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The protein encoded by DOK1 is part of a signal transduction pathway downstream of receptor tyrosine kinases. Additionally we are shipping DOK1 Antibodies (231) and DOK1 Proteins (9) and many more products for this protein.
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Taken together, these results indicate that ATRA-enhanced expression of DOK1 activates PPARgamma (show PPARG ELISA Kits) leading to inhibition of cell proliferation and enhancement of cell apoptosis in MCF-7 cell.
DOK1 was identified as a prognostic factor for non-metastatic CRC (show CALR ELISA Kits), and, via its drugability by PPARgamma (show PPARG ELISA Kits)-agonist, may constitute a potential target for future cancer treatments.
DOK3 expression was not altered much in HTLV-1-infected T cells.
Results indicate that hypermethylation of tumor suppressor protein (show TP53 ELISA Kits) RASSF1A (show RASSF1 ELISA Kits) and docking protein 1 (DOK1) contributes to hepatocarcinogenesis and is associated to clinicopathological characteristics.
Data show that residues Ser745 and Ser756 in the integrin beta2 tail, which are adjacent to the NxxF motif, are required for docking protein 1, docking protein 1, 62kDa (show GTF2H1 ELISA Kits) (downstream of tyrosine kinase 1) (Dok1) interaction.
results support a model in which Dok1 phosphorylation normally suppresses localized Ras pathway activity in Crk (show CRK ELISA Kits)-transformed cells via recruitment and/or activation of RasGAP (show RASA1 ELISA Kits)
Data implicate existence of alternate conformational states around the ligand binding pocket of the PTB (show PTBP1 ELISA Kits) domain of phosphoprotien Dok1 either in the native or in the near native conditions.
Deregulation of DOK1 gene expression by EBV and novel insights into the regulation of the DOK1 tumor suppressor in viral-related carcinogenesis.
point mutations in DOK1 and DOK2 genes are detected with low frequency in chronic myelomonocytic leukemia but may have consequences for the function of the DOK2 PTB (show PTBP1 ELISA Kits) domain
A crucial role for DOK1 in the regulation of PDGF-BB-mediated tumour cell motility through a p130Cas-Rap1 signalling pathway.
findings demonstrate that Dok-3 and Dok-1/-2 play distinctive but cooperative roles in osteoclastogenesis and protect mice from osteopenia, providing physiological and pathophysiological insight into bone homeostasis.
Platelets from Dok-1-/- mice displayed normal aggregation, activation of integrin alphaIIbbeta3, P-selectin (show SELP ELISA Kits) surface expression, and soluble fibrinogen binding. These findings indicate that Dok-1 does not affect "inside-out" platelet signalling.
in the absence of PAG, Csk becomes more associated with alternative partners; i.e., phosphatase PTPN22 and Dok adaptors. Combining PAG deficiency with PTPN22 or Dok adaptor deficiency further enhances effector T cell responses. Unlike PAG, Cbl ubiquitin ligases inhibit the activation of naive, but not of effector, T cells.
These results reveal the critical involvement of Dok-1 and Dok-2 in a negative-feedback loop that prevents overactivation of CD8 (show CD8A ELISA Kits)(+) T cells and promotes memory formation.
Thus, Dok-1 and Dok-2 promote survival of glycoprotein B-specific CD8 (show CD8A ELISA Kits)(+) T cells in trigeminal ganglia latently infected with herpes simplex virus 1.
this study shows that Dok1 and Dok2 proteins are involved in the control of hematopoietic stem cell cycle regulation
Taken together, our results demonstrate that Dok-1 and Dok-2 negatively regulate intestinal inflammation, apparently through the induction of IL-17A (show IL17A ELISA Kits) and IL-22 (show IL22 ELISA Kits) expression.
Dok1 knockdown attenuated TLR2-induced NF-kappaB (show NFKB1 ELISA Kits) activation and IL-6 (show IL6 ELISA Kits) production in microglia.
Triple Dok1 Doc2 Doc3 knockout leads to spontaneous pulmonary inflammation with hallmarks of asthma.
Dok-1 overexpression promotes the generation of an innate-like CD8 (show CD8A ELISA Kits)(+) T-cell population that expresses Eomesodermin (show EOMES ELISA Kits).
The protein encoded by this gene is part of a signal transduction pathway downstream of receptor tyrosine kinases. The encoded protein is a scaffold protein that helps form a platform for the assembly of multiprotein signaling complexes. Two transcript variants encoding different isoforms have been found for this gene.
Downstream of tyrosine kinase 1
, docking protein 1
, docking protein 1 (downstream of tyrosine kinase 1)
, downstream of tyrosine kinase 1
, downstream of tyrosine kinase-1