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Involved in the biogenesis of the 60S ribosomal subunit. Additionally we are shipping LAS1L Proteins (3) and and many more products for this protein.
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LAS1L interacts with PELP1 (show PELP1 Antibodies), TEX10, and WDR18 (show WDR18 Antibodies), the mammalian homologues of the budding yeast Rix1 complex, along with NOL9 (show NOL9 Antibodies) and SENP3 (show ULP1 Antibodies), to form a novel nucleolar complex that cofractionates with the 60S preribosomal subunit.
Analysis of high-molecular-weight RNAs confirmed that Las1L is required for ITS2 processing,which separates the 5.8S and 25S/28S rRNAs, as 32S was found to accumulate and 12S to diminish upon Las1L depletion.
Data demonstrate that Las1L is essential for cell proliferation and biogenesis of the 60S ribosomal subunit.
Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA (By similarity).
, protein LAS1 homolog
, ribosomal biogenesis protein LAS1L