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In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Additionally we are shipping Homeobox A3 Antibodies (75) and many more products for this protein.
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Study indicated that low HOXA3 expression may play a certain role in lung adenocarcinoma; however, its association with lung squamous cell carcinoma still requires further investigation.
this study indicated that HOXA3 might act as a promoter of human colon cancer formation by regulating EGFR/Ras/Raf/MEK/ERK signaling pathway. HOXA3 might be a potential therapeutic target for the treatment of colon cancer.
aim of this work was to search for mutations in thyroid developmental candidate genes HOXA3, HOXB3, HOXD3 and PITX2
HOXA7, HOXB3, HOXA3, and HOXB13 expression levels changed during angiogenesis, sugessting these proteins might be involved in the angiogenesis of hMSCs.
HoxA3 induced upregulation of Jag1 ligand in endothelial cells, which led to cis-inhibition of the Notch pathway, rendering the HE nonresponsive to Notch signals.
Our findings suggest a role for Hox a3 protein activity in promoting M1-to-M2-like phenotypic switching via interactions with myeloid transcription factors and provide insight into mechanisms regulating this process in diabetic wound healing
ultiple roles for HOXA3 in regulating thymus and parathyroid differentiation and morphogenesis in mouse.
Studies indicate that Hoxa3 promotes proliferation and differentiation of HSC/Ps into Gr-1+CD11b+ myeloid cells.
Data show that HoxA3 restrains haematopoietic differentiation of the earliest endothelial progenitors, and induces reversion of the earliest haematopoietic progenitors into CD41-negative endothelial cells.
demonstrate that zebrafish hoxa3a (zfhoxa3a) expressed from the mouse Hoxa3 locus can substitute for mouse Hoxa3 in some tissues, but has distinct or null phenotypes in others.
homeobox gene hoxa3 is essential for the formation of the carotid body in the mouse embryos
Hoxa3 gene is crucial for the formation of the common carotid artery and the null mutant mice are the first useful animal models to show that the third arch arteries on both sides specifically degenerate but the fourth and sixth arch arteries are normal
Results suggest that members of the Hox groups (Hoxa3, Hoxb3, Hoxd3) coordinate both suppression and activation mechanisms that ensure distinction between the multiple rhombomeres in the developing hindbrain.
The proximal 2-kb of the Hoxa3 promoter directs gene expression in distinct branchial compartments and cranial ganglia.
Hoxa3 regulates the proliferation and differentiation of the 3rd pharyngeal arch mesoderm.
HOXA3 can facilitate tissue remodeling via coordinated changes in both epithelial and endothelial cell gene expression and behavior in adult tissues during wound repair.
Dual origins of the carotid body revealed by targeted disruption of Hoxa3 and Mash1.
HOXA3 accelerates wound repair by mobilizing endothelial progenitor cells and attenuating the excessive inflammatory response of chronic wounds.
Oculomotor circuits in hindbrain rhombomeres 5-6 develop and function independently of hox3 genes.
In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. Three transcript variants encoding two different isoforms have been found for this gene.
, homeo box 1E
, homeo box A3
, homeobox protein Hox-1E
, homeobox protein Hox-A3
, homeobox A2
, homeobox protein Hox-1.5
, homeobox protein MO-10
, homeobox a3a
, homeobox protein Hox-A3a
, homeobox A3
, homeobox protein Hox-D3
, homeodomain protein HOXD-3
, similar to homeobox A3 isoform a
, homeobox A3, isoform 2
, homeobox protein Hox-A3-like
, Homeobox protein Hox-A3a
, homeobox protein HoxA3a