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GCET2 encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. Additionally we are shipping Germinal Center Expressed Transcript 2 Proteins (7) and Germinal Center Expressed Transcript 2 Kits (3) and many more products for this protein.
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Assays identified a non-consensus binding site for Sp factors near sites of transcriptional initiation. The site binds Spl and Sp3 in nuclear extracts.
Diagnostic Utility of the Germinal Center-associated Markers GCET1 (show SERPINA9 Antibodies), HGAL, and LMO2 (show LMO2 Antibodies) in Hematolymphoid Neoplasms.
These findings further elucidate the growing and complex role of HGAL in B-cell biology and suggest that membrane-bound and cytoplasmic HGAL protein differently regulates distinct biological processes.
HGAL and LMO2 (show LMO2 Antibodies) may be useful adjuncts in the identification of follicular lymphoma of the nongastric gastrointestinal tract.
the germinal centre protein human germinal centre-associated lymphoma regulates B-cell receptor signalling in B-lymphocytes which, without appropriate control, may lead to B (show TDO2 Antibodies)-cell lymphoproliferation (show FAS Antibodies).
HGAL/GCET2 protein expression may function as a marker for germinal center B-cell type diffuse large B-cell lymphoma.
Immunostaining for HGAL was more frequently positive than that for BCL6 (show BCL6 Antibodies) and CD10 (show MME Antibodies) in follicular lymphomas
Data suggest that both HGAL and LMO2 (show LMO2 Antibodies) are directly regulated by the transcription repressor PRDM1 (show PRDM1 Antibodies)--overexpression of PRDM1 (show PRDM1 Antibodies) down-regulates HGAL and LMO2 (show LMO2 Antibodies); PRDM1 (show PRDM1 Antibodies) directly binds to promoters of both HGAL and LMO2 (show LMO2 Antibodies) and represses genetic transcription.
show that HGAL increases the binding of myosin to F-actin and inhibits the ability of myosin to translocate actin by reducing the maximal velocity of myosin head/actin movement
HGAL is sensitive and specific marker for detecting follicular lymphoma in nodal and extranodal sites
molecular mechanism underlying the inhibitory effects of germinal center-specific HGAL protein on the motility of GC-derived lymphoma cells
This gene encodes a protein which may function in signal transduction pathways and whose expression is elevated in germinal cell lymphomas. It contains a putative PDZ-interacting domain, an immunoreceptor tyrosine-based activation motif (ITAM), and two putative SH2 binding sites. In B cells, its expression is specifically induced by interleukin-4. Alternative splicing results in multiple transcript variants encoding different isoforms.
germinal center B-cell-expressed transcript 2 protein
, germinal center expressed transcript 2
, germinal center-associated signaling and motility protein
, germinal center-associated lymphoma protein
, human germinal center-associated lymphoma