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The protein encoded by FOXN1 is part of the forkhead family or 'winged-helix' transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging.
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Human Polyclonal FOXN1 Primary Antibody for IF (p), IHC (p) - ABIN1387592
Volpi, Yamazaki, Brauer, van Rooijen, Hayashida, Slavotinek, Sun Kuehn, Di Rocco, Rivolta, Bortolomai, Du, Felgentreff, Ott de Bruin, Hayashida, Freedman, Marcovecchio, Capuder, Rath, Luche, Hagedorn et al.: EXTL3
mutations cause skeletal dysplasia, immune deficiency, and developmental delay. ... in The Journal of experimental medicine 2017
Human Polyclonal FOXN1 Primary Antibody for IHC (p), IHC - ABIN250004
Schlake, Schorpp, Maul-Pavicic, Malashenko, Boehm: Forkhead/winged-helix transcription factor Whn regulates hair keratin gene expression: molecular analysis of the nude skin phenotype. in Developmental dynamics : an official publication of the American Association of Anatomists 2000
the foxn1-mcm2 (show MCM2 Antibodies) axis plays a central role in the genetic regulatory network controlling thymus development in zebrafish
zebrafish orthologue (whnb) of the mouse nude gene is expressed in the epithelial compartment of the embryonic thymic rudiment
an evolutionarily conserved role of BMP signaling in the maintenance of Foxn1 expression.
FOXN1 founder Italian mutation identified in an indian newborn with severe combined immunodeficiency (show PRKDC Antibodies).
Whole-exome sequencing in a South American coh (show RARB Antibodies)ort links ALDH1A3, FOXN1 and RARB/retinoic acid regulation pathways to autism s (show ALDH1A3 Antibodies)pectrum disorders.
Identification of a unique mutation in FOXN1 that led to severe combined immunodeficiency (show PRKDC Antibodies) in a female infant is reported.
These results show that miR (show MLXIP Antibodies)-18b and miR (show MLXIP Antibodies)-518b are upstream controllers of FOXN1-directed epithelial lineage development.
The retinoid-related orphan receptor (show NR1D2 Antibodies) RORalpha promotes keratinocyte differentiation via FOXN1.
This is the first description of leucoderma occurring in a patient with Foxn1 deficiency, as well as the first report of this pigment abnormality following thymus transplantation.
results show that FOXN1 is crucial for in utero T cell development, but not for B and NK cell differentiation
role of FOXN1 in immunological disorders characterized by abnormal T-cell development or abnormal T-cell regulatory homeostasis [Review]
study uncovered a positive regulatory loop between FGFR3 (show FGFR3 Antibodies) and FOXN1 that underlies a benign versus malignant skin tumor phenotype
Mutation of the FOXN1 gene is associated with congenital severe combined immunodeficiency (show PRKDC Antibodies) associated with alopecia
data identify the transcription factor Foxn1 (show FOXN2 Antibodies) as a potential key epidermal regulator modifying both epidermal and dermal healing processes after cutaneous wounding
MicroRNA-205 maintains T cell development following stress by regulating Foxn1 (show FOXN2 Antibodies) and its two regulated targets, stem cell factor (show KITLG Antibodies) and ccl25 (show CCL25 Antibodies), following stress.
this study identified Bmp4 (show BMP4 Antibodies) as a significant factor for improved maintenance of Foxn1 (show FOXN2 Antibodies) expression, promotion of thymic epithelial progenitor populations self-renewal and immature epithelial cell differentiation and survival
results show that Foxn1 (show FOXN2 Antibodies), and alleles under its control, are expressed in the pre-meiotic male germline, revealing a new tool for germline targeting of genes, and raising important concerns for gender selection when using Foxn1 (show FOXN2 Antibodies) regulatory elements.
this study shows that critical events in thymic lympho-stromal cross-talk and T cell selection are regulated by Foxn1 (show FOXN2 Antibodies)
sphingolipids and fatty acids associated with a decrease in glycerolipids suggest that the lipidome in mice skin is regulated by the Foxn1 (show FOXN2 Antibodies) gene
Foxn1 (show FOXN2 Antibodies) transcription factor regulates wound healing of skin through promoting epithelial-mesenchymal transition.
early differentiation and maturation of cortical and medullary thymic epithelial cells coincides with precise sub-lineage-specific regulation of Foxn1 (show FOXN2 Antibodies) expression levels.
Chromatin immunoprecipitation assay using RarB (show RARB Antibodies) as the immunoprecipitation target suggests retinoic acid regulation of Aldh1a3 (show ALDH1A3 Antibodies) and Foxn1 (show FOXN2 Antibodies) in mice.
The maturation and distribution of thymic epithelial cells in the Foxn1 (show FOXN2 Antibodies)(-/-) thymic rudiment and the thymopoiesis of this newly developed rudiment, were examined.
The protein encoded by this gene is part of the forkhead family or 'winged-helix' transcription factors that are important in developmental processes, immune system regulation, metabolism, cancer and aging. This gene family has over 100 members, subdivided into classes (A-Q) based on phylogeny. The encoded protein is proposed to regulate development of the thymus and differentiation of keratinocytes. Mutations in this gene cause severe primary T-cell immunodeficiency and congenital alopecia. In mouse mutations of this gene underlie the phenotype of the nude mouse, which has been widely used as a model system in oncology, immunology, dermatology, and transplantation studies. In humans mutations in this gene have been correlated with T-cell immunodeficiency, the skin disorder congenital alopecia, and nail dystrophy. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
forkhead box protein N1
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, forkhead box N protein
, forkhead box protein N1-like
, transcription factor Forkhead box protein N1
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, HNF-3/forkhead homolog 11
, hepatocyte nuclear factor 3 forkhead homolog 11