anti-HESX Homeobox 1 (HESX1) Antibodies

HESX1 encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Additionally we are shipping HESX Homeobox 1 Proteins (14) and HESX Homeobox 1 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
HESX1 15209 Q61658
HESX1 498575  
HESX1 8820 Q9UBX0
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Top anti-HESX Homeobox 1 Antibodies at antibodies-online.com

Showing 10 out of 33 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Human Rabbit Un-conjugated IHC, IHC (p) Immunocytochemistry/Immunofluorescence: HESX1 Antibody [NBP1-89090] - Staining of human cell line U-251 MG shows positivity in nucleus but not nucleoli. Immunohistochemistry-Paraffin: HESX1 Antibody [NBP1-89090] - Staining of human kidney shows distinct nuclear positivity in tubular and glomerular cells. 0.1 mL Log in to see 10 to 13 Days
$494.38
Details
Human Mouse Un-conjugated WB Western Blot analysis of HESX1 expression in transfected 293T cell line by HESX1 MaxPab polyclonal antibody.Lane 1: HESX1 transfected lysate(20.35 KDa).Lane 2: Non-transfected lysate. 50 μL Log in to see 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated ELISA, WB Detection limit for recombinant GST tagged HESX1 is approximately 1ng/ml as a capture antibody. Western Blot detection against Immunogen (37.84 KDa) . 100 μg Log in to see 11 to 12 Days
$440.00
Details
Human Mouse Un-conjugated ELISA, WB   100 μg Log in to see 11 to 14 Days
$837.83
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 11 to 13 Days
$335.04
Details
Human Rabbit Un-conjugated ELISA, WB   100 μL Log in to see 11 to 13 Days
$335.04
Details
Human Rabbit Alexa Fluor 350 IF (p)   100 μL Log in to see 14 to 21 Days
$416.90
Details
Human Rabbit Cy5 IF (p)   100 μL Log in to see 14 to 21 Days
$416.90
Details
Human Rabbit Cy5.5 IF (p)   100 μL Log in to see 14 to 21 Days
$416.90
Details
Human Rabbit Alexa Fluor 647 IF (p)   100 μL Log in to see 14 to 21 Days
$416.90
Details

More Antibodies against HESX Homeobox 1 Interaction Partners

Mouse (Murine) HESX Homeobox 1 (HESX1) interaction partners

  1. Hesx1 plays a significant role in sustaining pluripotency in embryonic stem cells.Hesx1 transcriptionally suppresses differentiation-related genes.

  2. Wnt inhibition during the first day has larger impact on the activation of Hesx1 and Six3, suggesting that in embryos Wnt inhibition caused by Dkk1 contributes greatly in the establishment of the anterior forebrain precursor.

  3. Variability in Hes1 expression therefore helps to explain why STAT3 responsiveness varies between individual ES cells, and this in turn helps to explain why pluripotent cells commit to differentiate asynchronously..

  4. Transcriptional profiling of anterior forebrain precursors from mouse embryos expressing eGFP from the Hesx1 locus provides molecular evidence supporting a novel function of Hesx1 in mediating repression of Wnt/beta-catenin target activation.

  5. Studies suggest that TLE1 and TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1.

  6. Data suggest that formation of a heterodimer between HESX1 and PROP1 allows HESX1 to become active, and that PROP1 then replaces HESX1 to advance to the middle stage of pituitary development.

  7. A novel inducible element, activated by contact with Rathke's pouch, is present in the regulatory region of the Hesx1 homeobox gene.

  8. the domains of Hes-1 needed to block adipogenesis coincide with those necessary for transcriptional repression.

  9. Conserved regulatory elements establish the dynamic expression of Rpx in early development.

  10. The absence of Hesx1 leads to a posterior transformation of the anterior forebrain (AFB) during mouse development.

  11. establish a link between HESX1 and DNMT1 and suggest a novel mechanism for the repressing properties of HESX1

  12. Haploinsufficiency of both Six3 and Hesx1 leads to severe pituitary dysmorphogenesis during development, which results in hypopituitarism with dramatic postnatal growth retardation.

  13. Hesx1(I26T/I26T) embryos show pituitary defects comparable with Hesx1(-/-) mouse mutants, with frequent occurrence of ocular abnormalities, although the telencephalon develops normally

Human HESX Homeobox 1 (HESX1) interaction partners

  1. Study did not identify HESX1 and LHX3 mutations by Sanger in brazilian patients with combined pituitary hormone deficiency

  2. HESX1 mutations cause variable clinical features in congenital hypopituitarism patients, which suggests an influence of modifier genes or environmental factors on the phenotype

  3. A novel heterozygous mutation in the HESX1 gene and a novel homozygous mutation in the PROP1 gene were detected in 2 pedigrees with combined pituitary hormone deficiency

  4. investigated the specific mutations in PROP1, POU1F1, LHX3, and HESX1 genes in patients with combined pituitary hormone deficiency (CPHD) in Turkey

  5. Data indicate that HESX1, LHX4 and SOX3 polymorphisms may be associated with pituitary stalk interruption syndrome (PSIS).

