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Cytokine with immunomodulatory activity. Additionally we are shipping Interleukin 28A (Interferon, lambda 2) Antibodies (119) and Interleukin 28A (Interferon, lambda 2) Kits (41) and many more products for this protein.
Showing 10 out of 30 products:
Fetuses lacking IFN-lambda signaling had increased Zika virus replication in the placenta, and treatment of pregnant mice with IFN-lambda2 reduced ZIKV infection.
IFN-lambda2 and its receptor may become targets of anti-cancer therapy.
IL28 controls proliferation of IECs in mice with colitis and accelerates mucosal healing by activating STAT1 (show STAT1 Proteins).
IL-28A is capable of exacerbating a T-cell-mediated autoimmune disease.
Data indicate that rotavirus infection induces production of interferon (show IFNA Proteins)-lambda (IFN-lambda) and interleukin 22 (IL-22 (show IL22 Proteins)) by intestinal epithelial cells.
IL-28A exerts its antiinflammatory effect by restricting recruitment of IL-1b (show IL1B Proteins)-expressing neutrophils
The level of IFN-lambda2 was significantly increased in the infected cells treated with with shRNAs against influenza a virus M1.
IFN-lambda2 limits VSV replication in the mouse lung.
Data indicate that IPS-1 (show ISYNA1 Proteins)-dependent pathway plays a crucial role in type III IFN production by CD8 (show CD8A Proteins)(+) dendritic cells (DCs) and hepatocytes in response to hepatitis C virus (HCV), leading to cytoplasmic antiviral protein expressions.
NS of severe fever with thrombocytopenia syndrome virus inhibited the activity of IFN-alpha1 (show IFNA1 Proteins), IFN-beta (show IFNB1 Proteins), IFN-lambda1 and IFN-lambda2 through inhibition of STAT1 (show STAT1 Proteins) phosphorylation.
Studies indicate that the type III interferons (IFNs) or IFN-lambdas consists of four members: IFN-lambda1 (IL-29 (show IL29 Proteins)), IFN-lambda2 (IL28A), IFN-lambda3 (IL-28B (show IL28B Proteins)) and IFN-lambda4.
Results showed no association between genotypes and alleles of IL28A, IL28B (show IL28B Proteins) or IL29 (show IL29 Proteins) polymorphisms and Hepatitis C virus infection.
this study provides evidence for potential IL-28A participation in Behcet's diseaseand its value as a therapeutic agent.
Interferon (show IFNA Proteins) regulatory factor (IRF)-3 (show IRF3 Proteins) and -7 are the key transcriptional factors for the induction of IL-28A and IL-28B (show IL28B Proteins) genes, whereas NF-kappaB (show NFKB1 Proteins) is an additional requirement for the induction of the IL-29 (show IL29 Proteins) gene.
The results show that IL-28A/IL-28AR1 dyad-induced wound healing migration requires NF-kappaB (show NFKB1 Proteins)-mediated MMP-9 (show MMP9 Proteins) expression by MAPK (show MAPK1 Proteins) activation.
IL-28 genotype was not associated with response to interferon (show IFNA Proteins) treatment (OR for GT/GG vs. TT, 0.881 (95%CI 0.388 - 2.002); P = 0.762; OR for CT/CC vs. TT, 0.902 (95%CI 0.458 - 1.778); P = 0.766).
p38 MAPK (show MAPK14 Proteins) pathway mediates IL-28A-induced cell migration through MMP-9 (show MMP9 Proteins) expression by activating NF-kappaB (show NFKB1 Proteins) and AP-1 (show FOSB Proteins) binding motifs.
Elevated expression of inflammatory cytokines (IL-5 (show IL5 Proteins), IL-20 (show IL20 Proteins), and IL-28A) is associated with bladder cancer development.
Plasmacytoid dendritic cells are major producers of IFN-lambda2 (a type III interferon (show IFNA Proteins)) in response to viral stimulation.
Cytokine with immunomodulatory activity. Up-regulates MHC class I antigen expression. Displays potent antiviral activity. Also displays antitumor activity. Ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand/receptor complex seems to signal through the Jak-STAT pathway.
, interferon lambda-2
, interleukin 28A
, cytokine Zcyto20
, interferon lambda 2
, interferon-lambda 2
, interleukin 28A (interferon, lambda 2)