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HESX1 encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland.
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Hesx1 plays a significant role in sustaining pluripotency in embryonic stem cells.Hesx1 transcriptionally suppresses differentiation-related genes.
Wnt (show WNT2 Antibodies) inhibition during the first day has larger impact on the activation of Hesx1 and Six3, suggesting that in embryos Wnt (show WNT2 Antibodies) inhibition caused by Dkk1 (show DKK1 Antibodies) contributes greatly in the establishment of the anterior forebrain precursor.
Variability in Hes1 (show HES1 Antibodies) expression therefore helps to explain why STAT3 (show STAT3 Antibodies) responsiveness varies between individual ES cells, and this in turn helps to explain why pluripotent cells commit to differentiate asynchronously..
Transcriptional profiling of anterior forebrain precursors from mouse embryos expressing eGFP from the Hesx1 locus provides molecular evidence supporting a novel function of Hesx1 in mediating repression of Wnt (show WNT2 Antibodies)/beta-catenin (show CTNNB1 Antibodies) target activation.
Studies suggest that TLE1 (show TLE1 Antibodies) and TLE3 (show TLE3 Antibodies) might also play roles independent of HESX1 by interacting with other transcription factors like PROP1 (show PROP1 Antibodies).
Data suggest that formation of a heterodimer between HESX1 and PROP1 (show PROP1 Antibodies) allows HESX1 to become active, and that PROP1 (show PROP1 Antibodies) then replaces HESX1 to advance to the middle stage of pituitary development.
A novel inducible element, activated by contact with Rathke's pouch, is present in the regulatory region of the Hesx1 homeobox (show PRRX1 Antibodies) gene.
the domains of Hes-1 (show HES1 Antibodies) needed to block adipogenesis coincide with those necessary for transcriptional repression.
Conserved regulatory elements establish the dynamic expression of Rpx in early development.
The absence of Hesx1 leads to a posterior transformation of the anterior forebrain (AFB) during mouse development.
Study did not identify HESX1 and LHX3 (show LHX3 Antibodies) mutations by Sanger in brazilian patients with combined pituitary hormone (show CGA Antibodies) deficiency
HESX1 mutations cause variable clinical features in congenital hypopituitarism patients, which suggests an influence of modifier genes or environmental factors on the phenotype
A novel heterozygous mutation in the HESX1 gene and a novel homozygous mutation in the PROP1 (show PROP1 Antibodies) gene were detected in 2 pedigrees with combined pituitary hormone (show CGA Antibodies) deficiency
investigated the specific mutations in PROP1 (show PROP1 Antibodies), POU1F1 (show POU1F1 Antibodies), LHX3 (show LHX3 Antibodies), and HESX1 genes in patients with combined pituitary hormone (show CGA Antibodies) deficiency (CPHD) in Turkey
Data indicate that HESX1, LHX4 (show LHX4 Antibodies) and SOX3 (show SOX3 Antibodies) polymorphisms may be associated with pituitary stalk interruption syndrome (PSIS).
expand the phenotypic spectrum of HESX1 mutations in Kallman syndrome.
Data show no mutations in HESX1, PROP1 (show PROP1 Antibodies), and POU1F1 (show POU1F1 Antibodies) genes, seven different mutations in CTNNB1 (show CTNNB1 Antibodies) in 8/16 patients, and hyperexpression of miR (show MLXIP Antibodies)-150.
A c.357+3G>A mutation prevents the generation of one of the alternative isoforms normally produced by the wild-type allele, predicting a truncated HESX1 protein.
A novel HESX1 causative mutation was found in a consanguineous family, and two LHX4 (show LHX4 Antibodies) mutations were present in familial Pituitary stalk interruption syndrome.
Mutations in the PROP1 (show PROP1 Antibodies) and HESX1 genes were not identified in these patients with sporadic growth hormone (show GH1 Antibodies) defiency, combined pituitary hormone (show CGA Antibodies) deficiency and septo-optic dysplasia.
Using specific regulatory elements from the Xanf1/Hesx1 promoter, study show that Xanf1/Hesx1-SoxD/Sox15-heterodimer can bind to these elements and stabilizes Xanf1/Hesx1 expression. This result explains how Xanf1/Hesx1 can escape inhibition by its own protein product and is consistent with the current model which proposes that Sox proteins regulate gene expression by forming complexes with other transcription factors.
X-nkx-5.1 is stage-specific inhibitor of Xanf-1 in the anterior neural plate during the Xenopus development
These results are consistent with a possible role of Zyxin as a negative modulator of Xanf1 transcriptional repressing activity.
binding of the LIM2 domain of zyxin with the Engrailed Homology 1 repressor domain of Xanf1 is responsible for the interaction of these proteins.
This gene encodes a conserved homeobox protein that is a transcriptional repressor in the developing forebrain and pituitary gland. Mutations in this gene are associated with septooptic dysplasia, HESX1-related growth hormone deficiency, and combined pituitary hormone deficiency.
anterior-restricted homeobox protein
, homeo box gene expressed in ES cells
, homeobox expressed in ES cells 1
, homeobox protein ANF
, rathke pouch homeo box
, Rathke pouch homeobox
, homeobox, ES cell expressed 1
, homeo box (expressed in ES cells) 1
, Homeobox protein ANF-1
, homeobox expressed in ES cells 1-B
, anterior neural fold protein
, homeobox protein ANF-1
, homeobox protein GANF
, homeodomain-containing protein
, anterior neural folds homolog