Duffy Blood Group, Chemokine Receptor Proteins (DARC)

The protein encoded by DARC is a glycosylated membrane protein and a non-specific receptor for several chemokines. Additionally we are shipping DARC Antibodies (116) and DARC Kits (5) and many more products for this protein.

list all proteins Gene Name GeneID UniProt
DARC 2532 Q16570
Rat DARC DARC 689105  
DARC 13349 Q9QUI6
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Top DARC Proteins at antibodies-online.com

Showing 8 out of 9 products:

Catalog No. Origin Source Conjugate Images Quantity Delivery Price Details
Insect Cells Mouse rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.25 mg 50 to 55 Days
$5,262.31
Details
Insect Cells Human rho-1D4 tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 0.5 mg 50 to 55 Days
$7,493.38
Details
Escherichia coli (E. coli) Mouse His tag,GST tag 100 μg 15 to 18 Days
$720.00
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg 11 Days
$888.80
Details
Wheat germ Human GST tag 10 μg 11 to 12 Days
$340.00
Details
Escherichia coli (E. coli) Human His tag   50 μg 13 to 16 Days
$410.00
Details
Wheat germ Human Un-conjugated   2 μg 11 to 12 Days
$491.43
Details
Escherichia coli (E. coli) Human Un-conjugated   100 μg 11 to 18 Days
$668.03
Details

DARC Proteins by Origin and Source

Origin Expressed in Conjugate
Human , , ,
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Mouse (Murine) ,
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More Proteins for Duffy Blood Group, Chemokine Receptor (DARC) Interaction Partners

Human Duffy Blood Group, Chemokine Receptor (DARC) interaction partners

  1. Presence of high level of DARC expression with high level of heterozygosity (FyA/FyB genotype) might have a role to play in the increased susceptibility to P. vivax malaria.

  2. High-throughput Kell, Kidd, and Duffy matrix-assisted laser desorption/ionization, time-of-flight mass spectrometry-based blood group genotyping of 4000 donors shows close to full concordance with serotyping and detects new alleles.

  3. The mean number of rosettes formed by erythrocytes surrounding transfected mammalian COS-7 cells which expressed Plasmodium knowlesi Duffy binding protein differ between erythrocytes' Duffy antigen phenotypes. Plasmodium knowlesi Duffy binding protein displays higher binding to Fy(a+/b+) erythrocytes than to Fy(a+/b-) erythrocytes.

  4. The atypical chemokine receptor 1 polymorphism (rs12075) does not affect susceptibility to hepatitis C virus.

  5. The risk of Plasmodium vivax malaria associated with genetic variation of DARC in Thai patients is reported.

  6. Our findings in mice suggest that DARC alters the severity and resolution of AHR. These findings are complimented by our human analyses in which select DARC SNPs are associated with worse asthma control and symptoms.

  7. DARC expression in cancer cells inhibits pancreatic ductal adenocarcinoma progression by suppressing STAT3 activation through the inhibition of CXCR2 signaling

  8. This study reports 1-3 occurrences of P. vivax infection in each of 25 Duffy-negative children at six time points over two rainy seasons and the beginning of the third season.

  9. Data suggest that Type II congenital smell loss patients who exhibit both type I hyposmia and hypogeusia are genetically distinct from all other patients with Type II congenital smell loss. This distinction is based on decreased Fy(b) expression which correlated with abnormalities in two sensory modalities (hyposmia type I and hypogeusia).

  10. The data suggest that selective exposure of the Duffy binding protein (DBP) binding site within DARC is key to the preferential binding of DBP to immature reticulocytes, which is the potential mechanism underlying the preferential infection of a reticulocyte subset by P vivax.

  11. ACKR1 regulates neutrophil counts in blood. Lack of ACKR1 on nucleated erythroid cells together with its expression in endothelial cells causes neutropenia.

  12. population genetic analysis of DARC shows its association with malaria resistance

  13. Molecular identification of rare FY*Null and FY*X alleles in Caucasian thalassemic family from Sardinia.

  14. We showed that DARC expression is down-regulated in CRC and associated with clinical pathological features and MVD of CRC. DARC might be involved in tumorigenesis, progression, angiogenesis, and metastasis of CRC.

  15. DARC is required for Staphylococcus aureus-mediated lysis of human erythrocytes, and DARC overexpression is sufficient to render cells susceptible to toxin-mediated lysis.

  16. the odds for neutropenia in the ACKR1-null (FY-) individuals were 46-fold higher than for FY+ individuals (Crude odds ratio = 46, 95% confidence interval = 8.03-263, P < 0.001)

  17. study demonstrates the association of SNP rs12075 from DARC gene with the levels of serum IL8

  18. DARC levels are elevated in human keloid fibroblasts and might inhibit the secretion of CCL2.

  19. Through molecular genotyping we also identified polymorphisms in RhCE, Kell, Duffy, Colton, Lutheran and Scianna loci in donors and patients.