  6. expand the phenotypic spectrum of HESX1 mutations in Kallman syndrome.

  7. Data show no mutations in HESX1, PROP1, and POU1F1 genes, seven different mutations in CTNNB1 in 8/16 patients, and hyperexpression of miR-150.

  8. A c.357+3G>A mutation prevents the generation of one of the alternative isoforms normally produced by the wild-type allele, predicting a truncated HESX1 protein.

  9. A novel HESX1 causative mutation was found in a consanguineous family, and two LHX4 mutations were present in familial Pituitary stalk interruption syndrome.

  10. Mutations in the PROP1 and HESX1 genes were not identified in these patients with sporadic growth hormone defiency, combined pituitary hormone deficiency and septo-optic dysplasia.

  11. A large cohort of patients with schizencephaly, some with features of septo-optic dysplasia, were sequenced for mutations in LHX2, HESX1 and SOX2.

  12. Studies suggest that TLE1 and TLE3 might also play roles independent of HESX1 by interacting with other transcription factors like PROP1.

  13. HESX1 mutations in septo-optic dysplasia will lead to a detailed understanding of its function in the development of the forebrain and pituitary--review

  14. Sporadic heterozygous frameshift mutation of HESX1 causing pituitary and optic nerve hypoplasia and combined pituitary hormone deficiency in a Japanese patient. The insertion of a heterozygous mutation (306/307ins AG) in the exon 2 of the HESX1.

  15. novel HESX1 mutation in genomic nucleotide position 1684 (g.1684delG), which results in a mutant protein with increased DNA binding causing repression of PROP1 gene activity

  16. "HESX1, a paired-like homeotic gene, has recently been reported to be defective in two siblings with septo-optic dysplasia(SOD)" p. 278

  17. "Mutations within HESX1 have been described in association with both dominant and recessive forms of septo-optic dysplasia, combined pituitary hormone deficiency and isolated growth hormone deficiency" p. 207

  18. index cases with autosomal-dominant isolated growth hormone deficiency and normal GH-1 gene had no HESX-1 mutations

  19. Two novel HESX1 mutations in a so-far-undescribed disease phenotype characterized by a life-threatening neonatal condition associated with anterior pituitary aplasia, in the absence of ectopic posterior pituitary and optic nerve abnormalities.

  20. Mutations within HESX1 are a rare cause of septooptic dysplasia and hypopituitarism

Xenopus laevis HESX Homeobox 1 (HESX1) interaction partners

  1. Using specific regulatory elements from the Xanf1/Hesx1 promoter, study show that Xanf1/Hesx1-SoxD/Sox15-heterodimer can bind to these elements and stabilizes Xanf1/Hesx1 expression. This result explains how Xanf1/Hesx1 can escape inhibition by its own protein product and is consistent with the current model which proposes that Sox proteins regulate gene expression by forming complexes with other transcription factors.

  2. X-nkx-5.1 is stage-specific inhibitor of Xanf-1 in the anterior neural plate during the Xenopus development

  3. These results are consistent with a possible role of Zyxin as a negative modulator of Xanf1 transcriptional repressing activity.

  4. binding of the LIM2 domain of zyxin with the Engrailed Homology 1 repressor domain of Xanf1 is responsible for the interaction of these proteins.

HESX Homeobox 1 (HESX1) Antigen Profile

Protein Summary

This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency.

Gene names and symbols associated with anti-HESX Homeobox 1 (HESX1) Antibodies

  • homeobox gene expressed in ES cells (Hesx1) antibody
  • HESX homeobox 1 (Hesx1) antibody
  • HESX homeobox 1 (HESX1) antibody
  • HESX homeobox 1 L homeolog (hesx1.L) antibody
  • HESX homeobox 1 (hesx1) antibody
  • Anf antibody
  • anf1 antibody
  • anf2 antibody
  • CPHD5 antibody
  • danf antibody
  • GANF antibody
  • HES-1 antibody
  • HESX1 antibody
  • RGD1563858 antibody
  • rpx antibody
  • Xanf antibody
  • xanf-1 antibody
  • XANF-2 antibody
  • Xanf2 antibody
  • zanf antibody

Protein level used designations for anti-HESX Homeobox 1 (HESX1) Antibodies

anterior-restricted homeobox protein , homeo box gene expressed in ES cells , homeobox expressed in ES cells 1 , homeobox protein ANF , rathke pouch homeo box , Rathke pouch homeobox , hAnf , homeobox, ES cell expressed 1 , homeo box (expressed in ES cells) 1 , Homeobox protein ANF-1 , homeobox expressed in ES cells 1-B , xanf1 , anterior neural fold protein , homeobox protein ANF-1 , homeobox protein GANF , homeodomain-containing protein , anf1 , anterior neural folds homolog

GENE ID SPECIES
15209 Mus musculus
498575 Rattus norvegicus
8820 Homo sapiens
747229 Pan troglodytes
397950 Xenopus laevis
100967444 Pan paniscus
100008708 Oryctolagus cuniculus
395864 Gallus gallus
30620 Danio rerio
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