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The protein encoded by EPDR1 is a type II transmembrane protein that is similar to two families of cell adhesion molecules, the protocadherins and ependymins.
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Study results suggest functional involvement of EPDR1 in the etiology of Dupuytren's Disease.
EPDR1 exhibits a pattern of isoform abundance dependent on KRAS G13D and G12D mutations.
Results of this study suggest that EPDR1 gene can be added to a growing list of genes associated with Dupuytren's disease development.
Shows that the mouse ortholog is a lysosomal protein.
A novel density shift method was used to demonstrate that EPDR resides in the lysosome.
The protein encoded by this gene is a type II transmembrane protein that is similar to two families of cell adhesion molecules, the protocadherins and ependymins. This protein may play a role in calcium-dependent cell adhesion. This protein is glycosylated, and the orthologous mouse protein is localized to the lysosome. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 8.
ependymin related protein 1 (zebrafish)
, ependymin related protein 1
, mammalian ependymin related protein 1
, mammalian ependymin-related protein 1
, upregulated in colorectal cancer gene 1 protein
, ependymin 2
, ependymin related protein 2
, upregulated in colorectal cancer gene 1