DLG3 encodes a member of the phosphoinositide phospholipase C beta enzyme family that catalyze the production of the secondary messengers diacylglycerol and inositol 1,4,5-triphosphate from phosphatidylinositol in G-protein-linked receptor-mediated signal transduction.
This gene encodes a member of the membrane-associated guanylate kinase protein family. The encoded protein may play a role in clustering of NMDA receptors at excitatory synapses. It may also negatively regulate cell proliferation through interaction with the C-terminal region of the adenomatosis polyposis coli tumor suppressor protein. Mutations in this gene have been associated with X-linked mental retardation. Alternatively spliced transcript variants have been described.
Gene names and symbols associated with DLG3
discs large MAGUK scaffold protein 3 (DLG3) antibody
discs, large homolog 3 (Drosophila) (dlg3) antibody
discs, large homolog 3 (Drosophila) (Dlg3) antibody
discs large MAGUK scaffold protein 3 (Dlg3) antibody
Protein level used designations for DLG3
disks large homolog 3
, synapse-associated protein 102
, discs large homolog 3
, discs, large homolog 3 (neuroendocrine-dlg, Drosophila)
, membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)
, PSD-95/SAP90-related protein 1