anti-Gremlin 2, DAN Family BMP Antagonist (GREM2) Antibodies

GREM2 encodes a member of the BMP (bone morphogenic protein) antagonist family. Additionally we are shipping and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
GREM2 23893 O88273
GREM2 64388 Q9H772
GREM2    
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Top anti-Gremlin 2, DAN Family BMP Antagonist Antibodies at antibodies-online.com

Showing 5 out of 5 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, IHC (p), WB Western Blot: PRDC/GREM2 Antibody  diluted at 1:500. Western Blot: PRDC/GREM2 Antibody  diluted at 1:500. 0.1 mL Log in to see 7 to 9 Days
$444.19
Details
Human Rabbit Un-conjugated WB Western Blot: PRDC/GREM2 Antibody [NBP1-57598] - 721_B cell lysate, concentration 0.2-1 ug/ml. 100 μL Log in to see 8 to 11 Days
$485.88
Details
Human Rabbit Un-conjugated WB Western Blot: PRDC/GREM2 Antibody [NBP2-41923] - Analysis using recombinant human Gremlin -2. Lane 1: 5 ng Lane 2: 10 ng Lane 3: 50 ng Lane 4: 100 ng 100 μg Log in to see 8 to 11 Days
$485.88
Details
Human Rabbit Alexa Fluor 488 IHC, IHC (p), WB   0.1 mL Log in to see 10 to 13 Days
$556.31
Details
Human Rabbit DyLight 594 IHC, IHC (p), WB   0.1 mL Log in to see 10 to 13 Days
$556.31
Details

GREM2 Antibodies by Reactivity, Application, Clonality and Conjugate

Attributes Applications Host Clonality Conjugate
Mouse (Murine)


Human


,
Rat (Rattus)


More Antibodies against Gremlin 2, DAN Family BMP Antagonist Interaction Partners

Mouse (Murine) Gremlin 2, DAN Family BMP Antagonist (GREM2) interaction partners

  1. Grem2 knockdown inhibited cardiomyocyte differentiation, and this effect was similar to that of Notch1 (show NOTCH1 Antibodies) pathway inhibition in vitro. Grem2 enhances the protective effect of cardiac progenitor cells on heart function in a mouse model of myocardial infarction.

  2. Grem2 provides a molecular barrier that controls the extent of inflammatory cell infiltration by suppressing BMP2 (show BMP2 Antibodies) after myocardial infarction.

  3. Grem2 expression is regulated during development and embryonic stem cell differentiation.

  4. PRDC binds heparin with high affinity and that heparin binding to PRDC interferes with BMP antagonism.

  5. We show that Tbx2 directly represses Grem1 in distal regions of the posterior limb mesenchyme allowing Bone morphogenetic protein (Bmp) signaling to abrogate Fgf4/9/17 expression in the overlying epithelium.

  6. Through a combination of biophysical and biochemical studies, the authors determined that PRDC forms biologically active dimers that potently inhibit BMP ligands.

  7. The differential regulation of Gremlin2 gene expressions by BMP2 (show BMP2 Antibodies) may explain the critical function of these genes during osteoblast differentiation.

  8. ovarian PRDC expressed in granulosa cells could be involved in follicular development by antagonizing the actions of theca cell-derived Bone morphogenetic proteins

  9. We propose that PRDC might serve as a mediator to antagonize BMP-4 (show BMP4 Antibodies) signaling by Wnt (show WNT2 Antibodies).

  10. PRDC expression in osteoblasts suppresses differentiation and that reduction of PRDC expression promotes osteogenesis in vitro. PRDC is accordingly identified as a potential novel therapeutic target for the regulation of bone formation.

Human Gremlin 2, DAN Family BMP Antagonist (GREM2) interaction partners

  1. Data show that the GREMLIN 2 (GREM2) expression during Induced Pluripotent Stem Cell (hiPS) cell cardiac differentiation follows the expression pattern of cardiac-specific genes.

  2. The structure of Grem2-GDF5 (show GDF5 Antibodies) complex has revealed a number of key findings for DAN-family mediated BMP2 (show BMP2 Antibodies) inhibition.

  3. This study showed that si-Grem2 increased the BMP-2 (show BMP2 Antibodies)-induced osteogenic differentiation of hBMSCs via the BMP-2 (show BMP2 Antibodies)/Smad (show SMAD1 Antibodies)/Runx2 (show RUNX2 Antibodies) pathway.

  4. The present study shows that the Grem2 heparin/HS and BMP2 (show BMP2 Antibodies)-binding epitopes are unique and independent, where the Grem2-BMP2 (show BMP2 Antibodies) complex exhibits a significant increase in binding affinity toward heparin moieties that appear to be partially independent of the Grem2 heparin/HS-binding epitope.

  5. Gremlin 2 inhibits adipocyte differentiation through activation of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) signaling

  6. GREM2 variants have been identified in atrial fibrillation cohort studies, demonstrating abnormalities in cardiac excitation - supra ventricular tachycardia and atrial fibrillation.

  7. The minor allele of rs4454537 is significantly associated with low bone density at the total hip of southern Chinese people. Our study further suggests GREM2 as a novel susceptibility gene for osteoporosis.

  8. Through regulation of bone morphogenetic protein signaling, GREM2 is required for cardiac laterality and atrial differentiation during embryonic development.

  9. and that a genetic variant in the FMN2 (show FMN2 Antibodies)/GREM2 locus influences GREM2 expression in osteoblasts and thereby trabecular number and thickness as well as fracture risk.

Gremlin 2, DAN Family BMP Antagonist (GREM2) Antigen Profile

Protein Summary

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation.

Gene names and symbols associated with GREM2

  • gremlin 2, DAN family BMP antagonist (Grem2) antibody
  • gremlin 2, DAN family BMP antagonist (GREM2) antibody
  • CKTSF1B2 antibody
  • DAND3 antibody
  • Gremlin2 antibody
  • PRDC antibody

Protein level used designations for GREM2

Gremlin1 , cysteine knot superfamily 1, BMP antagonist 2 , gremlin-2 , protein related to DAN and cerberus , DAN domain family member 3 , gremlin 2, cysteine knot superfamily, homolog

GENE ID SPECIES
23893 Mus musculus
64388 Homo sapiens
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