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FBXO32 encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Additionally we are shipping FBXO32 Kits (30) and FBXO32 Proteins (9) and many more products for this protein.
Showing 10 out of 78 products:
Human Polyclonal FBXO32 Primary Antibody for ELISA, WB - ABIN451805
Hanai, Cao, Tanksale, Imamura, Koshimizu, Zhao, Kishi, Yamashita, Phillips, Sukhatme, Lecker: The muscle-specific ubiquitin ligase atrogin-1/MAFbx mediates statin-induced muscle toxicity. in The Journal of clinical investigation 2007
Human Polyclonal FBXO32 Primary Antibody for IF (p), IHC (p) - ABIN747698
Lin, Hanson, Betik, Brennan-Speranza, Hayes, Levinger: Hindlimb Immobilization, But Not Castration, Induces Reduction of Undercarboxylated Osteocalcin Associated With Muscle Atrophy in Rats. in Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2016
Atrogin-1 inactivation leads to progressive impairment of heart and skeletal muscle function and structure. Autophagy is severely impaired in Atrogin-1-deficient zebrafish embryos.
Results suggest that the up-regulation of FBXO32 is associated with skeletal and smooth muscle atrophy that occurs during fasting.
Transcriptional analysis of endophilin-A mutant mice, complemented by proteomics, highlighted ataxia- and protein-homeostasis-related genes and revealed upregulation of the E3-ubiquitin ligase (show MUL1 Antibodies) FBXO32/atrogin-1 and its transcription factor FOXO3A (show FOXO3 Antibodies).
Low FBXO32 expression is associated with breast cancer tumorigenesis.
the involvement of oxidative stress in the atrophy of COPD peripheral muscle cells in vitro, via the FoxO1/MuRF1/atrogin-1 signaling pathway of the ubiquitin/proteasome system
These results have revealed the roles for atrogin-1 in the regulation of smooth muscle contractility through enhancement of myocardin (show MYOCD Antibodies) ubiquitylation/degradation and its transcriptional activity.
Our results indicate that abnormal SCF (show KITLG Antibodies) activity with subsequent impairment of the autophagic flux due to a novel FBXO32 mutation is implicated in the pathogenesis of Dilated cardiomyopathy .
Our data suggest that FBXO32 is a candidate gene for recessive familial dilated cardiomyopathy. Acting as a cardiac ubiquitin ligase, mutated FBXO32 could perturb the degradation of target proteins in the ubiquitin proteasome system.
Vitamin D3 might have an inhibitory effect on the expression of MAFbx and MuRF1 (show TRIM63 Antibodies) in skeletal muscle.
Atrogin-1 expression tended to be increased in the skeletal muscle of patients with malignant disease even before c (show TNF Antibodies)ancer related cachexia weight loss.
Expression of USP19 (show USP19 Antibodies) correlates with that of MuRF1 (show TRIM63 Antibodies) and MAFbx/atrogin-1 in skeletal muscles
FBXO32 targets Lys (show LYZ Antibodies)-326 of c-Myc (show MYC Antibodies) to form polyubiquitin (show UBB Antibodies) chains, resulting in inhibition of cell proliferation.
this study shows that aspartate suppresses lipopolysaccharide-induced MAFbx expression in skeletal muscle via activation of Akt (show AKT1 Antibodies) signaling, and inhibition of AMPKa and FOXO1 (show FOXO1 Antibodies) signaling
Porcine congenital splayleg (PCS) is a condition characterized by extensive fibre atrophy and raised fibre density. The combined differential expression of MAFbx and P311 (show C5orf13 Antibodies) is of potential in the diagnosis of subclinical PCS.
A study on the variability of bovine FBXO32 gene that is predictive of genetic potential for body length phenotype.
Valproic acid attenuated muscle wasting and myotube atrophy and reduced C/EBPbeta (show CEBPB Antibodies) binding to atrogin1 promoter locus in the myotubes.
educed PABPN1 (show PABPN1 Antibodies) levels caused a consistent decline in distal PAS (show PASK Antibodies) utilization in the 3'-UTR (show UTS2R Antibodies) of a subset of OPMD-dysregulated genes. This alternative PAS (show PASK Antibodies) utilization led to up-regulation of Atrogin-1, a key muscle atrophy regulator, but down regulation of proteasomal genes. Additionally reduced PABPN1 (show PABPN1 Antibodies) levels caused a reduction in proteasomal activity, and transition in MyHC (show MYH13 Antibodies) isotope expression pattern in myofibers.
Iron-induced skeletal muscle atrophy is suggested to involve the E3 ubiquitin ligase (show MUL1 Antibodies) mediated by the reduction of Akt (show AKT1 Antibodies)-FOXO3a (show FOXO3 Antibodies) signaling by oxidative stress.
MAFbx mRNA expression was decreased in old mice relative to adult mice, whereas MuRF1 (show TRIM63 Antibodies) mRNA expression was less affected by ageing
Suggest role for atrogin-1 up-regulation in simvastatin-induced heart mitochondria dysfunction.
Atrogin1 was upregulated in cancer cachexia mice. Atrogin1 knockdown protected skeletal muscle cells from TNF-alpha (show TNF Antibodies) induced atrophy.
MAFbx not only regulates protein degradation, but also reduces protein synthesis, exerting a dual role in regulating cardiac mass and preventing from cardiac hypertrophy.
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class and contains an F-box domain. This protein is highly expressed during muscle atrophy, whereas mice deficient in this gene were found to be resistant to atrophy. This protein is thus a potential drug target for the treatment of muscle atrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.
F-box only protein 32
, F-box protein 32
, F-box only protein 32-like
, atrogin 1
, muscle atrophy F-box protein
, atrophy gene 1