antibodies) treatment.
This study generated preliminary evidence to link SAPAP3 variants to the development of earlier onset obsessive-compulsive disorder.
DLGAP3 remains a promising candidate gene for Tourette Syndrome.
Sapap3 is a promising functional candidate gene for human grooming disorder (obsessive compulsive disorder).
Multiple rare SAPAP3 missense variants in trichotillomania and OCD.
Recorded ultrasonic vocalizations (USVs) from 5-day-old sapap3 and sapap3 mice, and also monitored developmental reflexes in these mice during the early postnatal period. Sapap3 mice display an increase in the number and duration of USV calls relative to sapap3 littermates, despite otherwise similar developmental profiles.
Both constitutive and induced genetic deletion of the melanocortin 4 receptor (show MC4R Antibodies) gene(MC4R (show MC4R Antibodies)) normalizes compulsive grooming and striatal electrophysiologic impairments in SAPAP3-null mice
These results identify a role for SAPAP3 in the regulation of postsynaptic metabotropic glutamate (show GRIN1 Antibodies) receptors and endocannabinoid-mediated synaptic plasticity.
Semi-quantitative analysis of RNA levels in FMRP (show FMR1 Antibodies) immunoprecipitates showed that in the mouse brain mRNAs encoding PSD (show PSD Antibodies) components, such as Shank1 (show SHANK1 Antibodies), SAPAP1 (show DLGAP1 Antibodies)-3, PSD-95 (show DLG4 Antibodies), and the glutamate (show GRIN1 Antibodies) receptor subunits NR1 (show GRIN1 Antibodies) and NR2B (show GRIN2B Antibodies), are associated with FMRP (show FMR1 Antibodies).
binds neuronal cell guanylate kinase PSD-95/SAP90\; may play a role in post synaptic density structure and synaptic function
, PSD-95/SAP90-binding protein 3
, SAP90/PSD 95 associated protein 3
, SAP90/PSD-95-associated protein 3
, disks large-associated protein 3
, prion protein ligand 8
, PSD-95/SAP90-associated protein-3
, discs, large (Drosophila) homolog-associated protein 3
, discs, large homolog-associated protein 3