  20. The majority of our population is heterozygous for Duffy antigens a and b.

Mouse (Murine) Duffy Blood Group, Chemokine Receptor (DARC) interaction partners

  1. Chemokines CXCL1 and CXCL2 and the Atypical Receptor ACKR1 are involved in neutrophil emigration.

  2. DARC regulates metabolic function and adipose tissue inflammation.

  3. Our findings in mice suggest that DARC alters the severity and resolution of AHR. These findings are complimented by our human analyses in which select DARC SNPs are associated with worse asthma control and symptoms.

  4. DARC was exquisitely restricted to post-capillary and small collecting venules and completely absent from arteries, arterioles, capillaries, veins, and most lymphatics in every tissue analyzed. Intravital microscopy showed that adhesive leukocyte-endothelial interactions were restricted to DARC(+) venules. DARC was detectable over the entire circumference of V-ECs, but was more concentrated at cell-cell junctions.

  5. DARC regulates recruitment of osteoclast precursors at the inflammation site

  6. Nucleated erythroid cells had high expression of ACKR1, which facilitated their direct contact with hematopoietic stem cells. The absence of erythroid ACKR1 altered mouse hematopoiesis including stem and progenitor cells, which ultimately gave rise to phenotypically distinct neutrophils that readily left the circulation, causing neutropenia.

  7. The DARC/CD234 is expressed on macrophages and stabilizes CD82 on long-term repopulating hematopoietic stem cells, promoting their quiescence.

  8. Ackr1 deficiency appears to be protective in the ApoE knockout model of atherogenesis, but it is associated with only modest changes in cytokine and chemokine expression as well as T-cell subset frequency and inflammatory macrophage content.

  9. the results suggest that normal motor function and behavior may partly depend on negative regulation of Purkinje cell activity by Ackr1.

  10. Darc plays a role in modulating the regulation of inflammatory response to bone injury and that lack of Darc expression promotes cartilage formation in fracture calluses but does not affect bony union or fracture healing at 21 days post-fracture.

  11. The data showed a role for erythrocyte DARC as a chemokine reservoir and that endothelial DARC contributes to the pathogenesis of experimental autoimmune encephalomyelitis by shuttling chemokines across the blood-brain barrier.

  12. DARC is crucial for chemokine-mediated leukocyte recruitment in vivo.

  13. Plasmodium yoelii uses the murine Duffy antigen receptor for chemokines as a receptor for normocyte invasion and an alternative receptor for reticulocyte invasion.

  14. Vascular endothelial cells may induce Duffy protein to regulate leukocytes and/or chemokine trafficking

  15. role of the Duffy antigen and glycophorin A as receptors for rodent malaria parasite invasion of erythrocytes

  16. we have defined the binding domain on the mDuffy protein for Plasmodium yoelii binding to erythrocytes

  17. DARC functions to clear angiogenic CXC chemokines from the prostate tumor microcirculation

  18. Darc regulates bone mineral density (BMD)negatively by increasing osteoclast formation. Darc is proposed as a candidate gene for chromosome 1 BMD QTL2.

  19. Results indicate that endothelial cell overexpression of mDARC increased leukocyte trafficking to the tumor, reduced the growth of blood vessels into the tumor, and reduced the growth rate of melanoma.

  20. Loss of red cell chemokine scavenging promotes transfusion-related lung inflammation

Cow (Bovine) Duffy Blood Group, Chemokine Receptor (DARC) interaction partners

  1. the 5' flanking region of the DARC gene was isolated and characterized

DARC Protein Profile

Protein Summary

The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene.

Gene names and symbols associated with DARC

  • Duffy blood group, chemokine receptor (DARC)
  • atypical chemokine receptor 1 (Duffy blood group) (ACKR1)
  • atypical chemokine receptor 1 (Ackr1)
  • atypical chemokine receptor 1 (Duffy blood group) (Ackr1)
  • AA162249 protein
  • Ackr1 protein
  • CCBP1 protein
  • CD234 protein
  • DARC protein
  • Dfy protein
  • ESTM35 protein
  • FY protein
  • GPD protein
  • GpFy protein
  • WBCQ1 protein

Protein level used designations for DARC

Duffy blood group, chemokine receptor , duffy antigen/chemokine receptor , Duffy antigen/chemokine receptor , Duffy blood group antigen , Fy glycoprotein , atypical chemokine receptor 1 , glycoprotein D , plasmodium vivax receptor , Duffy antigen receptor for chemokines , blood group antigen , duffy antigen/receptor for chemokine glycoprotein

GENE ID SPECIES
396618 Sus scrofa
478969 Canis lupus familiaris
100398804 Callithrix jacchus
100458473 Pongo abelii
100500770 Papio anubis
2532 Homo sapiens
689105 Rattus norvegicus
13349 Mus musculus
528076 Bos taurus
745985 Pan troglodytes
719284 Macaca mulatta
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