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Stimulates the proliferation of early hematopoietic cells by activating FLT3. Additionally we are shipping FMS-Like tyrosine Kinase 3 Ligand Antibodies (7) and FMS-Like tyrosine Kinase 3 Ligand Proteins (6) and many more products for this protein.
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Flt3L could enhance the efficacy of immune checkpoint blockades in glioblastoma via expanding CD103+ dendritic cells and downstream antitumor immune response.
Intratumoral administration of the STING agonist cyclic di-GMP (show NT5C2 ELISA Kits) (CDG) or Flt3 Ligand (Flt3L (show FLT3LG ELISA Kits)) augmented the therapeutic effect of systemic triple checkpoint modulation and promoted the cure of 75% of mice with bilateral TRAMP (show DPT ELISA Kits)-C2; however, when all agents were administered locally, only CDG mobilized abscopal immunity
both Flt3 ligand (FL (show FLT3LG ELISA Kits)) and IL-7 (show IL7 ELISA Kits) regulate B-cell commitment in a permissive manner: FL by inducing proliferation of Ly6D (show LY6D ELISA Kits)(+)CD135 (show FLT3 ELISA Kits)(+)CD127 (show IL7R ELISA Kits)(+)CD19 (show CD19 ELISA Kits)(-) progenitors and IL-7 (show IL7 ELISA Kits) by providing survival signals to these progenitors
Data show that FLT3 ligand (FLT3L (show FLT3LG ELISA Kits)) enhances thymopoiesis through increased survival and export of hematopoietic stem cell (Lin([minus])Sca1 (show ATXN1 ELISA Kits)(+)c-Kit(+) [LSK (show LCK ELISA Kits)] cells via CXCR4 (show CXCR4 ELISA Kits) receptor regulation.
these results demonstrate that the lack of Flt3L (show FLT3LG ELISA Kits) mRNA expression in hematopoietic stem cells is yet another marker which further defines the status of long-term repopulating -hematopoietic stem cells
this study shows that ionizing radiation induces a decrease of CD8 (show CD8A ELISA Kits)+ dendritic cells and Th1 (show HAND1 ELISA Kits)/Th2 shift, which was reversed by Flt3 ligand (show FLT3LG ELISA Kits) treatment, suggesting a novel mechanism for radiation-induced immunosuppression
may be mediated by Flt3L (show FLT3LG ELISA Kits)- and MMP-9 (show MMP9 ELISA Kits)-dependent mobilization of dendritic cells
Bone marrow-derived CD117+ hematopoietic progenitor cells differentiate into thymic dendritic cells in the fetal thymus organ culture system in the presence of Flt3L (show FLT3LG ELISA Kits).
Flt3L (show FLT3LG ELISA Kits) significantly contributes to innate lymphoid cells and Peyer's patches development by targeting lymphoid progenitor cells during fetal and adult life.
unlike G-CSF (show CSF3 ELISA Kits), Flt3 (show FLT3 ELISA Kits)-L had an indirect effect on EI macrophages, as it was not detected at the surface of EI macrophages or erythroid progenitors.
Stimulates the proliferation of early hematopoietic cells by activating FLT3. Synergizes well with a number of other colony stimulating factors and interleukins.
, fms-related tyrosine kinase 3 ligand
, fms-like tyrosine kinase 3 ligand